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    Mctp2 multiple C2 domains, transmembrane 2 [ Mus musculus (house mouse) ]

    Gene ID: 244049, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Mctp2provided by MGI
    Official Full Name
    multiple C2 domains, transmembrane 2provided by MGI
    Primary source
    MGI:MGI:2685335
    See related
    Ensembl:ENSMUSG00000032776 AllianceGenome:MGI:2685335
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm489
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in regulation of neurotransmitter secretion. Predicted to be located in cytosol; membrane; and nucleoplasm. Predicted to be active in synaptic vesicle membrane. Orthologous to human MCTP2 (multiple C2 and transmembrane domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in bladder adult (RPKM 1.2), colon adult (RPKM 0.7) and 20 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mctp2 in Genome Data Viewer
    Location:
    7 D1; 7 41.23 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (71727575..71956850, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (72077827..72307116, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930441H08 gene Neighboring gene RIKEN cDNA 1700011C11 gene Neighboring gene STARR-seq mESC enhancer starr_19150 Neighboring gene glycine cleavage system protein H (aminomethyl carrier) pseudogene Neighboring gene STARR-seq mESC enhancer starr_19151 Neighboring gene STARR-seq mESC enhancer starr_19152 Neighboring gene predicted gene, 36633 Neighboring gene STARR-seq mESC enhancer starr_19153 Neighboring gene STARR-seq mESC enhancer starr_19154 Neighboring gene predicted gene, 36696 Neighboring gene STARR-seq mESC enhancer starr_19156 Neighboring gene STARR-positive B cell enhancer ABC_E3727 Neighboring gene STARR-seq mESC enhancer starr_19157 Neighboring gene predicted gene, 39035 Neighboring gene STARR-seq mESC enhancer starr_19158 Neighboring gene STARR-seq mESC enhancer starr_19160 Neighboring gene ribosomal protein L17, pseudogene 10 Neighboring gene KAT8 regulatory NSL complex subunit 2, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Effect of expression alteration in flanking genes on phenotypes of St8sia2-deficient mice. Ikegami K, et al. Sci Rep, 2019 Sep 20. PMID 31541165, Free PMC Article
    2. A Role for Sensory end Organ-Derived Signals in Regulating Muscle Spindle Proprioceptor Phenotype. Wu D, et al. J Neurosci, 2019 May 29. PMID 30926747, Free PMC Article
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    NOT enables calcium-dependent phospholipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of neurotransmitter secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    multiple C2 and transmembrane domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024703.1 → NP_001019874.1  multiple C2 and transmembrane domain-containing protein 2

      See identical proteins and their annotated locations for NP_001019874.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086658
      Consensus CDS
      CCDS21361.1
      UniProtKB/Swiss-Prot
      Q5RJH2
      Related
      ENSMUSP00000078302.6, ENSMUST00000079323.8
      Conserved Domains (4) summary
      cd04042
      Location:195 → 314
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:357 → 469
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:509 → 627
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:771 → 824
      PRT_C; Plant phosphoribosyltransferase C-terminal

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      71727575..71956850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242581.2 → XP_030098441.1  multiple C2 and transmembrane domain-containing protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q5RJH2
      Conserved Domains (4) summary
      cd04042
      Location:195 → 314
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:357 → 469
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:509 → 627
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:771 → 824
      PRT_C; Plant phosphoribosyltransferase C-terminal

    2. XM_006540899.4 → XP_006540962.1  multiple C2 and transmembrane domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006540962.1

      UniProtKB/Swiss-Prot
      Q5RJH2
      Conserved Domains (4) summary
      cd04042
      Location:195 → 314
      C2A_MCTP_PRT; C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08376
      Location:357 → 469
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:509 → 627
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:771 → 824
      PRT_C; Plant phosphoribosyltransferase C-terminal

    3. XM_006540901.2 → XP_006540964.1  multiple C2 and transmembrane domain-containing protein 2 isoform X2

      Conserved Domains (4) summary
      cd08376
      Location:170 → 282
      C2B_MCTP_PRT; C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      cd08377
      Location:322 → 440
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:584 → 637
      PRT_C; Plant phosphoribosyltransferase C-terminal
      cl14603
      Location:24 → 127
      C2; C2 domain

    4. XM_011250864.1 → XP_011249166.1  multiple C2 and transmembrane domain-containing protein 2 isoform X3

      Conserved Domains (3) summary
      cd08377
      Location:97 → 215
      C2C_MCTP_PRT; C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)
      pfam08372
      Location:359 → 412
      PRT_C; Plant phosphoribosyltransferase C-terminal
      cl14603
      Location:1 → 57
      C2; C2 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5RJH2.1 GenPept UniProtKB/Swiss-Prot:Q5RJH2

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