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    Lrrc19 leucine rich repeat containing 19 [ Mus musculus (house mouse) ]

    Gene ID: 100061, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lrrc19provided by MGI
    Official Full Name
    leucine rich repeat containing 19provided by MGI
    Primary source
    MGI:MGI:2140219
    See related
    Ensembl:ENSMUSG00000049799 AllianceGenome:MGI:2140219
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9130022A01Rik
    Summary
    Enables signaling receptor activity. Involved in several processes, including host-mediated regulation of intestinal microbiota composition; positive regulation of canonical NF-kappaB signal transduction; and regulation of inflammatory response. Acts upstream of or within positive regulation of non-canonical NF-kappaB signal transduction and toll-like receptor signaling pathway. Located in plasma membrane. Orthologous to human LRRC19 (leucine rich repeat containing 19). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in kidney adult (RPKM 14.5), large intestine adult (RPKM 4.0) and 4 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lrrc19 in Genome Data Viewer
    Location:
    4 C5; 4 43.34 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (94523958..94538381, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (94635721..94650144, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_10788 Neighboring gene caspase activity and apoptosis inhibitor 1 Neighboring gene phospholipase A2, activating protein Neighboring gene STARR-positive B cell enhancer ABC_E3497 Neighboring gene H3.5 histone Neighboring gene intraflagellar transport 74 Neighboring gene STARR-seq mESC enhancer starr_10791 Neighboring gene microRNA 872 Neighboring gene predicted gene, 40205

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    leucine-rich repeat-containing protein 19

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356281.1NP_001343210.1  leucine-rich repeat-containing protein 19 precursor

      Status: VALIDATED

      Source sequence(s)
      AK033594, AK165421, AL732597
      Consensus CDS
      CCDS18360.1
      UniProtKB/Swiss-Prot
      B1AWG3, Q6P8J1, Q8BZT5
      Related
      ENSMUSP00000102718.2, ENSMUST00000107101.2
      Conserved Domains (4) summary
      smart00082
      Location:174211
      LRRCT; Leucine rich repeat C-terminal domain
      sd00031
      Location:7396
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:96155
      LRR_8; Leucine rich repeat
      pfam15176
      Location:251364
      LRR19-TM; Leucine-rich repeat family 19 TM domain
    2. NM_175305.5NP_780514.1  leucine-rich repeat-containing protein 19 precursor

      See identical proteins and their annotated locations for NP_780514.1

      Status: VALIDATED

      Source sequence(s)
      AK033594, AK165421
      Consensus CDS
      CCDS18360.1
      UniProtKB/Swiss-Prot
      B1AWG3, Q6P8J1, Q8BZT5
      Related
      ENSMUSP00000056094.3, ENSMUST00000053419.9
      Conserved Domains (4) summary
      smart00082
      Location:174211
      LRRCT; Leucine rich repeat C-terminal domain
      sd00031
      Location:7396
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:96155
      LRR_8; Leucine rich repeat
      pfam15176
      Location:251364
      LRR19-TM; Leucine-rich repeat family 19 TM domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      94523958..94538381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502614.4XP_006502677.1  leucine-rich repeat-containing protein 19 isoform X1

      See identical proteins and their annotated locations for XP_006502677.1

      UniProtKB/Swiss-Prot
      B1AWG3, Q6P8J1, Q8BZT5
      Conserved Domains (4) summary
      smart00082
      Location:174211
      LRRCT; Leucine rich repeat C-terminal domain
      sd00031
      Location:7396
      LRR_1; leucine-rich repeat [structural motif]
      pfam13855
      Location:96155
      LRR_8; Leucine rich repeat
      pfam15176
      Location:251364
      LRR19-TM; Leucine-rich repeat family 19 TM domain