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    Tmem222 transmembrane protein 222 [ Mus musculus (house mouse) ]

    Gene ID: 52174, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem222provided by MGI
    Official Full Name
    transmembrane protein 222provided by MGI
    Primary source
    MGI:MGI:1098568
    See related
    Ensembl:ENSMUSG00000028857 AllianceGenome:MGI:1098568
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D4Ertd196e; 5730406H10Rik
    Summary
    Predicted to be located in dendrite. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and hemolymphoid system. Orthologous to human TMEM222 (transmembrane protein 222). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 33.8), cortex adult (RPKM 33.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem222 in Genome Data Viewer
    Location:
    4 D2.3; 4 66.25 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (132993356..133005101, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (133266045..133277791, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2126 Neighboring gene ficolin C pseudogene Neighboring gene mitogen-activated protein kinase kinase kinase 6 Neighboring gene synaptotagmin-like 1 Neighboring gene STARR-seq mESC enhancer starr_11620 Neighboring gene STARR-seq mESC enhancer starr_11622 Neighboring gene STARR-positive B cell enhancer mm9_chr4:132865900-132866201 Neighboring gene WD and tetratricopeptide repeats 1 Neighboring gene STARR-positive B cell enhancer ABC_E7995 Neighboring gene STARR-seq mESC enhancer starr_11626 Neighboring gene STARR-seq mESC enhancer starr_11627 Neighboring gene STARR-positive B cell enhancer ABC_E1657 Neighboring gene microRNA 5122 Neighboring gene solute carrier family 9 (sodium/hydrogen exchanger), member 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • DKFZp564D0478

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 222

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025667.3 → NP_079943.2  transmembrane protein 222

      See identical proteins and their annotated locations for NP_079943.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the supported protein.
      Source sequence(s)
      AI847863, AK079189, AK160188
      Consensus CDS
      CCDS51321.1
      UniProtKB/Swiss-Prot
      A2AE96, Q8BVA2, Q8CI41, Q9CYN3
      Related
      ENSMUSP00000101527.3, ENSMUST00000105907.9
      Conserved Domains (1) summary
      pfam05608
      Location:61 → 178
      DUF778; Protein of unknown function (DUF778)

    RNA

    1. NR_110978.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AI834770, AK079189, AK160188

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      132993356..133005101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006539036.3 → XP_006539099.1  transmembrane protein 222 isoform X1

      Conserved Domains (1) summary
      pfam05608
      Location:1 → 82
      DUF778; Protein of unknown function (DUF778)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BVA2.1 GenPept UniProtKB/Swiss-Prot:Q8BVA2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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