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    Vstm5 V-set and transmembrane domain containing 5 [ Mus musculus (house mouse) ]

    Gene ID: 69137, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Vstm5provided by MGI
    Official Full Name
    V-set and transmembrane domain containing 5provided by MGI
    Primary source
    MGI:MGI:1916387
    See related
    Ensembl:ENSMUSG00000031937 AllianceGenome:MGI:1916387
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2200002K05Rik
    Summary
    Involved in several processes, including filopodium assembly; positive regulation of excitatory synapse assembly; and protein homooligomerization. Located in axon; dendrite; and plasma membrane. Is expressed in central nervous system; dorsal root ganglion; gut; and urinary system. Orthologous to human VSTM5 (V-set and transmembrane domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in stomach adult (RPKM 16.5), large intestine adult (RPKM 15.2) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Vstm5 in Genome Data Viewer
    Location:
    9 A2; 9 4.72 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (15150197..15170717)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (15238901..15259421)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22658 Neighboring gene STARR-seq mESC enhancer starr_23369 Neighboring gene STARR-seq mESC enhancer starr_23370 Neighboring gene predicted gene, 39293 Neighboring gene predicted gene, 51702 Neighboring gene STARR-seq mESC enhancer starr_23372 Neighboring gene mediator complex subunit 17 Neighboring gene RIKEN cDNA 4931406C07 gene Neighboring gene STARR-positive B cell enhancer ABC_E6715 Neighboring gene TATA-box binding protein associated factor, RNA polymerase I, D

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. VSTM5 is a novel immune checkpoint that promotes oral tolerance of cell-mediated and antibody responses. Oludada OE, et al. Biochem Biophys Res Commun, 2022 Dec 20. PMID 36308908
    2. Differential effects of N-linked glycosylation of Vstm5 at multiple sites on surface expression and filopodia formation. Lee AR, et al. PLoS One, 2017. PMID 28746350, Free PMC Article
    3. T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells. Kim HR, et al. Nat Commun, 2018 Sep 7. PMID 30194420, Free PMC Article
    4. Putative Cell Adhesion Membrane Protein Vstm5 Regulates Neuronal Morphology and Migration in the Central Nervous System. Lee AR, et al. J Neurosci, 2016 Sep 28. PMID 27683913, Free PMC Article
    5. Cellular heterogeneity in the ureteric progenitor niche and distinct profiles of branching morphogenesis in organ development. Rutledge EA, et al. Development, 2017 Sep 1. PMID 28705898, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VSTM5 is a novel immune checkpoint that promotes oral tolerance of cell-mediated and antibody responses.
      Title: VSTM5 is a novel immune checkpoint that promotes oral tolerance of cell-mediated and antibody responses.
    2. Data indicate that four N-linked glycosylation sites (Asn43, Asn87, Asn101, and Asn108) are predicted to be located in the extracellular N-terminus of V-set and transmembrane domain-containing protein 5 (Vstm5), but their functional roles may not be identical.
      Title: Differential effects of N-linked glycosylation of Vstm5 at multiple sites on surface expression and filopodia formation.
    3. In this study, we demonstrate for the first time that V-set and transmembrane domain-containing protein 5 (Vstm5), a putative cell adhesion membrane protein, modulates both the position and complexity of central neurons by altering their membrane morphology and dynamics.
      Title: Putative Cell Adhesion Membrane Protein Vstm5 Regulates Neuronal Morphology and Migration in the Central Nervous System.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in filopodium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in filopodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of excitatory synapse assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of excitatory synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein homooligomerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ventral spinal cord development IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    V-set and transmembrane domain-containing protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026955.2 → NP_081231.1  V-set and transmembrane domain-containing protein 5 precursor

      See identical proteins and their annotated locations for NP_081231.1

      Status: PROVISIONAL

      Source sequence(s)
      AK034938
      Consensus CDS
      CCDS22833.1
      UniProtKB/Swiss-Prot
      Q9D806
      Related
      ENSMUSP00000034413.7, ENSMUST00000034413.8
      Conserved Domains (1) summary
      cl11960
      Location:43 → 137
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      15150197..15170717
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242595.3 → XP_011240897.1  V-set and transmembrane domain-containing protein 5 isoform X1

      Conserved Domains (1) summary
      cl11960
      Location:48 → 137
      Ig; Immunoglobulin domain

    2. XM_011242596.3 → XP_011240898.1  V-set and transmembrane domain-containing protein 5 isoform X2

      Conserved Domains (1) summary
      cl11960
      Location:48 → 137
      Ig; Immunoglobulin domain

    RNA

    1. XR_379133.4 RNA Sequence

    2. XR_870538.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D806.1 GenPept UniProtKB/Swiss-Prot:Q9D806

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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