TRPV4 transient receptor potential cation channel subfamily V member 4 [Gallus gallus (chicken)] - Gene

Summary

Symbol: TRPV4provided by CGNC
Full Name: transient receptor potential cation channel subfamily V member 4provided by CGNC
Primary source: CGNC:3836
See related: Ensembl:ENSGALG00010020674
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: VR-OAC
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 15

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	15	NC_052546.1 (6854331..6861491, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	15	NC_052587.1 (6864791..6871968, complement)

Chromosome 15 - NC_052546.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Backbone NMR assignments of the extensive human and chicken TRPV4 N-terminal intrinsically disordered regions as important players in ion channel regulation.
Title: Backbone NMR assignments of the extensive human and chicken TRPV4 N-terminal intrinsically disordered regions as important players in ion channel regulation.
TRPV4 ankyrin domain is a lipid-binding domain in which interactions with PI(4,5)P2.
Title: TRPV4 channel activity is modulated by direct interaction of the ankyrin domain to PI(4,5)P₂.
A multiligand binding site for ATP and calmodulin previously identified in the TRPV1 ankyrin repeat domain is conserved in TRPV3 and TRPV4, but not TRPV2.
Title: Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain.
PACSIN 3 specifically affects the endocytosis of TRPV4, thereby modulating its subcellular localization
Title: PACSINs bind to the TRPV4 cation channel. PACSIN 3 modulates the subcellular localization of TRPV4.

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General gene information

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Markers

Trpv4 (e-PCR), detects polymorphism
- UniSTS:531257

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium channel activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	IEA Inferred from Electronic Annotation more info	PubMed
involved_in calcium ion import across plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
involved_in osmosensory signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cilium	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: transient receptor potential cation channel subfamily V member 4

Names: vanilloid receptor-related osmotically activated channel protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204692.2 → NP_990023.2 transient receptor potential cation channel subfamily V member 4

Status: VALIDATED

Source sequence(s)

JAENSK010000260

UniProtKB/Swiss-Prot

A0A1D5PXA5, Q9DFS3

UniProtKB/TrEMBL

A0A8V0Z8C7

Related

ENSGALP00010029497.1, ENSGALT00010049942.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052546.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

6854331..6861491 complement

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GenBank, FASTA, Sequence Viewer (Graphics)