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    Ccl27al C-C motif chemokine ligand 27A like [ Mus musculus (house mouse) ]

    Gene ID: 100039863, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ccl27alprovided by MGI
    Official Full Name
    C-C motif chemokine ligand 27A likeprovided by MGI
    Primary source
    MGI:MGI:3713752
    See related
    Ensembl:ENSMUSG00000073877 AllianceGenome:MGI:3713752
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm2506; Gm13306; 100039939
    Summary
    Predicted to enable CCR3 chemokine receptor binding activity. Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide and killing of cells of another organism. Is expressed in hip; sensory organ; and skeleton. Orthologous to human CCL27 (C-C motif chemokine ligand 27). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 30.8), testis adult (RPKM 20.9) and 15 other tissues See more
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    Genomic context

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    See Ccl27al in Genome Data Viewer
    Location:
    4 A5; 4 22.29 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (42153404..42158846)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (42153404..42158846)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene C-C motif chemokine ligand 21F Neighboring gene C-C motif chemokine ligand 19, pseudogene 3 Neighboring gene interleukin 11 receptor subunit alpha 3 Neighboring gene predicted gene, 53181 Neighboring gene C-C motif chemokine ligand 21B (leucine) Neighboring gene STARR-seq mESC enhancer starr_10038 Neighboring gene STARR-seq mESC enhancer starr_10039 Neighboring gene STARR-seq mESC enhancer starr_10040 Neighboring gene family with sequence similarity 205 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. CCL27 is a crucial regulator of immune homeostasis of the skin and mucosal tissues. Davila ML, et al. iScience, 2022 Jun 17. PMID 35663027, Free PMC Article
    2. Isolation of ALP, a novel divergent murine CC chemokine with a unique carboxy terminal extension. Hromas R, et al. Biochem Biophys Res Commun, 1999 May 19. PMID 10329455
    3. Molecular cloning of a novel CC chemokine, interleukin-11 receptor alpha-locus chemokine (ILC), which is located on chromosome 9p13 and a potential homologue of a CC chemokine encoded by molluscum contagiosum virus. Ishikawa-Mochizuki I, et al. FEBS Lett, 1999 Nov 5. PMID 10556532
    4. ESkine, a novel beta-chemokine, is differentially spliced to produce secretable and nuclear targeted isoforms. Baird JW, et al. J Biol Chem, 1999 Nov 19. PMID 10559234
    5. CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells. Morales J, et al. Proc Natl Acad Sci U S A, 1999 Dec 7. PMID 10588729, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC41145

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables CCR3 chemokine receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in killing of cells of another organism ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    chemokine (C-C motif) ligand 27b

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164046.1 → NP_001157518.1  chemokine (C-C motif) ligand 27b isoform 2 precursor

      See identical proteins and their annotated locations for NP_001157518.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) has a distinct and shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK005520, BY613083, BY652838
      Consensus CDS
      CCDS51149.1
      UniProtKB/Swiss-Prot
      Q3KNL1, Q9DAU6, Q9DAZ4, Q9Z1X0
      UniProtKB/TrEMBL
      A2AMS5
      Related
      ENSMUSP00000095726.3, ENSMUST00000098122.3
      Conserved Domains (1) summary
      cl00134
      Location:34 → 83
      Chemokine; Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...

    2. NM_001199962.1 → NP_001186891.1  chemokine (C-C motif) ligand 27b isoform 1

      See identical proteins and their annotated locations for NP_001186891.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL824709, BY279294
      Consensus CDS
      CCDS57270.1
      UniProtKB/Swiss-Prot
      Q9Z1X0
      Related
      ENSMUSP00000103653.3, ENSMUST00000108018.9
      Conserved Domains (1) summary
      cl00134
      Location:49 → 98
      Chemokine; Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided ...

    3. NM_001199963.1 → NP_001186892.1  chemokine (C-C motif) ligand 27b isoform 3

      See identical proteins and their annotated locations for NP_001186892.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The encoded isoform (3) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AL824709, BM119446
      Conserved Domains (1) summary
      pfam00048
      Location:39 → 99
      IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

    4. NM_001384256.1 → NP_001371185.1  chemokine (C-C motif) ligand 27b isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL824709
      Conserved Domains (1) summary
      pfam00048
      Location:72 → 132
      IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

    5. NM_001384257.1 → NP_001371186.1  chemokine (C-C motif) ligand 27b isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL824709
      Conserved Domains (1) summary
      pfam00048
      Location:92 → 152
      IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

    6. NM_001384258.1 → NP_001371187.1  chemokine (C-C motif) ligand 27b isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL824709
      Conserved Domains (1) summary
      pfam00048
      Location:39 → 99
      IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      42153404..42158846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163516.1 → XP_036019409.1  chemokine (C-C motif) ligand 27b isoform X1

      Conserved Domains (1) summary
      pfam00048
      Location:94 → 154
      IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

    2. XM_036163517.1 → XP_036019410.1  chemokine (C-C motif) ligand 27b isoform X2

      Conserved Domains (1) summary
      pfam00048
      Location:74 → 134
      IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

    3. XM_036163518.1 → XP_036019411.1  chemokine (C-C motif) ligand 27b isoform X3

      Conserved Domains (1) summary
      pfam00048
      Location:39 → 99
      IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

    4. XM_036163519.1 → XP_036019412.1  chemokine (C-C motif) ligand 27b isoform X3

      Conserved Domains (1) summary
      pfam00048
      Location:39 → 99
      IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

    5. XM_006537497.2 → XP_006537560.1  chemokine (C-C motif) ligand 27b isoform X3

      See identical proteins and their annotated locations for XP_006537560.1

      Conserved Domains (1) summary
      pfam00048
      Location:39 → 99
      IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

    6. XM_017319875.3 → XP_017175364.1  chemokine (C-C motif) ligand 27b isoform X3

      Conserved Domains (1) summary
      pfam00048
      Location:39 → 99
      IL8; Small cytokines (intecrine/chemokine), interleukin-8 like

    RNA

    1. XR_004941786.1 RNA Sequence

    2. XR_004941787.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001199964.1: Suppressed sequence

      Description
      NM_001199964.1: This RefSeq was permanently suppressed because this transcript variant is unsupported for this gene copy at the annotated genomic location on NCBI's Build 38.1.
    Nucleotide Protein Strain
    Heading Accession and Version

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