Cyp6g1 Cytochrome P450 6g1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cyp6g1provided by FlyBase
Official Full Name: Cytochrome P450 6g1provided by FlyBase
Primary source: FLYBASE:FBgn0025454
Locus tag: Dmel_CG8453
See related: AllianceGenome:FB:FBgn0025454
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 6g1; anon-WO03025223.16; anon-WO03025223.17; CG8453; Cyp6-like; cyp6g1; Cyp6G1; CYP6g1; CYP6G1; Cyp6gl; DDT-R; Dmel-Cyp6g1; Dmel\CG8453; RDDT; RI; RI[DDT]; RI[II]; Rst(2)DDT
Summary: Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Involved in several processes, including insecticide catabolic process; response to DDT; and response to mercury ion. Is expressed in adult head; adult heart; embryonic/larval Malpighian tubule; embryonic/larval fat body; and embryonic/larval midgut. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 48E7-48E7; 2-66 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (12185667..12188431)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (8073172..8075936)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CYP6g1 role in the azinphos-methyl resistance
Title: Genomic and Transcriptomic Associations Identify a New Insecticide Resistance Phenotype for the Selective Sweep at the Cyp6g1 Locus of Drosophila melanogaster.
a combination of gene duplication, regulatory changes and protein coding changes has taken place at the Cyp6g1 locus during evolution and this locus may play a role in providing resistance to different environmental toxins in different Drosophila species
Title: Evolutionary changes in gene expression, coding sequence and copy-number at the Cyp6g1 locus contribute to resistance to multiple insecticides in Drosophila.
We find that Imidacloprid does not induce expression of the analyzed Cyp6g1 and Cyp6a2 genes.
Title: Imidacloprid does not induce Cyp genes involved in insecticide resistance of a mutant Drosophila melanogaster line.
Recombinant D. melanogaster CYP6G1 exhibited p-nitroanisole O-dealkylation activity but was not active against eleven other typical P450 marker substrates.
Title: Soluble and membrane-bound Drosophila melanogaster CYP6G1 expressed in Escherichia coli: purification, activity, and binding properties toward multiple pesticides.
expression and tolerance to methylmercury during development
Title: Drosophila CYP6g1 and its human homolog CYP3A4 confer tolerance to methylmercury during development.
Resistance to nicotine or related plant allelochemicals is one of the beneficial phenotypes conferred by the Accord insertion allele of CYP6G1.
Title: Accord insertion in the 5' flanking region of CYP6G1 confers nicotine resistance in Drosophila melanogaster.
The induction response of the P450 gene Cyp6g1 to the xenobiotic phenobarbital requires the presence of both tissue specific enhancers and a distinct cis-regulatory element.
Title: Induction of a detoxification gene in Drosophila melanogaster requires an interaction between tissue specific enhancers and a novel cis-regulatory element.
The active site of Cyp6g1 can accommodate differently shaped substrates.
Title: Homology modelling of Drosophila cytochrome P450 enzymes associated with insecticide resistance.
Cyp6g1 locus is a major contributor to Dichloro-Diphenyl-Trichloroethane resistance in field populations
Title: Copy number variation and transposable elements feature in recent, ongoing adaptation at the Cyp6g1 locus.
Caffeine, DDT and phenobarbital fail to induce upstream DNAs of Cyp6g1.
Title: Functional analysis of the cis-acting elements responsible for the induction of the Cyp6a8 and Cyp6g1 genes of Drosophila melanogaster by DDT, phenobarbital and caffeine.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in insecticide catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in insecticide catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to DDT	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to DDT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to insecticide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to mercury ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to organophosphorus	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: cytochrome P450 6g1

Names: CG8453-PA; CG8453-PB; CYP6-like; Cyp6g1-PA; Cyp6g1-PB; cytochrome P450; resistance to DDT; resistance to Insecticide-DDT; resistance to insecticide on chromosome 2

NP_001286335.1