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    Map2k6 mitogen-activated protein kinase kinase 6 [ Mus musculus (house mouse) ]

    Gene ID: 26399, updated on 27-Nov-2024

    Summary

    Official Symbol
    Map2k6provided by MGI
    Official Full Name
    mitogen-activated protein kinase kinase 6provided by MGI
    Primary source
    MGI:MGI:1346870
    See related
    Ensembl:ENSMUSG00000020623 AllianceGenome:MGI:1346870
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MEK6; MKK6; MAPKK6; Prkmk6; SAPKK3; MAPKK 6
    Summary
    Enables MAP kinase kinase activity. Involved in bone development; negative regulation of cold-induced thermogenesis; and osteoblast differentiation. Acts upstream of or within several processes, including MAPK cascade; cardiac muscle contraction; and positive regulation of MAP kinase activity. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Orthologous to human MAP2K6 (mitogen-activated protein kinase kinase 6). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 3.9), CNS E14 (RPKM 3.3) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Map2k6 in Genome Data Viewer
    Location:
    11 E1- E2; 11 73.6 cM
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (110289928..110416348)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (110399102..110525522)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr11:110133108-110133408 Neighboring gene STARR-seq mESC enhancer starr_31036 Neighboring gene ATP-binding cassette, sub-family A member 5 Neighboring gene predicted gene, 39445 Neighboring gene STARR-seq mESC enhancer starr_31038 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:110260179-110260474 Neighboring gene STARR-positive B cell enhancer ABC_E8466 Neighboring gene STARR-positive B cell enhancer ABC_E8467 Neighboring gene STARR-positive B cell enhancer mm9_chr11:110309701-110310002 Neighboring gene STARR-positive B cell enhancer mm9_chr11:110344566-110344867 Neighboring gene predicted gene, 39446 Neighboring gene predicted gene, 30009 Neighboring gene predicted gene 11682

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables JUN kinase kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables MAP kinase kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables MAP kinase kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables MAP kinase kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables MAP kinase kinase activity TAS
    Traceable Author Statement
    more info
     
    enables histone H2AXY142 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3Y41 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in JNK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within MAPK cascade IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bone development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cardiac muscle contraction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to sorbitol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ovulation cycle process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in p38MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in p38MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of MAP kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of prostaglandin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of prostaglandin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to ischemia IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stress-activated MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stress-activated MAPK cascade ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in stress-activated protein kinase signaling cascade ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dual specificity mitogen-activated protein kinase kinase 6
    Names
    MAP kinase kinase 6
    MAPK/ERK kinase 6
    protein kinase, mitogen activated, kinase 6
    NP_001343274.1
    NP_001343275.1
    NP_001343276.1
    NP_001343281.1
    NP_001343282.1
    NP_036073.1
    XP_011247336.2
    XP_011247337.1
    XP_036012601.1
    XP_036012602.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356345.1NP_001343274.1  dual specificity mitogen-activated protein kinase kinase 6 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) includes a different 3' exon structure, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AK086722, AK162671, BY280286
      Consensus CDS
      CCDS88279.1
      UniProtKB/TrEMBL
      A2AGS2, Q8C371
      Related
      ENSMUSP00000097831.2, ENSMUST00000100260.2
      Conserved Domains (1) summary
      cd06617
      Location:51293
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    2. NM_001356346.1NP_001343275.1  dual specificity mitogen-activated protein kinase kinase 6 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and the 5' CDS and uses a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variants 3, 4 and 5 encode the same isoform (3).
      Source sequence(s)
      AI429449, AK162671, BY284275
      Conserved Domains (1) summary
      cd06617
      Location:1264
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    3. NM_001356347.1NP_001343276.1  dual specificity mitogen-activated protein kinase kinase 6 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and the 5' CDS and uses a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variants 3, 4 and 5 encode the same isoform (3).
      Source sequence(s)
      AA389344, AI429449, AK162671, AL691461, BY284275
      Conserved Domains (1) summary
      cd06617
      Location:1264
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    4. NM_001356352.1NP_001343281.1  dual specificity mitogen-activated protein kinase kinase 6 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and the 5' CDS and uses a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variants 3, 4 and 5 encode the same isoform (3).
      Source sequence(s)
      AI429449, AK140289, BY280286
      Conserved Domains (1) summary
      cd06617
      Location:1264
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    5. NM_001356353.1NP_001343282.1  dual specificity mitogen-activated protein kinase kinase 6 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and the 5' CDS and uses a downstream start codon, compared to variant 1. It encodes isoform 4, which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AI429449, AK140289, AK141708, BB202796, BE859531, BU695367, BY280286
      UniProtKB/TrEMBL
      Q60521
      Related
      ENSMUST00000146084.8
      Conserved Domains (1) summary
      cl21453
      Location:1236
      PKc_like; Protein Kinases, catalytic domain
    6. NM_011943.3NP_036073.1  dual specificity mitogen-activated protein kinase kinase 6 isoform 1

      See identical proteins and their annotated locations for NP_036073.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI429449, AK043482, BY280286
      Consensus CDS
      CCDS25592.1
      UniProtKB/Swiss-Prot
      P70236
      UniProtKB/TrEMBL
      Q543Z5, Q8BP44
      Related
      ENSMUSP00000020949.6, ENSMUST00000020949.12
      Conserved Domains (1) summary
      cd06617
      Location:51333
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      110289928..110416348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011249034.4XP_011247336.2  dual specificity mitogen-activated protein kinase kinase 6 isoform X1

      Conserved Domains (1) summary
      cd06617
      Location:1264
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    2. XM_036156708.1XP_036012601.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X2

      UniProtKB/TrEMBL
      Q8BP44
      Conserved Domains (1) summary
      cd06617
      Location:64346
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    3. XM_011249035.3XP_011247337.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X1

      See identical proteins and their annotated locations for XP_011247337.1

      Conserved Domains (1) summary
      cd06617
      Location:1264
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6
    4. XM_036156709.1XP_036012602.1  dual specificity mitogen-activated protein kinase kinase 6 isoform X1

      Conserved Domains (1) summary
      cd06617
      Location:1264
      PKc_MKK3_6; Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6