U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dynlt4 dynein light chain Tctex-type 4 [ Mus musculus (house mouse) ]

    Gene ID: 242646, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dynlt4provided by MGI
    Official Full Name
    dynein light chain Tctex-type 4provided by MGI
    Primary source
    MGI:MGI:3045358
    See related
    Ensembl:ENSMUSG00000047671 AllianceGenome:MGI:3045358
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tctex1d4; 4833401D15Rik
    Summary
    Predicted to enable dynein intermediate chain binding activity and protein phosphatase 1 binding activity. Predicted to be involved in microtubule-based movement. Located in acrosomal vesicle; cytoskeleton; and nucleus. Orthologous to human DYNLT4 (dynein light chain Tctex-type 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in ovary adult (RPKM 16.9), lung adult (RPKM 14.6) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Dynlt4 in Genome Data Viewer
    Location:
    4 D1; 4 53.41 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (116981734..116985935)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (117124543..117128738)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2B, subunit 3 Neighboring gene predicted gene, 22335 Neighboring gene STARR-seq mESC enhancer starr_11152 Neighboring gene Ptch2 Hedgehog-responsive enhancers Neighboring gene patched 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:116793139-116793326 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:116797070-116797223 Neighboring gene BTB domain containing 19 Neighboring gene STARR-positive B cell enhancer ABC_E2707 Neighboring gene STARR-positive B cell enhancer ABC_E7981 Neighboring gene polo like kinase 3 Neighboring gene bestrophin 4, pseudogene Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein phosphatase 1 binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in axoneme IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of cytoplasmic dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule organizing center IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule organizing center ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    dynein light chain Tctex-type 4
    Names
    Tctex1 domain containing 4
    tctex1 domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175030.2NP_778195.1  dynein light chain Tctex-type 4

      See identical proteins and their annotated locations for NP_778195.1

      Status: PROVISIONAL

      Source sequence(s)
      AK029345
      Consensus CDS
      CCDS18528.1
      UniProtKB/Swiss-Prot
      A2AE79, A2AE80, Q14C28, Q8CDY7
      UniProtKB/TrEMBL
      A0A0A0MQL6
      Related
      ENSMUSP00000052243.3, ENSMUST00000062206.3
      Conserved Domains (1) summary
      pfam03645
      Location:121217
      Tctex-1; Tctex-1 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      116981734..116985935
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503100.5XP_006503163.1  dynein light chain Tctex-type 4 isoform X1

      See identical proteins and their annotated locations for XP_006503163.1

      UniProtKB/Swiss-Prot
      A2AE79, A2AE80, Q14C28, Q8CDY7
      UniProtKB/TrEMBL
      A0A0A0MQL6
      Conserved Domains (1) summary
      pfam03645
      Location:121217
      Tctex-1; Tctex-1 family
    2. XM_006503098.5XP_006503161.1  dynein light chain Tctex-type 4 isoform X1

      See identical proteins and their annotated locations for XP_006503161.1

      UniProtKB/Swiss-Prot
      A2AE79, A2AE80, Q14C28, Q8CDY7
      UniProtKB/TrEMBL
      A0A0A0MQL6
      Conserved Domains (1) summary
      pfam03645
      Location:121217
      Tctex-1; Tctex-1 family
    3. XM_006503099.5XP_006503162.1  dynein light chain Tctex-type 4 isoform X1

      See identical proteins and their annotated locations for XP_006503162.1

      UniProtKB/Swiss-Prot
      A2AE79, A2AE80, Q14C28, Q8CDY7
      UniProtKB/TrEMBL
      A0A0A0MQL6
      Conserved Domains (1) summary
      pfam03645
      Location:121217
      Tctex-1; Tctex-1 family
    4. XM_006503097.5XP_006503160.1  dynein light chain Tctex-type 4 isoform X1

      See identical proteins and their annotated locations for XP_006503160.1

      UniProtKB/Swiss-Prot
      A2AE79, A2AE80, Q14C28, Q8CDY7
      UniProtKB/TrEMBL
      A0A0A0MQL6
      Related
      ENSMUSP00000122605.2, ENSMUST00000144269.2
      Conserved Domains (1) summary
      pfam03645
      Location:121217
      Tctex-1; Tctex-1 family