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    YEH2 sterol esterase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850707, updated on 9-Dec-2024

    Summary

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    Official Symbol
    YEH2
    Official Full Name
    sterol esterase
    Primary source
    SGD:S000004010
    Locus tag
    YLR020C
    See related
    AllianceGenome:SGD:S000004010; FungiDB:YLR020C; VEuPathDB:YLR020C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables sterol ester esterase activity. Involved in cell wall mannoprotein biosynthetic process and sterol metabolic process. Located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See YEH2 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (181789..183405, complement)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene Pom34p Neighboring gene putative phosphatase Neighboring gene Irc25p Neighboring gene guanine nucleotide exchange factor SDO1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. YEH2/YLR020c encodes a novel steryl ester hydrolase of the yeast Saccharomyces cerevisiae. Müllner H, et al. J Biol Chem, 2005 Apr 8. PMID 15632184
    2. Derivatization-independent cholesterol analysis in crude lipid extracts by liquid chromatography/mass spectrometry: applications to a rabbit model for atherosclerosis. Shui G, et al. J Chromatogr A, 2011 Jul 15. PMID 21621788
    3. Characterization of sterol-ester hydrolase in Saccharomyces cerevisiae. Taketani S, et al. Biochim Biophys Acta, 1978 Jul 7. PMID 28772
    4. The Saccharomyces cerevisiae YLL012/YEH1, YLR020/YEH2, and TGL1 genes encode a novel family of membrane-anchored lipases that are required for steryl ester hydrolysis. Köffel R, et al. Mol Cell Biol, 2005 Mar. PMID 15713625, Free PMC Article
    5. Mobilization of steryl esters from lipid particles of the yeast Saccharomyces cerevisiae. Wagner A, et al. Biochim Biophys Acta, 2009 Feb. PMID 19111628

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that the gene product of YEH2/ YLR020c is a steryl ester hydrolase.
      Title: YEH2/YLR020c encodes a novel steryl ester hydrolase of the yeast Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol ester esterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sterol ester esterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sterol ester esterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol ester esterase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell wall mannoprotein biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sterol metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sterol esterase
    NP_013120.1
    • Steryl ester hydrolase; catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism; YEH2 has a paralog, YEH1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      181789..183405 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181907.1 → NP_013120.1  TPA: sterol esterase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013120.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY22, Q07950
      UniProtKB/TrEMBL
      A7A0S5, B3LSZ3, C7GXG6, C8ZCZ2, G2WIL4, N1P0E0
      Conserved Domains (2) summary
      PLN02872
      Location:163 → 298
      PLN02872; triacylglycerol lipase
      cl21494
      Location:194 → 435
      Abhydrolase; alpha/beta hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07950.1

    Gene LinkOut

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