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    DLEU2 deleted in lymphocytic leukemia 2 [ Homo sapiens (human) ]

    Gene ID: 8847, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DLEU2provided by HGNC
    Official Full Name
    deleted in lymphocytic leukemia 2provided by HGNC
    Primary source
    HGNC:HGNC:13748
    See related
    Ensembl:ENSG00000231607 MIM:605766; AllianceGenome:HGNC:13748
    Gene type
    ncRNA
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ALT1; DLB2; LEU2; RFP2; BCMSUN; RFP2OS; MIR15AHG; TRIM13OS; LINC00022; NCRNA00022
    Summary
    This locus represents a microRNA host gene and also produces long alternatively spliced non-coding RNAs. This genome region was observed to be deleted or epigenetically suppressed in leukemia, and was implicated as a negative regulator of cell proliferation. However, an alternative transcript produced at this locus was also found to promote progression through the cell cycle via angiotensin I converting enzyme 2 and cyclin D1. [provided by RefSeq, Dec 2017]
    Expression
    Ubiquitous expression in bone marrow (RPKM 1.5), testis (RPKM 1.3) and 25 other tissues See more
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    Genomic context

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    See DLEU2 in Genome Data Viewer
    Location:
    13q14.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (49982549..50125541, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (49203159..49346123, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (50556685..50699677, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7755 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5349 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7756 Neighboring gene RNY4 pseudogene 9 Neighboring gene SPRY domain containing 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:50546741-50546933 Neighboring gene Sharpr-MPRA regulatory region 13323 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7757 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7758 Neighboring gene microRNA 3613 Neighboring gene tripartite motif containing 13 Neighboring gene potassium channel regulator Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5353 Neighboring gene Sharpr-MPRA regulatory region 84 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7759 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:50656434-50657229 Neighboring gene microRNA 16-1 Neighboring gene microRNA 15a Neighboring gene NANOG hESC enhancer GRCh37_chr13:50695956-50696481 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5354 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5355 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:50699798-50700508 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5358 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5359 Neighboring gene ribosomal protein L18 pseudogene 10 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:50715020-50715693 Neighboring gene deleted in lymphocytic leukemia 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7760 Neighboring gene uncharacterized LOC124900337 Neighboring gene ST13, Hsp70 interacting protein pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. LncRNA DLEU2 is activated by STAT1 and induces gastric cancer development via targeting miR-23b-3p/NOTCH2 axis and Notch signaling pathway. Li G, et al. Life Sci, 2021 Jul 15. PMID 33785336
    2. Role of Circular RNA DLEU2 in Human Acute Myeloid Leukemia. Wu DM, et al. Mol Cell Biol, 2018 Oct 15. PMID 30037980, Free PMC Article
    3. Therapeutic implications of activation of the host gene (Dleu2) promoter for miR-15a/16-1 in chronic lymphocytic leukemia. Kasar S, et al. Oncogene, 2014 Jun 19. PMID 23995789, Free PMC Article
    4. Upregulated long-non-coding RNA DLEU2 exon 9 expression was an independent indicator of unfavorable overall survival in patients with esophageal adenocarcinoma. Ma W, et al. Biomed Pharmacother, 2019 May. PMID 30849637
    5. DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1. Lerner M, et al. Exp Cell Res, 2009 Oct 15. PMID 19591824

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DLEU2/EZH2/GFI1 Axis Regulates the Proliferation and Apoptosis of Human Bone Marrow Mesenchymal Stem Cells.
      Title: DLEU2/EZH2/GFI1 Axis Regulates the Proliferation and Apoptosis of Human Bone Marrow Mesenchymal Stem Cells.
    2. LncRNA DLEU2 contributes to Taxol resistance of gastric cancer cells through regulating the miR-30c-5p-LDHA axis.
      Title: LncRNA DLEU2 contributes to Taxol resistance of gastric cancer cells through regulating the miR-30c-5p-LDHA axis.
    3. Deleted in lymphocytic leukemia 2 (DLEU2): a possible biomarker that holds promise for future diagnosis and treatment of cancer.
      Title: Deleted in lymphocytic leukemia 2 (DLEU2): a possible biomarker that holds promise for future diagnosis and treatment of cancer.
    4. Long noncoding RNA DLEU2 regulates the progression of Wilm's tumor via miR-539-3p/HOXB2 axis.
      Title: Long noncoding RNA DLEU2 regulates the progression of Wilm's tumor via miR-539-3p/HOXB2 axis.
    5. lncRNA DLEU2 Accelerates Oral Cancer Progression via miR-30a-5p/RAP1B Axis to Regulate p38 MAPK Signaling Pathway.
      Title: lncRNA DLEU2 Accelerates Oral Cancer Progression via miR-30a-5p/RAP1B Axis to Regulate p38 MAPK Signaling Pathway.
    6. LncRNA DLEU2 silencing impedes the migration, invasion and EMT in gastric cancer cell by suppressing PI3K/AKT signaling pathway.
      Title: LncRNA DLEU2 silencing impedes the migration, invasion and EMT in gastric cancer cell by suppressing PI3K/AKT signaling pathway.
    7. DLEU2 modulates proliferation, migration and invasion of platelet-derived growth factor-BB (PDGF-BB)-induced vascular smooth muscle cells (VSMCs) via miR-212-5p/YWHAZ axis.
      Title: DLEU2 modulates proliferation, migration and invasion of platelet-derived growth factor-BB (PDGF-BB)-induced vascular smooth muscle cells (VSMCs) via miR-212-5p/YWHAZ axis.
    8. Deleted in lymphocytic leukemia 2 induces retinoic acid receptor beta promoter methylation and mitogen activated kinase-like protein activation to enhance viability and mobility of colorectal cancer cells.
      Title: Deleted in lymphocytic leukemia 2 induces retinoic acid receptor beta promoter methylation and mitogen activated kinase-like protein activation to enhance viability and mobility of colorectal cancer cells.
    9. LINC00022 acts as an oncogene in colorectal cancer progression via sponging miR-375-3p to regulate FOXF1 expression.
      Title: LINC00022 acts as an oncogene in colorectal cancer progression via sponging miR-375-3p to regulate FOXF1 expression.
    10. E2F transcription factor 2-activated DLEU2 contributes to prostate tumorigenesis by upregulating serum and glucocorticoid-induced protein kinase 1.
      Title: E2F transcription factor 2-activated DLEU2 contributes to prostate tumorigenesis by upregulating serum and glucocorticoid-induced protein kinase 1.
    Submit: New GeneRIF Correction See all GeneRIFs (31)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Other Names

    • deleted in lymphocytic leukemia 2 (non-protein coding)
    • leukemia associated gene 2
    • long intergenic non-protein coding RNA 22
    • mir-15a-16-1 cluster host gene (non-protein coding)
    • ret finger protein 2 opposite strand

    Clone Names

    • MGC88287

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_152566.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AF529010, AY455757
      Related
      ENST00000621282.4

    2. NR_152567.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL137060
      Related
      ENST00000458725.9

    3. NR_152568.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL137060
      Related
      ENST00000433070.9

    4. NR_152569.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      BC038090, BG611461
      Related
      ENST00000421758.7

    5. NR_152570.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL137060
      Related
      ENST00000449579.3

    6. NR_152571.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL137060

    7. NR_152572.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL137060

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      49982549..50125541 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      49203159..49346123 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_006021.1: Suppressed sequence

      Description
      NM_006021.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.

    2. NR_002612.1: Suppressed sequence

      Description
      NR_002612.1: This RefSeq was removed because currently there is not sufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version

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