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    Slco6d1 solute carrier organic anion transporter family, member 6d1 [ Mus musculus (house mouse) ]

    Gene ID: 70866, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Slco6d1provided by MGI
    Official Full Name
    solute carrier organic anion transporter family, member 6d1provided by MGI
    Primary source
    MGI:MGI:1918116
    See related
    Ensembl:ENSMUSG00000026336 AllianceGenome:MGI:1918116
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4921511I05Rik
    Summary
    Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to be active in basolateral plasma membrane. Orthologous to human SLCO6A1 (solute carrier organic anion transporter family member 6A1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward testis adult (RPKM 6.0) See more
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    Genomic context

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    See Slco6d1 in Genome Data Viewer
    Location:
    1 D; 1 47.76 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (98348812..98444710)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (98421087..98516985)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene, 46078 Neighboring gene STARR-seq mESC enhancer starr_01790 Neighboring gene serine/threonine kinase 38 like pseudogene Neighboring gene predicted gene 7967 Neighboring gene STARR-seq mESC enhancer starr_01793 Neighboring gene STARR-seq mESC enhancer starr_01794 Neighboring gene STARR-seq mESC enhancer starr_01795 Neighboring gene predicted gene, 23434

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Homology

    Clone Names

    • MGC132957, MGC132958

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables sodium-independent organic anion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in sodium-independent organic anion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    solute carrier organic anion transporter family, member 6d1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164233.1 → NP_001157705.1  solute carrier organic anion transporter family, member 6d1 isoform 2

      See identical proteins and their annotated locations for NP_001157705.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, compared to variant 1. The resulting isoform (2) has a shorter C-terminus, compared to isoform 1.
      Source sequence(s)
      AK014872, BC112423, BY714392
      Consensus CDS
      CCDS48333.1
      UniProtKB/TrEMBL
      Q14DL2
      Related
      ENSMUSP00000123850.2, ENSMUST00000160796.2
      Conserved Domains (3) summary
      cd06174
      Location:87 → 463
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      cd01330
      Location:476 → 529
      KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
      pfam03137
      Location:86 → 643
      OATP; Organic Anion Transporter Polypeptide (OATP) family

    2. NM_027584.1 → NP_081860.1  solute carrier organic anion transporter family, member 6d1 isoform 1

      See identical proteins and their annotated locations for NP_081860.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK014872
      Consensus CDS
      CCDS48332.1
      UniProtKB/TrEMBL
      Q9D5W6
      Related
      ENSMUSP00000027575.7, ENSMUST00000027575.13
      Conserved Domains (1) summary
      cl28910
      Location:83 → 583
      MFS; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      98348812..98444710
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011248080.2 → XP_011246382.1  solute carrier organic anion transporter family, member 6d1 isoform X2

      See identical proteins and their annotated locations for XP_011246382.1

      Conserved Domains (1) summary
      cl28910
      Location:83 → 622
      MFS; Major Facilitator Superfamily

    2. XM_017312300.1 → XP_017167789.1  solute carrier organic anion transporter family, member 6d1 isoform X6

      UniProtKB/TrEMBL
      Q9D5W6
      Conserved Domains (1) summary
      cl28910
      Location:83 → 583
      MFS; Major Facilitator Superfamily

    3. XM_011248078.3 → XP_011246380.1  solute carrier organic anion transporter family, member 6d1 isoform X1

      Conserved Domains (1) summary
      cl28910
      Location:83 → 622
      MFS; Major Facilitator Superfamily

    4. XM_017312295.2 → XP_017167784.1  solute carrier organic anion transporter family, member 6d1 isoform X4

      Conserved Domains (1) summary
      cl28910
      Location:83 → 583
      MFS; Major Facilitator Superfamily

    5. XM_017312299.2 → XP_017167788.1  solute carrier organic anion transporter family, member 6d1 isoform X5

      Conserved Domains (1) summary
      cl28910
      Location:84 → 579
      MFS; Major Facilitator Superfamily

    6. XM_017312293.2 → XP_017167782.1  solute carrier organic anion transporter family, member 6d1 isoform X3

      Conserved Domains (1) summary
      cl28910
      Location:68 → 592
      MFS; Major Facilitator Superfamily

    7. XM_017312301.2 → XP_017167790.1  solute carrier organic anion transporter family, member 6d1 isoform X7

      Conserved Domains (1) summary
      cl28910
      Location:42 → 268
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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