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    LOC106694315 MPO proximal enhancer and promoter region [ Homo sapiens (human) ]

    Gene ID: 106694315, updated on 10-Dec-2024

    Summary

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    Gene symbol
    LOC106694315
    Gene description
    MPO proximal enhancer and promoter region
    Gene type
    biological region
    Feature type(s)
    protein_bind
    regulatory: DNase_I_hypersensitive_site, enhancer, promoter, response_element
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This region contains multiple DNase I hypersensitive sites that overlap with promoters and other regulatory regions for the MPO (myeloperoxidase) gene. These sequences can be activated by granulocyte-colony stimulating factor (G-CSF) and suppressed by interleukin 3. The P1 promoter binds HMG-box transcription factor 1, while the NF-Y heterotrimer interacts with an upstream regulatory element. In vivo transcription occurs predominantly through the P1 promoter. [provided by RefSeq, Oct 2015]
    Orthologs
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    Genomic context

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    See LOC106694315 in Genome Data Viewer
    Location:
    chromosome: 17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (58279588..58282434)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (59147467..59150313)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (56356949..56359795)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12461 Neighboring gene uncharacterized LOC105371841 Neighboring gene uncharacterized LOC124904038 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:56326145-56326710 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12462 Neighboring gene lactoperoxidase Neighboring gene enhancer region in introns 7-9 of MPO Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:56355955-56356644 Neighboring gene MPO upstream enhancer region Neighboring gene myeloperoxidase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:56379736-56380356 Neighboring gene Sharpr-MPRA regulatory region 10051 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:56386896-56387595 Neighboring gene TSPO associated protein 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:56389497-56390115 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8761 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:56402416-56402964 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8764 Neighboring gene TSPOAP1, SUPT4H1 and RNF43 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12463 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8765 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12464 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12466 Neighboring gene MIR142 host genes Neighboring gene microRNA 142

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional activity of three distinct myeloperoxidase (MPO) promoters in human myeloid cells. Lin KM, et al. Leukemia, 2002 Jun. PMID 12040446
    2. Cloning and expression of human HBP1, a high mobility group protein that enhances myeloperoxidase (MPO) promoter activity. Lin KM, et al. Leukemia, 2001 Apr. PMID 11368363
    3. Molecular analysis of the human myeloperoxidase promoter region. Chumakov AM, et al. Int J Oncol, 2000 Feb. PMID 10639585
    4. Cis-elements in the promoter region of the human myeloperoxidase (MPO) gene. Zhao WG, et al. Leukemia, 1996 Jul. PMID 8683986
    5. Sequence comparison of putative regulatory DNA of the 5' flanking region of the myeloperoxidase gene in normal and leukemic bone marrow cells. Austin GE, et al. Leukemia, 1993 Sep. PMID 8396697

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See Variation Viewer (GRCh37.p13)

    General gene information

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    Homology

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_044959.1 

      Range
      101..2947
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      58279588..58282434
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      59147467..59150313
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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