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    SIM1 SIM bHLH transcription factor 1 [ Gallus gallus (chicken) ]

    Gene ID: 396129, updated on 3-Dec-2024

    Summary

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    Symbol
    SIM1provided by CGNC
    Full Name
    SIM bHLH transcription factor 1provided by CGNC
    Primary source
    CGNC:49663
    See related
    Ensembl:ENSGALG00010015160
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See SIM1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (70646809..70693397)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (70421509..70468067)

    Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene glutamate ionotropic receptor kainate type subunit 2 Neighboring gene uncharacterized LOC101751234 Neighboring gene activating signal cointegrator 1 complex subunit 3 Neighboring gene PR/SET domain 13 Neighboring gene cyclin C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Lateral and axial signals involved in avian somite patterning: a role for BMP4. Pourquié O, et al. Cell, 1996 Feb 9. PMID 8608600
    2. Sim1 and Sim2 expression during chick and mouse limb development. Coumailleau P, et al. Int J Dev Biol, 2009. PMID 19123137
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    single-minded homolog 1
    Names
    single-minded family bHLH transcription factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      70646809..70693397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040697741.2 → XP_040553675.1  single-minded homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YT56
      Conserved Domains (3) summary
      cd00130
      Location:118 → 188
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:273 → 359
      PAS_3; PAS fold
      cd19738
      Location:1 → 71
      bHLH-PAS_SIM1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in single-minded homolog 1 (SIM1) and similar proteins

    2. XM_004940356.5 → XP_004940413.1  single-minded homolog 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YT56, E1C5G3
      Related
      ENSGALP00010021284.1, ENSGALT00010036535.1
      Conserved Domains (4) summary
      cd00130
      Location:88 → 158
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:243 → 329
      PAS_3; PAS fold
      cd19738
      Location:1 → 71
      bHLH-PAS_SIM1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in single-minded homolog 1 (SIM1) and similar proteins
      pfam06621
      Location:359 → 669
      SIM_C; Single-minded protein C-terminus

    3. XM_046939179.1 → XP_046795135.1  single-minded homolog 1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YT56

    4. XM_004940357.5 → XP_004940414.1  single-minded homolog 1 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YT56
      Related
      ENSGALP00010021280.1, ENSGALT00010036531.1
      Conserved Domains (3) summary
      cd00130
      Location:1 → 57
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:142 → 228
      PAS_3; PAS fold
      pfam06621
      Location:258 → 568
      SIM_C; Single-minded protein C-terminus

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      70421509..70468067
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040666557.2 → XP_040522491.1  single-minded homolog 1 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YT56
      Conserved Domains (3) summary
      cd00130
      Location:118 → 188
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:273 → 359
      PAS_3; PAS fold
      cd19738
      Location:1 → 71
      bHLH-PAS_SIM1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in single-minded homolog 1 (SIM1) and similar proteins

    2. XM_040666559.2 → XP_040522493.1  single-minded homolog 1 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YT56, E1C5G3
      Conserved Domains (4) summary
      cd00130
      Location:88 → 158
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:243 → 329
      PAS_3; PAS fold
      cd19738
      Location:1 → 71
      bHLH-PAS_SIM1; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in single-minded homolog 1 (SIM1) and similar proteins
      pfam06621
      Location:359 → 669
      SIM_C; Single-minded protein C-terminus

    3. XM_046914585.1 → XP_046770541.1  single-minded homolog 1 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YT56

    4. XM_040666560.2 → XP_040522494.1  single-minded homolog 1 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YT56
      Conserved Domains (3) summary
      cd00130
      Location:1 → 57
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      pfam08447
      Location:142 → 228
      PAS_3; PAS fold
      pfam06621
      Location:258 → 568
      SIM_C; Single-minded protein C-terminus
    Nucleotide Protein
    Heading Accession and Version

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