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    Cap2 cyclase associated actin cytoskeleton regulatory protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 67252, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Cap2provided by MGI
    Official Full Name
    cyclase associated actin cytoskeleton regulatory protein 2provided by MGI
    Primary source
    MGI:MGI:1914502
    See related
    Ensembl:ENSMUSG00000021373 AllianceGenome:MGI:1914502
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810452G09Rik
    Summary
    Predicted to enable actin binding activity; adenylate cyclase binding activity; and identical protein binding activity. Involved in presynaptic actin cytoskeleton organization. Located in postsynaptic density. Is expressed in several structures, including head mesenchyme; heart; metanephros; telencephalon; and vertebral axis musculature. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CAP2 (cyclase associated actin cytoskeleton regulatory protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 35.6), bladder adult (RPKM 29.6) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cap2 in Genome Data Viewer
    Location:
    13 A5; 13 23.83 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (46655379..46803757)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (46501903..46650281)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_34408 Neighboring gene stathmin domain containing 1 Neighboring gene RNA binding motif protein 24 Neighboring gene STARR-seq mESC enhancer starr_34412 Neighboring gene predicted gene, 35110 Neighboring gene STARR-seq mESC enhancer starr_34413 Neighboring gene STARR-seq mESC enhancer starr_34414 Neighboring gene VISTA enhancer mm132 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:46712127-46712352 Neighboring gene STARR-seq mESC enhancer starr_34416 Neighboring gene family with sequence similarity 8, member A1 Neighboring gene STARR-seq mESC enhancer starr_34420 Neighboring gene nucleoporin 153 Neighboring gene STARR-positive B cell enhancer ABC_E9876 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:46831628-46831815 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:46831840-46832060 Neighboring gene predicted gene, 46412

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deficiency of cyclase-associated protein 2 promotes arrhythmias associated with connexin43 maldistribution and fibrosis. Stöckigt F, et al. Arch Med Sci, 2016 Feb 1. PMID 26925136, Free PMC Article
    2. Neuronal Actin Dynamics, Spine Density and Neuronal Dendritic Complexity Are Regulated by CAP2. Kumar A, et al. Front Cell Neurosci, 2016. PMID 27507934, Free PMC Article
    3. CAP2 is a regulator of actin pointed end dynamics and myofibrillogenesis in cardiac muscle. Colpan M, et al. Commun Biol, 2021 Mar 19. PMID 33742108, Free PMC Article
    4. CAP2 in cardiac conduction, sudden cardiac death and eye development. Field J, et al. Sci Rep, 2015 Nov 30. PMID 26616005, Free PMC Article
    5. CAP2 is a regulator of the actin cytoskeleton and its absence changes infiltration of inflammatory cells and contraction of wounds. Kosmas K, et al. Eur J Cell Biol, 2015 Jan. PMID 25464902

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cyclase-associated protein interacts with actin filament barbed ends to promote depolymerization and formin displacement.
      Title: Cyclase-associated protein interacts with actin filament barbed ends to promote depolymerization and formin displacement.
    2. Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts.
      Title: Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts.
    3. Functional Redundancy of Cyclase-Associated Proteins CAP1 and CAP2 in Differentiating Neurons.
      Title: Functional Redundancy of Cyclase-Associated Proteins CAP1 and CAP2 in Differentiating Neurons.
    4. CAP2 is a regulator of actin pointed end dynamics and myofibrillogenesis in cardiac muscle.
      Title: CAP2 is a regulator of actin pointed end dynamics and myofibrillogenesis in cardiac muscle.
    5. Investigated CAP adenylate cyclase-associated protein 2 (CAP2) functon in regulating the alpha-actin exchange during myofibril differentiation and skeletal muscle development.
      Title: CAP2 deficiency delays myofibril actin cytoskeleton differentiation and disturbs skeletal muscle architecture and function.
    6. These studies establish a direct role for CAP2 and actin dynamics in sudden cardiac death and cardiac conduction disease.
      Title: CAP2 in cardiac conduction, sudden cardiac death and eye development.
    7. Taken together, our studies reveal a role for CAP2 in wound healing which may be based on its function as a regulator of the actin cytoskeleton.
      Title: CAP2 is a regulator of the actin cytoskeleton and its absence changes infiltration of inflammatory cells and contraction of wounds.
    8. CAP2 is an essential component of the myocardial sarcomere and is essential for physiological functioning of the cardiac system, and a deficiency leads to DCM and various cardiac defects.
      Title: Ablation of cyclase-associated protein 2 (CAP2) leads to cardiomyopathy.
    9. CAP2 is significantly expressed only in brain, heart and skeletal muscle, and skin, a C-terminal fragment of CAP2 interacts with actin, indicating that CAP2 has the capacity to bind to actin
      Title: CAP2, cyclase-associated protein 2, is a dual compartment protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in presynaptic actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in presynaptic actin cytoskeleton organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in presynaptic actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of modification of postsynaptic actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in glutamatergic synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    adenylyl cyclase-associated protein 2
    Names
    CAP, adenylate cyclase-associated protein, 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026056.4 → NP_080332.1  adenylyl cyclase-associated protein 2

      See identical proteins and their annotated locations for NP_080332.1

      Status: VALIDATED

      Source sequence(s)
      AK013331, AK033071, AK035556, BM899250
      Consensus CDS
      CCDS26484.1
      UniProtKB/Swiss-Prot
      Q80YU7, Q9CYT6, Q9D6L0
      UniProtKB/TrEMBL
      A0A286YCS6
      Related
      ENSMUSP00000021802.9, ENSMUST00000021802.16
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 296
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:322 → 474
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      46655379..46803757
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006516946.3 → XP_006517009.1  adenylyl cyclase-associated protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A286YCS6
      Conserved Domains (2) summary
      pfam01213
      Location:35 → 326
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:352 → 504
      CAP_C; Adenylate cyclase associated (CAP) C terminal

    2. XM_030247379.1 → XP_030103239.1  adenylyl cyclase-associated protein 2 isoform X2

      UniProtKB/Swiss-Prot
      Q80YU7, Q9CYT6, Q9D6L0
      UniProtKB/TrEMBL
      A0A286YCS6
      Related
      ENSMUSP00000153125.2, ENSMUST00000225824.2
      Conserved Domains (2) summary
      pfam01213
      Location:5 → 296
      CAP_N; Adenylate cyclase associated (CAP) N terminal
      pfam08603
      Location:322 → 474
      CAP_C; Adenylate cyclase associated (CAP) C terminal
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CYT6.1 GenPept UniProtKB/Swiss-Prot:Q9CYT6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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