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    DANCR differentiation antagonizing non-protein coding RNA [ Homo sapiens (human) ]

    Gene ID: 57291, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DANCRprovided by HGNC
    Official Full Name
    differentiation antagonizing non-protein coding RNAprovided by HGNC
    Primary source
    HGNC:HGNC:28964
    See related
    Ensembl:ENSG00000226950 MIM:614625; AllianceGenome:HGNC:28964
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AGU2; ANCR; SNHG13; KIAA0114; lncRNA-ANCR
    Summary
    This gene produces a long non-coding RNA that functions as a negative regulator of cell differentiation. This transcript associates with enhancer of zeste homolog 2 to repress expression of the runt related transcription factor 2 gene. Increased expression of this transcript may be associated with cancer. Alternatively spliced transcript variants have been observed. [provided by RefSeq, Dec 2016]
    Expression
    Ubiquitous expression in ovary (RPKM 52.8), thyroid (RPKM 36.9) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DANCR in Genome Data Viewer
    Location:
    4q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (52712394..52720697)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (56199289..56207592)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (53578561..53586864)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 46 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:53505773-53506003 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21555 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15424 Neighboring gene USP46 divergent transcript Neighboring gene ReSE screen-validated silencer GRCh37_chr4:53578367-53579200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21556 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21557 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15427 Neighboring gene microRNA 4449 Neighboring gene small nucleolar RNA, H/ACA box 26 Neighboring gene endogenous retrovirus group MER34 member 1, envelope Neighboring gene small nucleolar RNA SNORA26 Neighboring gene uncharacterized LOC107986281

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA DANCR promotes ATG7 expression to accelerate hepatocellular carcinoma cell proliferation and autophagy by sponging miR-222-3p. Wang X, et al. Eur Rev Med Pharmacol Sci, 2020 Sep. PMID 32964966
    2. lncRNA DANCR suppresses odontoblast-like differentiation of human dental pulp cells by inhibiting wnt/β-catenin pathway. Chen L, et al. Cell Tissue Res, 2016 May. PMID 26646542
    3. Long non-coding DANCR targets miR-185-5p to upregulate LIM and SH3 protein 1 promoting prostate cancer via the FAK/PI3K/AKT/GSK3β/snail pathway. Sun W, et al. J Gene Med, 2021 Jul. PMID 33885171
    4. Antidifferentiation Noncoding RNA Regulates the Proliferation of Osteosarcoma Cells. Min L, et al. Cancer Biother Radiopharm, 2016 Mar. PMID 26986815
    5. Emerging role of lncRNA DANCR in progenitor cells: beyond cancer. Zhang Z, et al. Eur Rev Med Pharmacol Sci, 2021 Feb. PMID 33629310

    See all (121) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HOXB2 promotes cisplatin resistance by upregulating lncRNA DANCR in ovarian cancer.
      Title: HOXB2 promotes cisplatin resistance by upregulating lncRNA DANCR in ovarian cancer.
    2. Depression of LncRNA DANCR alleviates tubular injury in diabetic nephropathy by regulating KLF5 through sponge miR-214-5p.
      Title: Depression of LncRNA DANCR alleviates tubular injury in diabetic nephropathy by regulating KLF5 through sponge miR-214-5p.
    3. Long non-coding RNA DANCR aggravates breast cancer through the miR-34c/E2F1 feedback loop.
      Title: Long non‑coding RNA DANCR aggravates breast cancer through the miR‑34c/E2F1 feedback loop.
    4. Exploring the effect of LncRNA DANCR to regulate the Keap1-Nrf2/ARE pathway on oxidative stress in rheumatoid arthritis.
      Title: Exploring the effect of LncRNA DANCR to regulate the Keap1-Nrf2/ARE pathway on oxidative stress in rheumatoid arthritis.
    5. IGF2BP2 promotes lncRNA DANCR stability mediated glycolysis and affects the progression of FLT3-ITD + acute myeloid leukemia.
      Title: IGF2BP2 promotes lncRNA DANCR stability mediated glycolysis and affects the progression of FLT3-ITD + acute myeloid leukemia.
    6. LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway.
      Title: LncRNA DANCR deficiency promotes high glucose-induced endothelial to mesenchymal transition in cardiac microvascular cells via the FoxO1/DDAH1/ADMA signaling pathway.
    7. Decreased DANCR contributes to high glucose-induced extracellular matrix accumulation in human renal mesangial cell via regulating the TGF-beta/Smad signaling.
      Title: Decreased DANCR contributes to high glucose-induced extracellular matrix accumulation in human renal mesangial cell via regulating the TGF-β/Smad signaling.
    8. DANCR Induces Cisplatin Resistance of Triple-Negative Breast Cancer by KLF5/p27 Signaling.
      Title: DANCR Induces Cisplatin Resistance of Triple-Negative Breast Cancer by KLF5/p27 Signaling.
    9. LncRNA DANCR counteracts premature ovarian insufficiency by regulating the senescence process of granulosa cells through stabilizing the interaction between p53 and hNRNPC.
      Title: LncRNA DANCR counteracts premature ovarian insufficiency by regulating the senescence process of granulosa cells through stabilizing the interaction between p53 and hNRNPC.
    10. DANCR promotes glioma cell autophagy and proliferation via the miR33b/DLX6/ATG7 axis.
      Title: DANCR promotes glioma cell autophagy and proliferation via the miR‑33b/DLX6/ATG7 axis.
    Submit: New GeneRIF Correction See all GeneRIFs (102)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Other Names

    • adipogenesis up-regulated transcript 2
    • anti-differentiation ncRNA
    • anti-differentiation noncoding RNA
    • small nucleolar RNA host gene 13 (non-protein coding)

    Clone Names

    • KIAA0114, KIAA00167

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_024031.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript.
      Source sequence(s)
      AC104066, D28589, LC128578
      Related
      ENST00000411630.7

    2. NR_145129.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' exon structure and is longer than variant 1.
      Source sequence(s)
      AC104066, LC128578

    3. NR_145130.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' exon structure and is longer than variant 1.
      Source sequence(s)
      AC104066, LC128577
      Related
      ENST00000675705.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      52712394..52720697
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      56199289..56207592
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Chemical Information
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    Research Materials