Dear dual endothelin 1, angiotensin II receptor [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Dearprovided by RGD
Full Name: dual endothelin 1, angiotensin II receptorprovided by RGD
Primary source: RGD:1303105
See related: EnsemblRapid:ENSRNOG00000033147 AllianceGenome:RGD:1303105
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: DEspR; Fbxw7-as1
Summary: Enables angiotensin type II receptor activity and endothelin receptor activity. Involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

Location:: 2q34

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (172594990..172598242, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (170296930..170300182, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (184243976..184247228)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables angiotensin type II receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables endothelin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables endothelin receptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables vascular endothelial growth factor binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiotensin-activated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in endothelin receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in vascular endothelial growth factor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: dual endothelin-1/VEGF signal peptide receptor

Names: FBXW7 antisense RNA 1 homolog; dual endothelin-1/VEGFsp receptor; dual endothelin-1/angiotensin-2 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.