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    Serp2 stress-associated endoplasmic reticulum protein family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 72661, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Serp2provided by MGI
    Official Full Name
    stress-associated endoplasmic reticulum protein family member 2provided by MGI
    Primary source
    MGI:MGI:1919911
    See related
    Ensembl:ENSMUSG00000052584 AllianceGenome:MGI:1919911
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2810032E02Rik
    Summary
    Predicted to be involved in endoplasmic reticulum unfolded protein response. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum. Orthologous to human SERP2 (stress associated endoplasmic reticulum protein family member 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 32.4), cortex adult (RPKM 27.7) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Serp2 in Genome Data Viewer
    Location:
    14 D3; 14 40.44 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (76770252..76794518, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (76532812..76557074, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene TSC22 domain family, member 1 Neighboring gene STARR-seq mESC enhancer starr_37176 Neighboring gene STARR-seq mESC enhancer starr_37178 Neighboring gene STARR-seq mESC enhancer starr_37179 Neighboring gene STARR-positive B cell enhancer ABC_E2428 Neighboring gene STARR-seq mESC enhancer starr_37180 Neighboring gene RIKEN cDNA 4930444M15 gene Neighboring gene STARR-seq mESC enhancer starr_37182 Neighboring gene predicted gene, 36845 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:76966575-76966812 Neighboring gene STARR-seq mESC enhancer starr_37187 Neighboring gene RIKEN cDNA 1700105F02 gene Neighboring gene FK506 binding protein 1a, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_37190 Neighboring gene STARR-seq mESC enhancer starr_37191

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A comparison of whole-genome shotgun-derived mouse chromosome 16 and the human genome. Mural RJ, et al. Science, 2002 May 31. PMID 12040188
    2. USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities. Liu C, et al. Sci Adv, 2023 May 19. PMID 37196079, Free PMC Article
    3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC118314

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum unfolded protein response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    stress-associated endoplasmic reticulum protein 2
    Names
    ribosome-associated membrane protein RAMP4-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160326.1 → NP_001153798.1  stress-associated endoplasmic reticulum protein 2 isoform 1

      See identical proteins and their annotated locations for NP_001153798.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein coding transcript.
      Source sequence(s)
      BU057067, CF728547
      Consensus CDS
      CCDS49546.1
      UniProtKB/Swiss-Prot
      Q497L0, Q6TAW2
      Related
      ENSMUSP00000068508.8, ENSMUST00000064517.9
      Conserved Domains (1) summary
      pfam06624
      Location:2 → 58
      RAMP4; Ribosome associated membrane protein RAMP4

    2. NM_001360046.2 → NP_001346975.1  stress-associated endoplasmic reticulum protein 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC142266
      Conserved Domains (1) summary
      pfam06624
      Location:55 → 111
      RAMP4; Ribosome associated membrane protein RAMP4

    3. NM_001360047.1 → NP_001346976.1  stress-associated endoplasmic reticulum protein 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AV495881, BU057067, CF728547
      Conserved Domains (1) summary
      pfam06624
      Location:2 → 28
      RAMP4; Ribosome associated membrane protein RAMP4

    4. NM_001360048.2 → NP_001346977.1  stress-associated endoplasmic reticulum protein 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC142266
      Conserved Domains (1) summary
      pfam06624
      Location:55 → 81
      RAMP4; Ribosome associated membrane protein RAMP4

    RNA

    1. NR_027699.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains alternate exons at the 5' end and an additional internal exon compared to variant 1. This results in translational start from an in-frame upstream AUG, and early translation termination, rendering this transcript a candidate for nonsense-mediated mRNA decay (NMD). The transcript is sufficiently abundant to represent as a RefSeq record.
      Source sequence(s)
      AC142266
      Related
      ENSMUST00000227076.2

    2. NR_153389.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AV495881, BU057067, CF728547

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      76770252..76794518 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030248046.2 → XP_030103906.1  stress-associated endoplasmic reticulum protein 2 isoform X1

      Conserved Domains (1) summary
      pfam06624
      Location:56 → 81
      RAMP4; Ribosome associated membrane protein RAMP4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6TAW2.2 GenPept UniProtKB/Swiss-Prot:Q6TAW2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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