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    Zfp592 zinc finger protein 592 [ Mus musculus (house mouse) ]

    Gene ID: 233410, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp592provided by MGI
    Official Full Name
    zinc finger protein 592provided by MGI
    Primary source
    MGI:MGI:2443541
    See related
    Ensembl:ENSMUSG00000005621 AllianceGenome:MGI:2443541
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf592; A730014M16Rik
    Summary
    Enables PH domain binding activity and insulin receptor substrate binding activity. Acts upstream of or within negative regulation of insulin receptor signaling pathway and regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in nucleus. Is expressed in several structures, including early conceptus; genitourinary system; and neural ectoderm. Orthologous to human ZNF592 (zinc finger protein 592). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 13.4), spleen adult (RPKM 11.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp592 in Genome Data Viewer
    Location:
    7 D3; 7 45.71 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80643432..80694912)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80993684..81045162)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51451 Neighboring gene SEC11 homolog A, signal peptidase complex subunit Neighboring gene STARR-positive B cell enhancer ABC_E2829 Neighboring gene STARR-seq mESC enhancer starr_19348 Neighboring gene predicted gene, 32178 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene STARR-seq mESC enhancer starr_19350 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:88220222-88220409 Neighboring gene alpha-kinase 3 Neighboring gene predicted gene, 51490 Neighboring gene solute carrier family 28 (sodium-coupled nucleoside transporter), member 1 Neighboring gene STARR-seq mESC enhancer starr_19353 Neighboring gene STARR-positive B cell enhancer mm9_chr7:88299922-88300223 Neighboring gene NADH:ubiquinone oxidoreductase subunit S6B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. IRS pleckstrin homology domains bind to acidic motifs in proteins. Burks DJ, et al. J Biol Chem, 1998 Nov 20. PMID 9813005
    2. CAMOS, a nonprogressive, autosomal recessive, congenital cerebellar ataxia, is caused by a mutant zinc-finger protein, ZNF592. Nicolas E, et al. Eur J Hum Genet, 2010 Oct. PMID 20531441, Free PMC Article
    3. DNMT1 interacts with the developmental transcriptional repressor HESX1. Sajedi E, et al. Biochim Biophys Acta, 2008 Jan. PMID 17931718, Free PMC Article
    4. Quantitative trait loci for body size components in mice. Kenney-Hunt JP, et al. Mamm Genome, 2006 Jun. PMID 16783635
    5. Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells. Latos PA, et al. Nat Commun, 2015 Jul 24. PMID 26206133, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0211, 8430405N24

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables PH domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables insulin receptor substrate binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 592

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178707.4 → NP_848822.2  zinc finger protein 592

      Status: VALIDATED

      Source sequence(s)
      AK033364, AK042675, BC094321
      Consensus CDS
      CCDS40003.2
      UniProtKB/Swiss-Prot
      Q80XM1, Q8BHZ4
      UniProtKB/TrEMBL
      Q3UPC8
      Related
      ENSMUSP00000102976.3, ENSMUST00000107353.3
      Conserved Domains (2) summary
      sd00017
      Location:985 → 1005
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam16622
      Location:1149 → 1177
      zf-C2H2_11; zinc-finger C2H2-type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      80643432..80694912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152983.1 → XP_036008876.1  zinc finger protein 592 isoform X1

      UniProtKB/TrEMBL
      Q3UPC8
      Conserved Domains (3) summary
      PTZ00449
      Location:261 → 470
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      sd00017
      Location:994 → 1014
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam16622
      Location:1158 → 1186
      zf-C2H2_11; zinc-finger C2H2-type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BHZ4.3 GenPept UniProtKB/Swiss-Prot:Q8BHZ4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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