Ube2v1 ubiquitin-conjugating enzyme E2 variant 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ube2v1provided by MGI
Official Full Name: ubiquitin-conjugating enzyme E2 variant 1provided by MGI
Primary source: MGI:MGI:1913839
See related: Ensembl:ENSMUSG00000078923 AllianceGenome:MGI:1913839
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CROC1; UEV-1; CROC-1; D7Bwg1382e; 0610011J09Rik
Summary: Enables ubiquitin conjugating enzyme binding activity. Contributes to ubiquitin conjugating enzyme activity. Acts upstream of or within error-free postreplication DNA repair. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of UBC13-MMS2 complex and ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to several human genes including UBE2V1 (ubiquitin conjugating enzyme E2 V1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in stomach adult (RPKM 69.4), frontal lobe adult (RPKM 57.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 87.44 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (167449559..167473933, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (167607639..167632020, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

work reveals that simulated microgravity promotes the apoptotic response through a combined modulation of the Uev1A/TICAM/TRAF/NF-kappaB-regulated apoptosis and the p53/PCNA- and ATM/ATR-Chk1/2-controlled DNA-damage response pathways.
Title: Simulated Microgravity Promotes Cell Apoptosis Through Suppressing Uev1A/TICAM/TRAF/NF-κB-Regulated Anti-Apoptosis and p53/PCNA- and ATM/ATR-Chk1/2-Controlled DNA-Damage Response Pathways.
modification of proteins with Lys(63)-linked ubiquitin chains occurs through a UEV1A-independent substrate modification and UEV1A-dependent Lys(63)-linked ubiquitin chain synthesis mechanism
Title: Substrate modification with lysine 63-linked ubiquitin chains through the UBC13-UEV1A ubiquitin-conjugating enzyme.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC121525P4 (e-PCR)
- UniSTS:270385

D7Bwg1382e (e-PCR), detects polymorphism
- UniSTS:142665

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to ubiquitin conjugating enzyme activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to ubiquitin conjugating enzyme activity	IGI Inferred from Genetic Interaction more info	PubMed
enables ubiquitin conjugating enzyme binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within error-free postreplication DNA repair	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in postreplication repair	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K63-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K63-linked ubiquitination	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of UBC13-MMS2 complex	ISO Inferred from Sequence Orthology more info
part_of UBC13-MMS2 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of ubiquitin conjugating enzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of ubiquitin conjugating enzyme complex	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ubiquitin-conjugating enzyme E2 variant 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001311131.1 → NP_001298060.1 ubiquitin-conjugating enzyme E2 variant 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK158230, CF171728

Consensus CDS

CCDS79868.1

UniProtKB/TrEMBL

B7ZBY7

Related

ENSMUSP00000114764.2, ENSMUST00000151365.8

Conserved Domains (1) summary

smart00212
Location:42 → 168

UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues
NM_001311146.1 → NP_001298075.1 ubiquitin-conjugating enzyme E2 variant 1 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an internal exon in the 5' coding region and lacks an exon in the 3' coding region compred to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus compared to isoform 1.

Source sequence(s)

AL589870

Consensus CDS

CCDS79869.1

UniProtKB/Swiss-Prot

Q9CZY3

Related

ENSMUSP00000053109.7, ENSMUST00000060645.13

Conserved Domains (1) summary

cl00154
Location:16 → 100

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
NM_023230.2 → NP_075719.1 ubiquitin-conjugating enzyme E2 variant 1 isoform 2

See identical proteins and their annotated locations for NP_075719.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an internal exon which results in the use of an alternate start codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.

Source sequence(s)

AK158230

Consensus CDS

CCDS17103.1

UniProtKB/Swiss-Prot

A2A467, Q8VEB5, Q9CZY3, Q9ERI7

UniProtKB/TrEMBL

Q569Y6

Related

ENSMUSP00000104830.4, ENSMUST00000109207.10

Conserved Domains (1) summary

smart00212
Location:16 → 142

UBCc; Ubiquitin-conjugating enzyme E2, catalytic domain homologues

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

167449559..167473933 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006500014.5 → XP_006500077.1 ubiquitin-conjugating enzyme E2 variant 1 isoform X1

Conserved Domains (1) summary

cl00154
Location:42 → 126

UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...