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    rom-3 Peptidase S54 rhomboid domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 191000, updated on 4-Jan-2025

    Summary

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    Official Symbol
    rom-3
    Official Full Name
    Peptidase S54 rhomboid domain-containing protein
    Primary source
    WormBase:WBGene00004402
    Locus tag
    CELE_Y116A8C.14
    See related
    AllianceGenome:WB:WBGene00004402
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in regulation of epidermal growth factor receptor signaling pathway and regulation of protein secretion. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in palmoplantar keratoderma-esophageal carcinoma syndrome. Orthologous to human RHBDF1 (rhomboid 5 homolog 1) and RHBDF2 (rhomboid 5 homolog 2). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See rom-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    13
    Sequence:
    Chromosome: IV; NC_003282.8 (16965284..16970490, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor 6 Neighboring gene DNA repair and recombination protein RAD54-like Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboid. Dutt A, et al. PLoS Biol, 2004 Nov. PMID 15455032, Free PMC Article
    2. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Peptidase S54 rhomboid domain-containing protein
    NP_001299966.1
    • Partially confirmed by transcript evidence
    NP_503013.2
    • Partially confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      16965284..16970490 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_070612.2 → NP_503013.2  Peptidase S54 rhomboid domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_503013.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U2S3
      Conserved Domains (1) summary
      pfam01694
      Location:582 → 725
      Rhomboid; Rhomboid family

    2. NM_001313037.1 → NP_001299966.1  Peptidase S54 rhomboid domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0K3AV34
      Conserved Domains (1) summary
      pfam01694
      Location:263 → 406
      Rhomboid; Rhomboid family
    Nucleotide Protein
    Heading Accession and Version

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