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    Sec14l2 SEC14-like lipid binding 2 [ Mus musculus (house mouse) ]

    Gene ID: 67815, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Sec14l2provided by MGI
    Official Full Name
    SEC14-like lipid binding 2provided by MGI
    Primary source
    MGI:MGI:1915065
    See related
    Ensembl:ENSMUSG00000003585 AllianceGenome:MGI:1915065
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Spf; TAP; 1300013M05Rik
    Summary
    Predicted to enable enzyme activator activity and transferase activity, transferring alkyl or aryl (other than methyl) groups. Predicted to be involved in positive regulation of cholesterol biosynthetic process. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in 1st branchial arch maxillary component; nasal pit; otocyst; and trunk somite. Orthologous to human SEC14L2 (SEC14 like lipid binding 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 140.8), liver E18 (RPKM 27.5) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sec14l2 in Genome Data Viewer
    Location:
    11 A1; 11 2.87 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (4047039..4068729, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (4097039..4118729, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene SEC14-like lipid binding 3 Neighboring gene predicted gene, 51935 Neighboring gene STARR-seq mESC enhancer starr_28370 Neighboring gene mitochondrial fission process 1 Neighboring gene predicted gene, 51934 Neighboring gene transformer 2 beta homolog pseudogene Neighboring gene ring finger protein 215 Neighboring gene microRNA 3060

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulation of hepatic cholesterol synthesis by a novel protein (SPF) that accelerates cholesterol biosynthesis. Shibata N, et al. FASEB J, 2006 Dec. PMID 17077281
    2. Interactions of supernatant protein factor with components of the microsomal squalene epoxidase system. Binding of supernatant protein factor to anionic phospholipids. Caras IW, et al. J Biol Chem, 1980 Apr 25. PMID 7364757
    3. A novel human tocopherol-associated protein: cloning, in vitro expression, and characterization. Zimmer S, et al. J Biol Chem, 2000 Aug 18. PMID 10829015
    4. Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis. Shibata N, et al. Proc Natl Acad Sci U S A, 2001 Feb 27. PMID 11226224, Free PMC Article
    5. Tocopherol-associated protein is a ligand-dependent transcriptional activator. Yamauchi J, et al. Biochem Biophys Res Commun, 2001 Jul 13. PMID 11444841

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables enzyme activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring alkyl or aryl (other than methyl) groups ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SEC14-like protein 2
    Names
    SEC14-like 2
    alpha-tocopherol-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144520.2 → NP_653103.1  SEC14-like protein 2

      See identical proteins and their annotated locations for NP_653103.1

      Status: PROVISIONAL

      Source sequence(s)
      AL807395
      Consensus CDS
      CCDS24377.1
      UniProtKB/Swiss-Prot
      Q99J08
      Related
      ENSMUSP00000003681.8, ENSMUST00000003681.8
      Conserved Domains (3) summary
      smart00516
      Location:76 → 244
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      smart01100
      Location:13 → 59
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      pfam13897
      Location:300 → 381
      GOLD_2; Golgi-dynamics membrane-trafficking

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      4047039..4068729 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99J08.1 GenPept UniProtKB/Swiss-Prot:Q99J08

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