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    Fam171b family with sequence similarity 171, member B [ Mus musculus (house mouse) ]

    Gene ID: 241520, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fam171bprovided by MGI
    Official Full Name
    family with sequence similarity 171, member Bprovided by MGI
    Primary source
    MGI:MGI:2444579
    See related
    Ensembl:ENSMUSG00000048388 AllianceGenome:MGI:2444579
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D430039N05Rik
    Summary
    Is active in synapse. Is expressed in central nervous system; dorsal root ganglion; sensory organ; and trigeminal nerve. Orthologous to human FAM171B (family with sequence similarity 171 member B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 51.1), cortex adult (RPKM 29.7) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Fam171b in Genome Data Viewer
    Location:
    2 D; 2 49.33 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (83642889..83713878)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (83812563..83883534)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7831 Neighboring gene STARR-positive B cell enhancer mm9_chr2:83505584-83505885 Neighboring gene zinc finger CCCH-type containing 15 Neighboring gene STARR-seq mESC enhancer starr_04989 Neighboring gene DNA methyltransferase 3-like, pseudogene 1 Neighboring gene integrin alpha V Neighboring gene STARR-positive B cell enhancer ABC_E2039 Neighboring gene STARR-positive B cell enhancer ABC_E7832 Neighboring gene zinc finger SWIM-type containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E11143 Neighboring gene CWC22 spliceosome-associated protein, retrotransposed 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Action potential-coupled Rho GTPase signaling drives presynaptic plasticity. O'Neil SD, et al. Elife, 2021 Jul 16. PMID 34269176, Free PMC Article
    2. Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13.3 microdeletion syndrome. Unda BK, et al. Mol Psychiatry, 2023 Apr. PMID 36604605, Free PMC Article
    3. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein FAM171B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175514.3 → NP_780723.1  protein FAM171B precursor

      See identical proteins and their annotated locations for NP_780723.1

      Status: VALIDATED

      Source sequence(s)
      AL772256, AL772301
      Consensus CDS
      CCDS16182.1
      UniProtKB/Swiss-Prot
      Q14CH0, Q8C756, Q8CAF3, Q8CBZ4, Q8CFT5
      Related
      ENSMUSP00000062702.4, ENSMUST00000051454.4
      Conserved Domains (1) summary
      pfam10577
      Location:82 → 821
      UPF0560; uncharacterized protein family UPF0560

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      83642889..83713878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161886.1 → XP_036017779.1  protein FAM171B isoform X2

      UniProtKB/Swiss-Prot
      Q14CH0, Q8C756, Q8CAF3, Q8CBZ4, Q8CFT5
      Conserved Domains (1) summary
      pfam10577
      Location:82 → 681
      UPF0560; Uncharacterized protein family UPF0560

    2. XM_006499465.3 → XP_006499528.1  protein FAM171B isoform X1

      UniProtKB/Swiss-Prot
      Q14CH0, Q8C756, Q8CAF3, Q8CBZ4, Q8CFT5
      Conserved Domains (1) summary
      pfam10577
      Location:6 → 745
      UPF0560; Uncharacterized protein family UPF0560
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q14CH0.2 GenPept UniProtKB/Swiss-Prot:Q14CH0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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