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    ND-MNLL NADH dehydrogenase (ubiquinone) MNLL subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31697, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ND-MNLLprovided by FlyBase
    Official Full Name
    NADH dehydrogenase (ubiquinone) MNLL subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0029971
    Locus tag
    Dmel_CG18624
    See related
    AllianceGenome:FB:FBgn0029971
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15328; CG18624; Dmel\CG18624; dNDUFB1; Dromel_CG18624_FBtr0071140_mORF; NDUFB1; NINM
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Part of respiratory chain complex I. Is expressed in adult head. Orthologous to human NDUFB1 (NADH:ubiquinone oxidoreductase subunit B1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See ND-MNLL in Genome Data Viewer
    Location:
    7C2-7C2; 1-21 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (7893053..7893798, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (7787086..7787831, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Acetyl-CoA acetyltransferase 1 Neighboring gene Nek2 Neighboring gene uncharacterized protein Neighboring gene p115 Neighboring gene pseudo

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CGG repeat expansion in NOTCH2NLC causes mitochondrial dysfunction and progressive neurodegeneration in Drosophila model. Yu J, et al. Proc Natl Acad Sci U S A, 2022 Oct 11. PMID 36191230, Free PMC Article
    2. TRAP1 rescues PINK1 loss-of-function phenotypes. Zhang L, et al. Hum Mol Genet, 2013 Jul 15. PMID 23525905, Free PMC Article
    3. The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants. Vilain S, et al. PLoS Genet, 2012 Jan. PMID 22242018, Free PMC Article
    4. The membrane domain of respiratory complex I accumulates during muscle aging in Drosophila melanogaster. Hossain KFB, et al. Sci Rep, 2022 Dec 27. PMID 36575244, Free PMC Article
    5. Mitochondrial diseases: Drosophila melanogaster as a model to evaluate potential therapeutics. Foriel S, et al. Int J Biochem Cell Biol, 2015 Jun. PMID 25666557

    See all (46) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial electron transport, NADH to ubiquinone IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of respiratory chain complex I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of respiratory chain complex I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of respiratory chain complex I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    NADH dehydrogenase (ubiquinone) MNLL subunit
    Names
    CG18624-PA
    CG18624-PB
    CG18624-PC
    CG18624-PD
    CG18624-PE
    NADH ubiquinone oxidoreductase MNLL
    NADH-ubiquinone oxidoreductase MNLL subunit
    NADH:ubiquinone oxidoreductase MNLL subunit
    ND-MNLL-PA
    ND-MNLL-PB
    ND-MNLL-PC
    ND-MNLL-PD
    ND-MNLL-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      7893053..7893798 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169222.2 → NP_001162693.1  NADH dehydrogenase (ubiquinone) MNLL subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162693.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E797, Q9W3N7
      Conserved Domains (1) summary
      pfam08040
      Location:17 → 56
      NADH_oxidored; MNLL subunit

    2. NM_132188.3 → NP_572416.1  NADH dehydrogenase (ubiquinone) MNLL subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572416.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E797, Q9W3N7
      Related
      FBpp0071092
      Conserved Domains (1) summary
      pfam08040
      Location:17 → 56
      NADH_oxidored; MNLL subunit

    3. NM_001298059.1 → NP_001284988.1  NADH dehydrogenase (ubiquinone) MNLL subunit, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001284988.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E797, Q9W3N7
      Conserved Domains (1) summary
      pfam08040
      Location:17 → 56
      NADH_oxidored; MNLL subunit

    4. NM_001169223.2 → NP_001162694.1  NADH dehydrogenase (ubiquinone) MNLL subunit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162694.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E797, Q9W3N7
      Conserved Domains (1) summary
      pfam08040
      Location:17 → 56
      NADH_oxidored; MNLL subunit

    5. NM_167134.2 → NP_727209.1  NADH dehydrogenase (ubiquinone) MNLL subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727209.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8E797, Q9W3N7
      Related
      FBpp0071093
      Conserved Domains (1) summary
      pfam08040
      Location:17 → 56
      NADH_oxidored; MNLL subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3N7 Q9W3N7

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