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    ZNF148 zinc finger protein 148 [ Homo sapiens (human) ]

    Gene ID: 7707, updated on 9-Dec-2024

    Summary

    Official Symbol
    ZNF148provided by HGNC
    Official Full Name
    zinc finger protein 148provided by HGNC
    Primary source
    HGNC:HGNC:12933
    See related
    Ensembl:ENSG00000163848 MIM:601897; AllianceGenome:HGNC:12933
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BERF-1; BFCOL1; GDACCF; ZBP-89; ZFP148; pHZ-52; HT-BETA
    Summary
    The protein encoded by this gene is a member of the Kruppel family of zinc finger DNA binding proteins. The encoded protein activates transcription of the T-cell receptor and intestinal alkaline phosphatase genes but represses transcription of the ornithine decarboxylase, vimentin, gastrin, stomelysin, and enolase genes. Increased expression of this gene results in decreased patient survival rates from colorectal cancer, while mutations in this gene have been associated with global developmental delay, hypoplastic corpus callosum, and dysmorphic facies. [provided by RefSeq, Feb 2017]
    Expression
    Ubiquitous expression in thyroid (RPKM 14.7), ovary (RPKM 6.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See ZNF148 in Genome Data Viewer
    Location:
    3q21.2
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (125225669..125375354, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (127952391..128102007, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (124944513..125094198, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene solute carrier family 12 member 8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20416 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:124839347-124839853 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:124839854-124840359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20417 Neighboring gene RNA, U6 small nuclear 230, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:124860668-124861491 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14661 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:124862005-124862958 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20425 Neighboring gene NANOG hESC enhancer GRCh37_chr3:124872987-124873488 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14662 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20426 Neighboring gene microRNA 5092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20427 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:124930713-124931312 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14664 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14665 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:124950809-124952008 Neighboring gene NANOG hESC enhancer GRCh37_chr3:125058886-125059484 Neighboring gene deoxyuridine triphosphatase pseudogene 1 Neighboring gene DNAJB6 pseudogene 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125087248-125087748 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:125087749-125088249 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20428 Neighboring gene uncharacterized LOC105374080 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20429 Neighboring gene RNA, U6 small nuclear 232, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of zinc finger protein 148 (ZNF148) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp686L18248

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 148
    Names
    CACCC box-binding protein
    CLL-associated antigen KW-10
    transcription factor ZBP-89
    zinc finger DNA-binding protein 89

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052987.1 RefSeqGene

      Range
      5030..154686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001348424.1NP_001335353.1  zinc finger protein 148 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1-11 all encode the same isoform (a).
      Source sequence(s)
      AC108688
      Consensus CDS
      CCDS3031.1
      UniProtKB/Swiss-Prot
      D3DN27, O00389, O43591, Q58EY5, Q6PJ98, Q9UQR1
      UniProtKB/TrEMBL
      Q8TDH4
      Conserved Domains (3) summary
      sd00017
      Location:173193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:171193
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:214238
      zf-H2C2_2; Zinc-finger double domain
    2. NM_001348425.2NP_001335354.1  zinc finger protein 148 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-11 all encode the same isoform (a).
      Source sequence(s)
      AA481164, AC108688, BC050260, DA726996
      Consensus CDS
      CCDS3031.1
      UniProtKB/Swiss-Prot
      D3DN27, O00389, O43591, Q58EY5, Q6PJ98, Q9UQR1
      UniProtKB/TrEMBL
      Q8TDH4
      Related
      ENSP00000420448.1, ENST00000485866.5
      Conserved Domains (3) summary
      sd00017
      Location:173193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:171193
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:214238
      zf-H2C2_2; Zinc-finger double domain
    3. NM_001348426.2NP_001335355.1  zinc finger protein 148 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-11 all encode the same isoform (a).
      Source sequence(s)
      AA481164, AC108688, BM917104, BQ441085, N27696
      Consensus CDS
      CCDS3031.1
      UniProtKB/Swiss-Prot
      D3DN27, O00389, O43591, Q58EY5, Q6PJ98, Q9UQR1
      UniProtKB/TrEMBL
      Q8TDH4
      Conserved Domains (3) summary
      sd00017
      Location:173193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:171193
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:214238
      zf-H2C2_2; Zinc-finger double domain
    4. NM_001348427.2NP_001335356.1  zinc finger protein 148 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-11 all encode the same isoform (a).
      Source sequence(s)
      AA481164, AC108688, AU121036, BM917104, BP237604, DA225087
      Consensus CDS
      CCDS3031.1
      UniProtKB/Swiss-Prot
      D3DN27, O00389, O43591, Q58EY5, Q6PJ98, Q9UQR1
      UniProtKB/TrEMBL
      Q8TDH4
      Related
      ENSP00000420038.2, ENST00000471196.2
      Conserved Domains (3) summary
      sd00017
      Location:173193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:171193
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:214238
      zf-H2C2_2; Zinc-finger double domain
    5. NM_001348428.2NP_001335357.1  zinc finger protein 148 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-11 all encode the same isoform (a).
      Source sequence(s)
      AA481164, AC108688, AU121036, BM917104, BP237604, DA780458, DB145818
      Consensus CDS
      CCDS3031.1
      UniProtKB/Swiss-Prot
      D3DN27, O00389, O43591, Q58EY5, Q6PJ98, Q9UQR1
      UniProtKB/TrEMBL
      Q8TDH4
      Conserved Domains (3) summary
      sd00017
      Location:173193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:171193
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:214238
      zf-H2C2_2; Zinc-finger double domain
    6. NM_001348429.2NP_001335358.1  zinc finger protein 148 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-11 all encode the same isoform (a).
      Source sequence(s)
      AA481164, AC108688, BQ441085, BU178504
      Consensus CDS
      CCDS3031.1
      UniProtKB/Swiss-Prot
      D3DN27, O00389, O43591, Q58EY5, Q6PJ98, Q9UQR1
      UniProtKB/TrEMBL
      Q8TDH4
      Conserved Domains (3) summary
      sd00017
      Location:173193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:171193
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:214238
      zf-H2C2_2; Zinc-finger double domain
    7. NM_001348430.2NP_001335359.1  zinc finger protein 148 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-11 all encode the same isoform (a).
      Source sequence(s)
      AA481164, AC108688, AF432210, BQ674550
      Consensus CDS
      CCDS3031.1
      UniProtKB/Swiss-Prot
      D3DN27, O00389, O43591, Q58EY5, Q6PJ98, Q9UQR1
      UniProtKB/TrEMBL
      Q8TDH4
      Related
      ENSP00000420335.1, ENST00000484491.5
      Conserved Domains (3) summary
      sd00017
      Location:173193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:171193
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:214238
      zf-H2C2_2; Zinc-finger double domain
    8. NM_001348431.2NP_001335360.1  zinc finger protein 148 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-11 all encode the same isoform (a).
      Source sequence(s)
      AA481164, AC108688, BQ441085, BU178504, CR980884
      Consensus CDS
      CCDS3031.1
      UniProtKB/Swiss-Prot
      D3DN27, O00389, O43591, Q58EY5, Q6PJ98, Q9UQR1
      UniProtKB/TrEMBL
      Q8TDH4
      Related
      ENSP00000419322.1, ENST00000492394.5
      Conserved Domains (3) summary
      sd00017
      Location:173193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:171193
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:214238
      zf-H2C2_2; Zinc-finger double domain
    9. NM_001348432.2NP_001335361.1  zinc finger protein 148 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1-11 all encode the same isoform (a).
      Source sequence(s)
      AA481164, AC108688, BQ441085, BU178504, DA780458
      Consensus CDS
      CCDS3031.1
      UniProtKB/Swiss-Prot
      D3DN27, O00389, O43591, Q58EY5, Q6PJ98, Q9UQR1
      UniProtKB/TrEMBL
      Q8TDH4
      Related
      ENSP00000514760.1, ENST00000700044.1
      Conserved Domains (3) summary
      sd00017
      Location:173193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:171193
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:214238
      zf-H2C2_2; Zinc-finger double domain
    10. NM_001348433.2NP_001335362.1  zinc finger protein 148 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR compared to variant 1. Variants 1-11 all encode the same isoform (a).
      Source sequence(s)
      AA481164, AC108688, BP378362, BU178504, BU941780, CV571288
      Consensus CDS
      CCDS3031.1
      UniProtKB/Swiss-Prot
      D3DN27, O00389, O43591, Q58EY5, Q6PJ98, Q9UQR1
      UniProtKB/TrEMBL
      Q8TDH4
      Conserved Domains (3) summary
      sd00017
      Location:173193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:171193
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:214238
      zf-H2C2_2; Zinc-finger double domain
    11. NM_001348434.2NP_001335363.1  zinc finger protein 148 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AA481164, AC108688, AU121036, BM917104, DA492993
      UniProtKB/TrEMBL
      Q8TDH4
      Conserved Domains (3) summary
      sd00017
      Location:131151
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:129151
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:172196
      zf-H2C2_2; Zinc-finger double domain
    12. NM_001348436.2NP_001335365.1  zinc finger protein 148 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 1. The resulting isoform (c) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AC108688, BC050260, DA726996, GD148926
      Related
      ENST00000700212.1
      Conserved Domains (3) summary
      COG5048
      Location:166231
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:173193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:185210
      zf-H2C2_2; Zinc-finger double domain
    13. NM_021964.3NP_068799.2  zinc finger protein 148 isoform a

      See identical proteins and their annotated locations for NP_068799.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-11 all encode the same isoform (a).
      Source sequence(s)
      AC108688
      Consensus CDS
      CCDS3031.1
      UniProtKB/Swiss-Prot
      D3DN27, O00389, O43591, Q58EY5, Q6PJ98, Q9UQR1
      UniProtKB/TrEMBL
      Q8TDH4
      Related
      ENSP00000353863.4, ENST00000360647.9
      Conserved Domains (3) summary
      sd00017
      Location:173193
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:171193
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:214238
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      125225669..125375354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      127952391..128102007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)