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    Ccdc80 coiled-coil domain containing 80 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64387, updated on 27-Nov-2024

    Summary

    Official Symbol
    Ccdc80provided by RGD
    Official Full Name
    coiled-coil domain containing 80provided by RGD
    Primary source
    RGD:69421
    See related
    EnsemblRapid:ENSRNOG00000002052 AllianceGenome:RGD:69421
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    CL2; Dro1; Ssg1
    Summary
    Predicted to enable fibronectin binding activity and heparin binding activity. Predicted to be involved in extracellular matrix organization and positive regulation of cell-substrate adhesion. Predicted to act upstream of or within response to bacterium. Predicted to be located in interstitial matrix. Predicted to be active in basement membrane. Orthologous to human CCDC80 (coiled-coil domain containing 80). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 582.4), Uterus (RPKM 319.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ccdc80 in Genome Data Viewer
    Location:
    11q21
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 11 NC_086029.1 (69191188..69224844, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 11 NC_051346.1 (55685165..55718827, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 11 NC_005110.4 (60645660..60679249, complement)

    Chromosome 11 - NC_086029.1Genomic Context describing neighboring genes Neighboring gene autophagy related 3 Neighboring gene solute carrier family 35, member A5 Neighboring gene uncharacterized LOC102551825 Neighboring gene uncharacterized LOC102551884

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables fibronectin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables glycosaminoglycan binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heparin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within extracellular matrix organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cell-substrate adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of cell-substrate adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within response to bacterium ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    is_active_in basement membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basement membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular matrix ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in interstitial matrix ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    coiled-coil domain-containing protein 80
    Names
    SSG-1
    down-regulated by oncogenes 1 protein
    steroid sensitive gene 1
    steroid-sensitive gene 1 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022543.2NP_071988.2  coiled-coil domain-containing protein 80 precursor

      See identical proteins and their annotated locations for NP_071988.2

      Status: VALIDATED

      Source sequence(s)
      AF223677, AY548105, CB322543
      UniProtKB/Swiss-Prot
      Q6IRG8, Q6QD51, Q9JKW4
      UniProtKB/TrEMBL
      A6IQZ5
      Related
      ENSRNOP00000056490.2, ENSRNOT00000059735.5
      Conserved Domains (1) summary
      pfam13778
      Location:770899
      DUF4174; Domain of unknown function (DUF4174)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086029.1 Reference GRCr8

      Range
      69191188..69224844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)