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    Arrdc4 arrestin domain containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 66412, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Arrdc4provided by MGI
    Official Full Name
    arrestin domain containing 4provided by MGI
    Primary source
    MGI:MGI:1913662
    See related
    Ensembl:ENSMUSG00000042659 AllianceGenome:MGI:1913662
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410003C09Rik
    Summary
    Enables ubiquitin-like ligase-substrate adaptor activity. Involved in extracellular vesicle biogenesis; protein transport; and protein ubiquitination. Located in extracellular vesicle and plasma membrane. Orthologous to human ARRDC4 (arrestin domain containing 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 15.0), colon adult (RPKM 8.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arrdc4 in Genome Data Viewer
    Location:
    7 C; 7 37.81 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (68386742..68398986, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (68736994..68749238, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34549 Neighboring gene STARR-seq mESC enhancer starr_19116 Neighboring gene tetraspanin 7 pseudogene Neighboring gene STARR-seq mESC enhancer starr_19117 Neighboring gene STARR-seq mESC enhancer starr_19119 Neighboring gene STARR-seq mESC enhancer starr_19120 Neighboring gene STARR-seq mESC enhancer starr_19121 Neighboring gene predicted gene, 34612 Neighboring gene predicted gene, 34664 Neighboring gene STARR-seq mESC enhancer starr_19123

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An insulin-regulated arrestin domain protein controls hepatic glucagon action. Dagdeviren S, et al. J Biol Chem, 2023 Aug. PMID 37451484, Free PMC Article
    2. Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart. Nakayama Y, et al. Circ Res, 2022 Sep 2. PMID 35950500, Free PMC Article
    3. Arrdc4-dependent extracellular vesicle biogenesis is required for sperm maturation. Foot NJ, et al. J Extracell Vesicles, 2021 Jun. PMID 34188787, Free PMC Article
    4. Systemic Deletion of ARRDC4 Improves Cardiac Reserve and Exercise Capacity in Diabetes. Nakayama Y, et al. Circ Res, 2024 Jul 19. PMID 38946541,
    5. TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4. Wang H, et al. Cell Death Dis, 2021 Dec 17. PMID 34916487, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Systemic Deletion of ARRDC4 Improves Cardiac Reserve and Exercise Capacity in Diabetes.
      Title: Systemic Deletion of ARRDC4 Improves Cardiac Reserve and Exercise Capacity in Diabetes.
    2. Identification of HDAC9 and ARRDC4 as potential biomarkers and targets for treatment of type 2 diabetes.
      Title: Identification of HDAC9 and ARRDC4 as potential biomarkers and targets for treatment of type 2 diabetes.
    3. An insulin-regulated arrestin domain protein controls hepatic glucagon action.
      Title: An insulin-regulated arrestin domain protein controls hepatic glucagon action.
    4. Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart.
      Title: Interaction of ARRDC4 With GLUT1 Mediates Metabolic Stress in the Ischemic Heart.
    5. TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.
      Title: TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.
    6. Arrdc4-dependent extracellular vesicle biogenesis is required for sperm maturation.
      Title: Arrdc4-dependent extracellular vesicle biogenesis is required for sperm maturation.
    7. Txnip regulates cellular metabolism independent of its binding to thioredoxin and the arrestin domains are crucial structural elements in metabolic functions of alpha-arrestin proteins
      Title: Thioredoxin-independent regulation of metabolism by the alpha-arrestin proteins.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in extracellular vesicle biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of interferon-beta production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of interferon-beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    arrestin domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001042592.2 → NP_001036057.1  arrestin domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001036057.1

      Status: VALIDATED

      Source sequence(s)
      AK037198, AV245884, BY738896
      Consensus CDS
      CCDS39985.1
      UniProtKB/Swiss-Prot
      A0A0B4J1F4, Q8VD69
      UniProtKB/TrEMBL
      Q0GJK1
      Related
      ENSMUSP00000044578.8, ENSMUST00000048068.15
      Conserved Domains (2) summary
      smart01017
      Location:188 → 315
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:19 → 166
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    2. NM_025549.3 → NP_079825.2  arrestin domain-containing protein 4 isoform 2

      See identical proteins and their annotated locations for NP_079825.2

      Status: VALIDATED

      Source sequence(s)
      AK010352, AK037198, BY738896
      Consensus CDS
      CCDS52272.1
      UniProtKB/TrEMBL
      Q9D6S6
      Related
      ENSMUSP00000112962.2, ENSMUST00000118110.3
      Conserved Domains (2) summary
      smart01017
      Location:188 → 292
      Arrestin_C; Arrestin (or S-antigen), C-terminal domain
      pfam00339
      Location:23 → 166
      Arrestin_N; Arrestin (or S-antigen), N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      68386742..68398986 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4J1F4.1 GenPept UniProtKB/Swiss-Prot:A0A0B4J1F4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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