Slc13a2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc13a2provided by MGI
Official Full Name: solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2provided by MGI
Primary source: MGI:MGI:1276558
See related: Ensembl:ENSMUSG00000001095 AllianceGenome:MGI:1276558
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nadc1; Nadc-1; mNaDC-1
Summary: Enables sodium:dicarboxylate symporter activity and succinate transmembrane transporter activity. Involved in succinate transmembrane transport. Predicted to be located in apical plasma membrane. Predicted to be active in plasma membrane. Is expressed in 4-cell stage embryo; nervous system; and sensory organ. Orthologous to human SLC13A2 (solute carrier family 13 member 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in colon adult (RPKM 77.1), large intestine adult (RPKM 68.5) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 46.74 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (78288102..78313107, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (78397276..78422281, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NaDC1 expression increased only in the proximal convoluted tubules and proximal straight tubules in knockout mice blocked both the citrate and NaDC1 changes
Title: Regulation of renal NaDC1 expression and citrate excretion by NBCe1-A.
Slc26a6-null mice exhibit increased renal and intestinal sodium-dependent succinate uptake, as well as urinary hyperoxaluria and hypocitraturia, but no change in urinary pH, indicating enhanced transport activity of NaDC-1.
Title: SLC26A6 and NaDC-1 transporters interact to regulate oxalate and citrate homeostasis.
The acid-activated pathway mediating stimulation of kidney NaDC-1 activity requires a functional ET(B) receptor in vivo and in vitro.
Title: Acid regulation of NaDC-1 requires a functional endothelin B receptor.
Sodium dicarboxylate cotransporter is involved in regulating levels of various Krebs cycle intermediates in the kidney, although impaired uptake of these intermediates does not significantly affect renal function under normal or ischemic stress.
Title: Generation and characterization of sodium-dicarboxylate cotransporter-deficient mice.
Substrate-dependent inward currents, measured using two-electrode voltage clamp, were similar for glutarate & succinate in Xenopus oocytes expressing mouse NaDC1. Currents evoked by glutarate in rabbit NaDC1 were about 5% of succinate-dependent currents.
Title: Transmembrane helices 3 and 4 are involved in substrate recognition by the Na+/dicarboxylate cotransporter, NaDC1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (2) 1 citation

General gene information

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Markers

D11Bhm54 (e-PCR), detects polymorphism
- UniSTS:141658

D11Seg22 (e-PCR), detects polymorphism
- UniSTS:141796

D11Seg25 (e-PCR), detects polymorphism
- UniSTS:141799

D11Seg26 (e-PCR), detects polymorphism
- UniSTS:141800

Slc13a2 (e-PCR), detects polymorphism
- UniSTS:547311

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables alpha-ketoglutarate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-ketoglutarate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables alpha-ketoglutarate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables fumarate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables fumarate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables fumarate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables sodium:dicarboxylate symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:dicarboxylate symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium:dicarboxylate symporter activity	ISO Inferred from Sequence Orthology more info
enables succinate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables succinate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in alpha-ketoglutarate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in alpha-ketoglutarate transport	ISO Inferred from Sequence Orthology more info
involved_in alpha-ketoglutarate transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to lithium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lithium ion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lithium ion	ISO Inferred from Sequence Orthology more info
involved_in fumarate transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in fumarate transport	ISO Inferred from Sequence Orthology more info
involved_in fumarate transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in succinate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in succinate transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in succinate transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: solute carrier family 13 member 2

Names: Na(+)/dicarboxylate cotransporter 1; renal sodium/dicarboxylate cotransporter; sodium/dicarboxylate co-transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022411.4 → NP_071856.1 solute carrier family 13 member 2

See identical proteins and their annotated locations for NP_071856.1

Status: VALIDATED

Source sequence(s)

AL591131

Consensus CDS

CCDS25103.1

UniProtKB/Swiss-Prot

Q9ES88

Related

ENSMUSP00000001122.6, ENSMUST00000001122.6

Conserved Domains (2) summary

TIGR00785
Location:43 → 553

dass; anion transporter

cl21473
Location:6 → 560

ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

78288102..78313107 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006532648.4 → XP_006532711.1 solute carrier family 13 member 2 isoform X3

Conserved Domains (1) summary

cl21473
Location:28 → 290

ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...
XM_006532645.4 → XP_006532708.1 solute carrier family 13 member 2 isoform X1

Conserved Domains (1) summary

cl21473
Location:6 → 380

ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...
XM_006532647.4 → XP_006532710.1 solute carrier family 13 member 2 isoform X2

Conserved Domains (1) summary

cl21473
Location:6 → 292

ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...
XM_006532649.4 → XP_006532712.1 solute carrier family 13 member 2 isoform X4

Conserved Domains (1) summary

cl21473
Location:6 → 289

ArsB_NhaD_permease; Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices ...