U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Nucleotide

    • Showing Current items.

    Ndfip2 Nedd4 family interacting protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 76273, updated on 27-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Ndfip2provided by MGI
    Official Full Name
    Nedd4 family interacting protein 2provided by MGI
    Primary source
    MGI:MGI:1923523
    See related
    Ensembl:ENSMUSG00000053253 AllianceGenome:MGI:1923523
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    N4wbp5a; mKIAA1165; 0710001O20Rik; 2810436B12Rik; 9130207N19Rik
    Summary
    Predicted to enable WW domain binding activity. Predicted to be involved in several processes, including negative regulation of transport; positive regulation of protein ubiquitination; and ubiquitin-dependent protein catabolic process. Predicted to be located in membrane and mitochondrion. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; gut; lower urinary tract; sensory organ; and submandibular gland primordium. Orthologous to human NDFIP2 (Nedd4 family interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in small intestine adult (RPKM 18.5), colon adult (RPKM 18.3) and 28 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Ndfip2 in Genome Data Viewer
    Location:
    14 E2.3; 14 55.64 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (105495975..105546732)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (105258591..105309298)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_37531 Neighboring gene plastin 3 (T-isoform) pseudogene Neighboring gene STARR-seq mESC enhancer starr_37532 Neighboring gene STARR-positive B cell enhancer ABC_E7349 Neighboring gene predicted gene, 22290 Neighboring gene STARR-positive B cell enhancer ABC_E11580 Neighboring gene predicted gene, 24207 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene STARR-seq mESC enhancer starr_37533 Neighboring gene RIKEN cDNA 5430440P10 gene Neighboring gene STARR-seq mESC enhancer starr_37534 Neighboring gene VISTA enhancer mm1111 Neighboring gene RIKEN cDNA 4930449E01 gene

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver. Foot NJ, et al. Sci Rep, 2016 Apr 6. PMID 27048792, Free PMC Article
    2. Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells. O'Leary CE, et al. Nat Commun, 2016 Apr 18. PMID 27088444, Free PMC Article
    3. Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein. Konstas AA, et al. J Biol Chem, 2002 Aug 16. PMID 12050153
    4. N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking. Shearwin-Whyatt LM, et al. J Cell Sci, 2004 Jul 15. PMID 15252135
    5. Ndfip Proteins Target Robo Receptors for Degradation and Allow Commissural Axons to Cross the Midline in the Developing Spinal Cord. Gorla M, et al. Cell Rep, 2019 Mar 19. PMID 30893602, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Ndfip2 controls DMT1 in the liver with female mice showing a greater response to altered dietary iron than the male mice
      Title: Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver.
    2. Data indicate thar Janus kinase 1 (Jak1) degradation is dependent on Nedd4 family interacting proteins Ndfip1/Ndfip2.
      Title: Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells.
    3. DMT1 interacts with 2 WW domain-interacting proteins, Ndfip1 and Ndfip2. This promotes DMT1 ubiquitination and degradation by WWP2.
      Title: Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2.
    Submit: New GeneRIF Correction

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • KIAA1165

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables WW domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in perinuclear region of cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    NEDD4 family-interacting protein 2
    Names
    NEDD4 WW domain-binding protein 5A

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190989.2 → NP_001177918.1  NEDD4 family-interacting protein 2

      Status: VALIDATED

      Source sequence(s)
      AC141878
      Consensus CDS
      CCDS49560.2
      UniProtKB/Swiss-Prot
      Q5DTZ9, Q6IR02, Q8BVC5, Q91ZP6
      UniProtKB/TrEMBL
      F6RT43, M0QWK1
      Related
      ENSMUSP00000121854.4, ENSMUST00000138283.3
      Conserved Domains (1) summary
      cl21474
      Location:233 → 300
      ABC2_membrane; ABC-2 type transporter

    2. NM_029561.5 → NP_083837.2  NEDD4 family-interacting protein 2

      Status: VALIDATED

      Source sequence(s)
      AC141878
      Consensus CDS
      CCDS49560.2
      UniProtKB/Swiss-Prot
      Q5DTZ9, Q6IR02, Q8BVC5, Q91ZP6
      UniProtKB/TrEMBL
      F6RT43, M0QWK1
      Related
      ENSMUSP00000137875.2, ENSMUST00000181969.8
      Conserved Domains (1) summary
      cl21474
      Location:233 → 300
      ABC2_membrane; ABC-2 type transporter

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      105495975..105546732
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001781167.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZP6.2 GenPept UniProtKB/Swiss-Prot:Q91ZP6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools