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    Prrc2c proline-rich coiled-coil 2C [ Mus musculus (house mouse) ]

    Gene ID: 226562, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Prrc2cprovided by MGI
    Official Full Name
    proline-rich coiled-coil 2Cprovided by MGI
    Primary source
    MGI:MGI:1913754
    See related
    Ensembl:ENSMUSG00000040225 AllianceGenome:MGI:1913754
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bat2d; Prrc3; Bat2d1; Bat2l2; mKIAA1096; A630006J20; 1810043M20Rik; 9630039I18Rik; E130112L15Rik
    Summary
    Acts upstream of or within hematopoietic progenitor cell differentiation. Predicted to be located in cytosol. Is expressed in brain; cerebral cortex ventricular layer; cortical plate; lung; and main olfactory bulb. Orthologous to human PRRC2C (proline rich coiled-coil 2C). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 26.1), limb E14.5 (RPKM 16.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prrc2c in Genome Data Viewer
    Location:
    1 H2.1; 1 70.3 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (162499354..162568125, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (162671785..162740560, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4E family member 1B pseudogene Neighboring gene myocilin Neighboring gene myocilin opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:164658175-164658482 Neighboring gene STARR-positive B cell enhancer ABC_E1234 Neighboring gene STARR-seq mESC enhancer starr_02843 Neighboring gene STARR-seq mESC enhancer starr_02844 Neighboring gene STARR-seq mESC enhancer starr_02845 Neighboring gene flavin containing monooxygenase 4 Neighboring gene VISTA enhancer mm713 Neighboring gene STARR-seq mESC enhancer starr_02846 Neighboring gene flavin containing monooxygenase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Representational difference analysis of cDNA of genes expressed in embryonic kidney. Wada J, et al. Kidney Int, 1997 May. PMID 9150484
    2. PRRC2B modulates oligodendrocyte progenitor cell development and myelination by stabilizing Sox2 mRNA. Zhang Y, et al. Cell Rep, 2024 Mar 26. PMID 38507412
    3. Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter. Piniella D, et al. Cell Mol Life Sci, 2021 Dec. PMID 34709416, Free PMC Article
    4. Integrative genomics positions MKRN1 as a novel ribonucleoprotein within the embryonic stem cell gene regulatory network. Cassar PA, et al. EMBO Rep, 2015 Oct. PMID 26265008, Free PMC Article
    5. Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA-splicing factors during adipogenesis. Mugabo Y, et al. J Biol Chem, 2018 May 4. PMID 29530978, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in hematopoietic progenitor cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in stress granule assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in stress granule assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic stress granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    protein PRRC2C
    Names
    BAT2 domain containing 1
    BAT2 domain-containing protein 1
    HLA-B-associated transcript 2-like 2
    proline-rich and coiled-coil-containing protein 2C
    protein BAT2-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081290.1 → NP_001074759.1  protein PRRC2C

      Status: PROVISIONAL

      Source sequence(s)
      AC118643, AC132867
      Consensus CDS
      CCDS35749.1
      UniProtKB/Swiss-Prot
      E9QKG5, Q05CS4, Q05DM5, Q3TKF3, Q3TLH4, Q3UXU5, Q4FZE4, Q66K03, Q6P3F4, Q80TK3, Q80YR0, Q8BMJ4, Q8C1K7, Q8CGH3
      Related
      ENSMUSP00000138433.2, ENSMUST00000182660.8
      Conserved Domains (2) summary
      pfam03153
      Location:2331 → 2534
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam07001
      Location:1 → 162
      BAT2_N; BAT2 N-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      162499354..162568125 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017320026.3 → XP_017175515.1  protein PRRC2C isoform X7

      Conserved Domains (2) summary
      PHA03247
      Location:1707 → 1979
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 162
      BAT2_N; BAT2 N-terminus

    2. XM_006496771.5 → XP_006496834.1  protein PRRC2C isoform X8

      Conserved Domains (2) summary
      PHA03247
      Location:1707 → 1979
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 162
      BAT2_N; BAT2 N-terminus

    3. XM_006496772.5 → XP_006496835.1  protein PRRC2C isoform X11

      Conserved Domains (2) summary
      PHA03247
      Location:1707 → 1979
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 162
      BAT2_N; BAT2 N-terminus

    4. XM_006496766.5 → XP_006496829.1  protein PRRC2C isoform X1

      Conserved Domains (2) summary
      PHA03247
      Location:1707 → 1979
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 162
      BAT2_N; BAT2 N-terminus

    5. XM_006496770.5 → XP_006496833.1  protein PRRC2C isoform X6

      Conserved Domains (2) summary
      PHA03247
      Location:1707 → 1979
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 162
      BAT2_N; BAT2 N-terminus

    6. XM_011238785.4 → XP_011237087.1  protein PRRC2C isoform X12

      UniProtKB/TrEMBL
      S4R294
      Related
      ENSMUSP00000138548.2, ENSMUST00000182149.8
      Conserved Domains (2) summary
      PHA03247
      Location:1707 → 1979
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 162
      BAT2_N; BAT2 N-terminus

    7. XM_011238784.4 → XP_011237086.1  protein PRRC2C isoform X9

      UniProtKB/Swiss-Prot
      Q3TLH4
      Conserved Domains (2) summary
      PHA03247
      Location:1707 → 1979
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 162
      BAT2_N; BAT2 N-terminus

    8. XM_006496769.5 → XP_006496832.1  protein PRRC2C isoform X5

      Conserved Domains (2) summary
      PHA03247
      Location:1700 → 1972
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 155
      BAT2_N; BAT2 N-terminus

    9. XM_006496767.5 → XP_006496830.1  protein PRRC2C isoform X2

      Conserved Domains (2) summary
      PHA03247
      Location:1705 → 1977
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 160
      BAT2_N; BAT2 N-terminus

    10. XM_011238788.4 → XP_011237090.1  protein PRRC2C isoform X10

      UniProtKB/TrEMBL
      S4R2J9
      Related
      ENSMUSP00000138674.2, ENSMUST00000182593.8
      Conserved Domains (2) summary
      PHA03247
      Location:1705 → 1977
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 160
      BAT2_N; BAT2 N-terminus

    11. XM_011238787.4 → XP_011237089.1  protein PRRC2C isoform X4

      UniProtKB/TrEMBL
      A0A0A0MQ79
      Related
      ENSMUSP00000028016.10, ENSMUST00000028016.16
      Conserved Domains (2) summary
      PHA03247
      Location:1705 → 1977
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 160
      BAT2_N; BAT2 N-terminus

    12. XM_006496768.5 → XP_006496831.1  protein PRRC2C isoform X3

      Conserved Domains (2) summary
      PHA03247
      Location:1702 → 1974
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 157
      BAT2_N; BAT2 N-terminus

    13. XM_011238786.4 → XP_011237088.1  protein PRRC2C isoform X13

      Conserved Domains (2) summary
      PHA03247
      Location:371 → 443
      PHA03247; large tegument protein UL36; Provisional
      pfam07001
      Location:1 → 162
      BAT2_N; BAT2 N-terminus

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_025603.1: Suppressed sequence

      Description
      NM_025603.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TLH4.3 GenPept UniProtKB/Swiss-Prot:Q3TLH4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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