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    Alox12 arachidonate 12-lipoxygenase [ Mus musculus (house mouse) ]

    Gene ID: 11684, updated on 9-Dec-2024

    Summary

    Official Symbol
    Alox12provided by MGI
    Official Full Name
    arachidonate 12-lipoxygenaseprovided by MGI
    Primary source
    MGI:MGI:87998
    See related
    Ensembl:ENSMUSG00000000320 AllianceGenome:MGI:87998
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P-12LO; Alox12p; 9930022G08Rik
    Summary
    Enables arachidonate 12(S)-lipoxygenase activity and linoleate 13S-lipoxygenase activity. Involved in establishment of skin barrier; fatty acid metabolic process; and negative regulation of platelet aggregation. Located in cytoplasm. Is expressed in alimentary system; liver; liver left lobe; liver right lobe; and lung vascular element. Orthologous to human ALOX12 (arachidonate 12-lipoxygenase, 12S type). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in genital fat pad adult (RPKM 9.9), spleen adult (RPKM 9.6) and 19 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Alox12 in Genome Data Viewer
    Location:
    11 B3; 11 42.99 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (70132283..70146206, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (70241457..70255380, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1832 Neighboring gene STARR-positive B cell enhancer ABC_E2998 Neighboring gene BPTF associated chromatin complex component 1 Neighboring gene ribonuclease, RNase K Neighboring gene predicted gene, 40191 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:70078889-70079072 Neighboring gene predicted gene, 32992 Neighboring gene predicted gene, 33048

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables arachidonate 12(S)-lipoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables arachidonate 12(S)-lipoxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables arachidonate 12(S)-lipoxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables arachidonate 12(S)-lipoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables arachidonate 12(S)-lipoxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables arachidonate 15-lipoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables arachidonate 15-lipoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables arachidonate 15-lipoxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables hepoxilin-epoxide hydrolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables linoleate 13S-lipoxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables linoleate 13S-lipoxygenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables linoleate 13S-lipoxygenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in arachidonate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in arachidonate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in arachidonate metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to lipid IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of skin barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fatty acid oxidation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fatty acid oxidation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in hepoxilin biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in hepoxilin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in leukotriene A4 metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in leukotriene A4 metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in linoleic acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in linoleic acid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipid oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipoxin A4 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipoxin A4 biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipoxin B4 biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in lipoxin B4 biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipoxygenase pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in lipoxygenase pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lipoxygenase pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lipoxygenase pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of muscle cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of muscle cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of platelet aggregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of blood vessel endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of blood vessel endothelial cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of endothelial tube morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of endothelial tube morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of mitochondrial depolarization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitochondrial depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of reactive oxygen species biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of reactive oxygen species biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in unsaturated fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in sarcolemma IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     
    located_in sarcolemma ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    polyunsaturated fatty acid lipoxygenase ALOX12
    Names
    12S-LOX
    12S-lipoxygenase
    arachidonate (12S)-lipoxygenase
    arachidonate (15S)-lipoxygenase
    arachidonate 12-lipoxygenase, 12S-type
    arachidonate 15-lipoxygenase,15S-type
    linoleate 13S-lipoxygenase
    lipoxin synthase 12-LO
    platelet-type lipoxygenase 12
    NP_001318047.1
    NP_031466.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001331118.1NP_001318047.1  polyunsaturated fatty acid lipoxygenase ALOX12 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
      Source sequence(s)
      AK036960, AK087724, AL669869
      UniProtKB/Swiss-Prot
      P39655
      Conserved Domains (1) summary
      pfam00305
      Location:58491
      Lipoxygenase; Lipoxygenase
    2. NM_007440.5NP_031466.2  polyunsaturated fatty acid lipoxygenase ALOX12 isoform 1

      See identical proteins and their annotated locations for NP_031466.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AK087724, AL669869
      Consensus CDS
      CCDS24942.1
      UniProtKB/Swiss-Prot
      P39655, Q8BHG4
      UniProtKB/TrEMBL
      A2CF85, Q3T9I9, Q3T9Y3
      Related
      ENSMUSP00000000329.3, ENSMUST00000000329.9
      Conserved Domains (2) summary
      cd01753
      Location:2111
      PLAT_LOX; PLAT domain of 12/15-lipoxygenase. As a unique subfamily of the mammalian lipoxygenases, they catalyze enzymatic lipid peroxidation in complex biological structures via direct dioxygenation of phospholipids and cholesterol esters of biomembranes and ...
      pfam00305
      Location:221654
      Lipoxygenase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      70132283..70146206 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001779865.2 RNA Sequence