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    Tmed1 transmembrane p24 trafficking protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 17083, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmed1provided by MGI
    Official Full Name
    transmembrane p24 trafficking protein 1provided by MGI
    Primary source
    MGI:MGI:106201
    See related
    Ensembl:ENSMUSG00000032180 AllianceGenome:MGI:106201
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    St2l; Ly84l; Il1rl1l
    Summary
    Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to be located in endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; and plasma membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human TMED1 (transmembrane p24 trafficking protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 31.6), limb E14.5 (RPKM 24.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmed1 in Genome Data Viewer
    Location:
    9 A3; 9 7.81 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (21418676..21421530, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (21507380..21510234, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene dynamin 2 Neighboring gene predicted gene, 46104 Neighboring gene predicted gene, 57796 Neighboring gene microRNA 199a-1 Neighboring gene STARR-positive B cell enhancer ABC_E8279 Neighboring gene cDNA sequence AB124611 Neighboring gene STARR-positive B cell enhancer ABC_E11402 Neighboring gene STARR-positive B cell enhancer mm9_chr9:21350851-21351152 Neighboring gene coactivator-associated arginine methyltransferase 1 Neighboring gene STARR-seq mESC enhancer starr_23505 Neighboring gene predicted gene, 39303

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning of a putative ligand for the T1/ST2 receptor. Gayle MA, et al. J Biol Chem, 1996 Mar 8. PMID 8621446
    2. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    3. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in Golgi organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane emp24 domain-containing protein 1
    Names
    interleukin 1 receptor-like 1 ligand
    lymphocyte antigen 84 ligand
    p24 family protein gamma-1
    p24gamma1
    putative T1/ST2 receptor-binding protein
    transmembrane emp24 domain containing 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001324510.1 → NP_001311439.1  transmembrane emp24 domain-containing protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region, compared to variant 1. These differences cause translation initiation at a downstream start codon and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AK133513, CB203970
      UniProtKB/Swiss-Prot
      Q3V009

    2. NM_010744.4 → NP_034874.2  transmembrane emp24 domain-containing protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_034874.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK133513, BC138498
      Consensus CDS
      CCDS22904.1
      UniProtKB/Swiss-Prot
      Q3TUX8, Q3V009, Q61073, Q91YK3
      UniProtKB/TrEMBL
      B2RRM5
      Related
      ENSMUSP00000034698.8, ENSMUST00000034698.9
      Conserved Domains (1) summary
      pfam01105
      Location:33 → 219
      EMP24_GP25L; emp24/gp25L/p24 family/GOLD

    RNA

    1. NR_136911.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK133513, AK160525, BC138498
      Related
      ENSMUST00000214285.2

    2. NR_136912.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AA087804, AK133513, BC138498
      Related
      ENSMUST00000213316.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      21418676..21421530 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3V009.1 GenPept UniProtKB/Swiss-Prot:Q3V009

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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