Syt9 synaptotagmin IX [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Syt9provided by MGI
Official Full Name: synaptotagmin IXprovided by MGI
Primary source: MGI:MGI:1926373
See related: Ensembl:ENSMUSG00000062542 AllianceGenome:MGI:1926373
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables SNARE binding activity; identical protein binding activity; and phospholipid binding activity. Involved in calcium-dependent activation of synaptic vesicle fusion and regulation of calcium ion-dependent exocytosis. Located in dense core granule. Is active in hippocampal mossy fiber to CA3 synapse and synaptic vesicle membrane. Is expressed in several structures, including adrenal gland; gonad; liver; nervous system; and spleen. Orthologous to human SYT9 (synaptotagmin 9). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cerebellum adult (RPKM 9.2), CNS E18 (RPKM 4.9) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E3; 7 56.33 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (106969929..107147863)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (107370349..107548656)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic ablation of synaptotagmin-9 alters tomosyn-1 function to increase insulin secretion from pancreatic beta-cells improving glucose clearance.
Title: Genetic ablation of synaptotagmin-9 alters tomosyn-1 function to increase insulin secretion from pancreatic β-cells improving glucose clearance.
The Cytidine N-Acetyltransferase NAT10 Participates in Peripheral Nerve Injury-Induced Neuropathic Pain by Stabilizing SYT9 Expression in Primary Sensory Neurons.
Title: The Cytidine N-Acetyltransferase NAT10 Participates in Peripheral Nerve Injury-Induced Neuropathic Pain by Stabilizing SYT9 Expression in Primary Sensory Neurons.
Synaptotagmin 9 Modulates Spontaneous Neurotransmitter Release in Striatal Neurons by Regulating Substance P Secretion.
Title: Synaptotagmin 9 Modulates Spontaneous Neurotransmitter Release in Striatal Neurons by Regulating Substance P Secretion.
expressed in a subpopulation of anterior pituitary cells, the gonadotropes
Title: Sex-specific regulation of follicle-stimulating hormone secretion by synaptotagmin 9.
Syt-9 interacted with APP in cells and in mouse brains in vivo, promoting Abeta generation.
Title: Synaptotagmins interact with APP and promote Aβ generation.
Data show that synaptotagmin-9 is not involved in the regulation of glucose-stimulated insulin release from pancreatic beta-cells.
Title: Neuronal calcium sensor synaptotagmin-9 is not involved in the regulation of glucose homeostasis or insulin secretion.
Data indicate that Cspalpha interacts with Syt9, and such a complex may be relevant in the calcium-mediated control of a late stage of exocytosis by triggering the specific recruitment of a folding catalyst at the fusion point.
Title: A charged prominence in the linker domain of the cysteine-string protein Cspα mediates its regulated interaction with the calcium sensor synaptotagmin 9 during exocytosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

General gene information

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Markers

AW049067 (e-PCR)
- UniSTS:208182

RH141563 (e-PCR)
- UniSTS:223557

D7Mit262 (e-PCR), detects polymorphism
- UniSTS:131158

D7Mit324 (e-PCR), detects polymorphism
- UniSTS:131226

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables SNARE binding	IBA Inferred from Biological aspect of Ancestor more info
enables SNARE binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion sensor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylserine binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium-dependent activation of synaptic vesicle fusion	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium-dependent activation of synaptic vesicle fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vesicle fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of calcium ion-dependent exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of calcium ion-dependent exocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of calcium ion-dependent exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in dense core granule	IBA Inferred from Biological aspect of Ancestor more info
located_in dense core granule	IDA Inferred from Direct Assay more info	PubMed
located_in dense core granule	ISO Inferred from Sequence Orthology more info
is_active_in exocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in hippocampal mossy fiber to CA3 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IEP Inferred from Expression Pattern more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in secretory granule	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle membrane	IEP Inferred from Expression Pattern more info	PubMed
is_active_in synaptic vesicle membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: synaptotagmin-9

Names: synaptotagmin V; sytIX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_021889.5 → NP_068689.2 synaptotagmin-9

See identical proteins and their annotated locations for NP_068689.2

Status: VALIDATED

Source sequence(s)

AC127431, AC164638

Consensus CDS

CCDS40078.1

UniProtKB/Swiss-Prot

Q3U0R7, Q8C280, Q9R0N9

Related

ENSMUSP00000073164.6, ENSMUST00000073459.12

Conserved Domains (2) summary

cd08403
Location:354 → 487

C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

cl14603
Location:221 → 345

C2; C2 domain

RNA

NR_184790.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC127431, AC164638

Related

ENSMUST00000130414.8
NR_184791.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC127431, AC164638
NR_184792.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC127431, AC164638