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    Alg14 asparagine-linked glycosylation 14 [ Mus musculus (house mouse) ]

    Gene ID: 66789, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Alg14provided by MGI
    Official Full Name
    asparagine-linked glycosylation 14provided by MGI
    Primary source
    MGI:MGI:1914039
    See related
    Ensembl:ENSMUSG00000039887 AllianceGenome:MGI:1914039
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    5430428G01Rik
    Summary
    Predicted to enable protein-membrane adaptor activity. Predicted to be involved in dolichol-linked oligosaccharide biosynthetic process. Predicted to act upstream of with a positive effect on protein N-linked glycosylation. Predicted to be part of UDP-N-acetylglucosamine transferase complex. Predicted to be active in cytoplasmic side of endoplasmic reticulum membrane. Is expressed in several structures, including early conceptus; gallbladder; genitourinary system; gut gland; and nervous system. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 15. Orthologous to human ALG14 (ALG14 UDP-N-acetylglucosaminyltransferase subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 8.4), subcutaneous fat pad adult (RPKM 8.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Alg14 in Genome Data Viewer
    Location:
    3 G1; 3 52.94 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (121085361..121156745)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (121291712..121363096)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene TLC domain containing 4 Neighboring gene predicted gene, 52661 Neighboring gene within bgcn homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_08838 Neighboring gene STARR-positive B cell enhancer ABC_E4584 Neighboring gene STARR-positive B cell enhancer mm9_chr3:121010508-121010808 Neighboring gene STARR-positive B cell enhancer ABC_E11213 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:121047938-121048139 Neighboring gene predicted gene, 33310 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:121068079-121068270 Neighboring gene STARR-positive B cell enhancer mm9_chr3:121072387-121072688 Neighboring gene STARR-positive B cell enhancer mm9_chr3:121073107-121073408 Neighboring gene STARR-seq mESC enhancer starr_08839 Neighboring gene predicted gene, 33363 Neighboring gene STARR-seq mESC enhancer starr_08840 Neighboring gene peptidylprolyl isomerase A pseudogene 3_1234.1 Neighboring gene predicted gene, 40134

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each. Dogar AM, et al. PLoS One, 2018. PMID 30418981, Free PMC Article
    2. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein-membrane adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-membrane adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in dolichol-linked oligosaccharide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_positive_effect protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_positive_effect protein N-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of UDP-N-acetylglucosamine transferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of UDP-N-acetylglucosamine transferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of UDP-N-acetylglucosamine transferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytoplasmic side of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic side of endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    UDP-N-acetylglucosamine transferase subunit ALG14; UDP-N-acetylglucosamine transferase subunit ALG14 homolog
    Names
    asparagine-linked glycosylation 14 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024178.3 → NP_077140.1  UDP-N-acetylglucosamine transferase subunit ALG14

      See identical proteins and their annotated locations for NP_077140.1

      Status: VALIDATED

      Source sequence(s)
      AC105336, AC161210
      Consensus CDS
      CCDS17801.1
      UniProtKB/Swiss-Prot
      Q8CEP2, Q9D081
      Related
      ENSMUSP00000038387.8, ENSMUST00000039442.12
      Conserved Domains (1) summary
      pfam08660
      Location:39 → 216
      Alg14; Oligosaccharide biosynthesis protein Alg14 like

    RNA

    1. NR_155539.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC105336, AC161210

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      121085361..121156745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501899.3 → XP_006501962.1  UDP-N-acetylglucosamine transferase subunit ALG14 homolog isoform X1

      Conserved Domains (1) summary
      pfam08660
      Location:39 → 221
      Alg14; Oligosaccharide biosynthesis protein Alg14 like

    RNA

    1. XR_003954370.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D081.1 GenPept UniProtKB/Swiss-Prot:Q9D081

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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