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    Tmem164 transmembrane protein 164 [ Mus musculus (house mouse) ]

    Gene ID: 209497, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem164provided by MGI
    Official Full Name
    transmembrane protein 164provided by MGI
    Primary source
    MGI:MGI:2148020
    See related
    Ensembl:ENSMUSG00000047045 AllianceGenome:MGI:2148020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    F730011B02
    Summary
    Predicted to be involved in positive regulation of ferroptosis. Predicted to be located in membrane. Orthologous to human TMEM164 (transmembrane protein 164). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 14.6), ovary adult (RPKM 13.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem164 in Genome Data Viewer
    Location:
    X F2; X 63.54 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (141463343..141626490)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (142680347..142843494)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene 15032 Neighboring gene regulator of G-protein signaling 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_48023 Neighboring gene STARR-seq mESC enhancer starr_48024 Neighboring gene microRNA 652 Neighboring gene POU domain, class 5, transcription factor 1, related sequence 13 Neighboring gene STARR-seq mESC enhancer starr_48025 Neighboring gene AMMECR nuclear protein 1 Neighboring gene STARR-seq mESC enhancer starr_48026 Neighboring gene retrotransposon Gag like 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice. Zhang L, et al. Nat Metab, 2023 Oct. PMID 37679556
    2. TMEM164 is a new determinant of autophagy-dependent ferroptosis. Liu J, et al. Autophagy, 2023 Mar. PMID 35947500, Free PMC Article
    3. TMEM164 promotes ferroptosis by selectively mediating ATG5-dependent autophagosome formation to inhibit the progression of LUAD. Su Y, et al. Autoimmunity, 2024 Dec. PMID 39392409
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TMEM164 promotes ferroptosis by selectively mediating ATG5-dependent autophagosome formation to inhibit the progression of LUAD.
      Title: TMEM164 promotes ferroptosis by selectively mediating ATG5-dependent autophagosome formation to inhibit the progression of LUAD.
    2. Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice.
      Title: Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice.
    3. TMEM164 is a new determinant of autophagy-dependent ferroptosis.
      Title: TMEM164 is a new determinant of autophagy-dependent ferroptosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in positive regulation of ferroptosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of ferroptosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of ferroptosis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 164
    Names
    arachidonoyl ether phospholipid synthase

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001199357.1 → NP_001186286.1  transmembrane protein 164 isoform b

      See identical proteins and their annotated locations for NP_001186286.1

      Status: VALIDATED

      Source sequence(s)
      AK166488, AL731674, AL731678
      Consensus CDS
      CCDS57778.1
      UniProtKB/TrEMBL
      A2AH99
      Related
      ENSMUSP00000108510.2, ENSMUST00000112889.8
      Conserved Domains (1) summary
      pfam14808
      Location:1 → 124
      TMEM164; TMEM164 family

    2. NM_001199360.1 → NP_001186289.1  transmembrane protein 164 isoform a

      See identical proteins and their annotated locations for NP_001186289.1

      Status: VALIDATED

      Source sequence(s)
      AL731674, AL731678, BF457004, CB525724
      Consensus CDS
      CCDS30451.1
      UniProtKB/Swiss-Prot
      Q6PHN7
      UniProtKB/TrEMBL
      Q8C237
      Related
      ENSMUSP00000108517.3, ENSMUST00000112896.9
      Conserved Domains (1) summary
      pfam14808
      Location:10 → 272
      TMEM164; TMEM164 family

    3. NM_001358725.1 → NP_001345654.1  transmembrane protein 164 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL731674, AL731678, BC059043
      Consensus CDS
      CCDS57778.1
      UniProtKB/TrEMBL
      A2AH99
      Conserved Domains (1) summary
      pfam14808
      Location:1 → 124
      TMEM164; TMEM164 family

    4. NM_001358727.1 → NP_001345656.1  transmembrane protein 164 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL731674, AL731678, BC059043, CB525911
      Consensus CDS
      CCDS57778.1
      UniProtKB/TrEMBL
      A2AH99
      Conserved Domains (1) summary
      pfam14808
      Location:1 → 124
      TMEM164; TMEM164 family

    5. NM_001358728.1 → NP_001345657.1  transmembrane protein 164 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL731674, AL731678, BC059043, BU703507
      Consensus CDS
      CCDS57778.1
      UniProtKB/TrEMBL
      A2AH99
      Related
      ENSMUSP00000098759.3, ENSMUST00000101198.9
      Conserved Domains (1) summary
      pfam14808
      Location:1 → 124
      TMEM164; TMEM164 family

    6. NM_177592.4 → NP_808260.2  transmembrane protein 164 isoform a

      See identical proteins and their annotated locations for NP_808260.2

      Status: VALIDATED

      Source sequence(s)
      AL731678, BC056470, BC059043
      Consensus CDS
      CCDS30451.1
      UniProtKB/Swiss-Prot
      Q6PHN7
      UniProtKB/TrEMBL
      Q8C237
      Related
      ENSMUSP00000084591.3, ENSMUST00000087333.9
      Conserved Domains (1) summary
      pfam14808
      Location:10 → 272
      TMEM164; TMEM164 family

    RNA

    1. NR_152447.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL731674, AL731678

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      141463343..141626490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006528784.4 → XP_006528847.1  transmembrane protein 164 isoform X6

      See identical proteins and their annotated locations for XP_006528847.1

      UniProtKB/TrEMBL
      A2AH99
      Conserved Domains (1) summary
      pfam14808
      Location:1 → 124
      TMEM164; TMEM164 family

    2. XM_030251291.2 → XP_030107151.1  transmembrane protein 164 isoform X1

      Conserved Domains (1) summary
      pfam14808
      Location:10 → 233
      TMEM164; TMEM164 family

    3. XM_006528781.3 → XP_006528844.1  transmembrane protein 164 isoform X3

      Conserved Domains (1) summary
      pfam14808
      Location:10 → 168
      TMEM164; TMEM164 family

    4. XM_030251292.2 → XP_030107152.1  transmembrane protein 164 isoform X5

      Conserved Domains (1) summary
      pfam14808
      Location:2 → 127
      TMEM164; TMEM164 family

    5. XM_006528780.3 → XP_006528843.1  transmembrane protein 164 isoform X2

      Conserved Domains (1) summary
      pfam14808
      Location:10 → 229
      TMEM164; TMEM164 family

    6. XM_006528779.3 → XP_006528842.1  transmembrane protein 164 isoform X1

      See identical proteins and their annotated locations for XP_006528842.1

      Conserved Domains (1) summary
      pfam14808
      Location:10 → 233
      TMEM164; TMEM164 family

    7. XM_011247804.3 → XP_011246106.1  transmembrane protein 164 isoform X4

      Conserved Domains (1) summary
      pfam14808
      Location:23 → 166
      TMEM164; TMEM164 family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PHN7.1 GenPept UniProtKB/Swiss-Prot:Q6PHN7

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