Nat1 N-acetyl transferase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nat1provided by MGI
Official Full Name: N-acetyl transferase 1provided by MGI
Primary source: MGI:MGI:97279
See related: Ensembl:ENSMUSG00000025588 AllianceGenome:MGI:97279
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nat-1
Summary: Enables arylamine N-acetyltransferase activity. Predicted to be located in cytoplasm. Is expressed in several structures, including adrenal gland; brain; genitourinary system; submandibular gland; and thymus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); contact dermatitis (multiple); leukemia (multiple); and lung disease (multiple). Orthologous to several human genes including NAT2 (N-acetyltransferase 2). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Note: Loci in other organisms that are functionally homologous to this one are validly referred to as both NAT1 and NAT2; i.e., the functional homologs of NAT1 include mouse and rat Nat2, while the functional homologs of human NAT2 include mouse and rat Nat1. Name:sequence associations are consistent with current use in the field. [13 Feb 2013]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 8 B3.2; 8 33.38 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (67943620..67945183)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (67490968..67492531)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Reduction of mNAT1/hNAT2 Contributes to Cerebral Endothelial Necroptosis and Abeta Accumulation in Alzheimer's Disease.
Title: Reduction of mNAT1/hNAT2 Contributes to Cerebral Endothelial Necroptosis and Aβ Accumulation in Alzheimer's Disease.
metabolic efficiency in arylamine N-acetyltransferase-deficient mice
Title: A readout of metabolic efficiency in arylamine N-acetyltransferase-deficient mice reveals minor energy metabolism changes.
these studies demonstrate that Nat1 deletion promotes reduced mitochondrial activity and is associated with ectopic lipid-induced insulin resistance. These results provide a potential genetic link among mitochondrial dysfunction with increased ectopic lipid deposition, insulin resistance, and type 2 diabetes.
Title: Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice.
Ca(2+)-dependent N-acyltransferase absolutely required Calcium for its activity and the activity was enhanced by phosphatidylserine.
Title: Phosphatidylserine-stimulated production of N-acyl-phosphatidylethanolamines by Ca(2+)-dependent N-acyltransferase.
Nat1 is involved in the translation of proteins that are required for cell differentiation.
Title: Nat1 promotes translation of specific proteins that induce differentiation of mouse embryonic stem cells.
This study illustrated that deficiency of NAT1/2 decreases isoniazid (INH) acetylation, but increases the interactions of INH with endobiotics in the liver.
Title: Deficiency of N-acetyltransferase increases the interactions of isoniazid with endobiotics in mouse liver.
our results suggest that Nat1 deficiency results in mitochondrial dysfunction, which may constitute a mechanistic link between this gene and insulin resistance .
Title: Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice.
Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding.(
Title: Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding.
In adipocytes, Nat1 silencing lowered insulin-mediated glucose uptake, raised lipolysis, and decreased differentiation. Overexpression did the opposite. Nat1(-) mice had high fasting blood glucose, insulin, and triglycerides and low insulin sensitivity.
Title: Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene.
Transfection assays in mice using hydrodynamics-based procedure and reporter gene assay in a mouse cell line revealed that glucocorticoid-induced NAT gene expression is species dependent
Title: Glucocorticoid receptor-mediated transcriptional regulation of N-acetyltransferase 1 gene through distal promoter.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Targeted (2)

General gene information

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Markers

U35885 (e-PCR)
- UniSTS:159768

NoName (e-PCR)
- UniSTS:492572

Nat1 (e-PCR), detects polymorphism
- UniSTS:256625

Nat1 (e-PCR), detects polymorphism
- UniSTS:256626

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-hydroxyarylamine O-acetyltransferase activity	ISO Inferred from Sequence Orthology more info
enables arylamine N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arylamine N-acetyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables arylamine N-acetyltransferase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: arylamine N-acetyltransferase 1

Names: N(alpha)-acetyltransferase 15, NatA auxiliary subunit; N-acetyl transferase 1, liver, blood; N-acetyltransferase type 1; arylamide acetylase 1

NP_032699.1

EC 2.3.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.