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    Sox10-mcs1c/2 MCS1C/MCS2 enhancer region 5' of Sox10 [ Mus musculus (house mouse) ]

    Gene ID: 107966123, updated on 9-Aug-2024

    Summary

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    Gene symbol
    Sox10-mcs1c/2
    Gene description
    MCS1C/MCS2 enhancer region 5' of Sox10
    Gene type
    biological region
    Feature type(s)
    protein_bind
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    U5; MCS2; MCS1C; Rr366667; Sox10-MCS2; Sox10-MCS1C
    Summary
    This region contains conserved enhancer elements located upstream of the SRY-box 10 (Sox10) gene. These elements can drive expression of a transgene in tissues that express Sox10, including the ganglia, otic vesicle, and Schwann cells. [provided by RefSeq, Sep 2016]
    Orthologs
    human all
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    Genomic context

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    See Sox10-mcs1c/2 in Genome Data Viewer
    Location:
    chromosome: 15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79048547..79050741)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79164347..79166541)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing -like 1 Neighboring gene RIKEN cDNA 1700088E04 gene Neighboring gene STARR-positive B cell enhancer ABC_E7388 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide F Neighboring gene D6 enhancer downstream of Sox10 Neighboring gene SRY (sex determining region Y)-box 10 Neighboring gene predicted gene 10863 Neighboring gene predicted gene, 53902 Neighboring gene Sox10 multiple-species conserved sequence 4 Neighboring gene Sox10 multiple-species conserved sequence 5 Neighboring gene Sox10 multiple-species conserved sequence 7 Neighboring gene Sox10 multiple-species conserved sequence 8 Neighboring gene STARR-seq mESC enhancer starr_39171 Neighboring gene predicted gene, 52189 Neighboring gene Sox10 multiple-species conserved sequence 9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple conserved regulatory elements with overlapping functions determine Sox10 expression in mouse embryogenesis. Werner T, et al. Nucleic Acids Res, 2007. PMID 17897962, Free PMC Article
    2. Identification of neural crest and glial enhancers at the mouse Sox10 locus through transgenesis in zebrafish. Antonellis A, et al. PLoS Genet, 2008 Sep 5. PMID 18773071, Free PMC Article
    3. Distant regulatory elements in a Sox10-beta GEO BAC transgene are required for expression of Sox10 in the enteric nervous system and other neural crest-derived tissues. Deal KK, et al. Dev Dyn, 2006 May. PMID 16586440

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Other Names

    • Sox10 multiple-species conserved sequence 1C
    • Sox10 multiple-species conserved sequence 2
    • regulatory region 366667

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_050695.1 

      Range
      101..2295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      79048547..79050741
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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