Slc24a3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc24a3provided by MGI
Official Full Name: solute carrier family 24 (sodium/potassium/calcium exchanger), member 3provided by MGI
Primary source: MGI:MGI:2137513
See related: Ensembl:ENSMUSG00000063873 AllianceGenome:MGI:2137513
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NCKX3
Summary: Enables calcium, potassium:sodium antiporter activity. Acts upstream of or within bone mineralization; intracellular calcium ion homeostasis; and regulation of gene expression. Located in cell periphery. Is expressed in several structures, including alimentary system; central nervous system; dorsal root ganglion; eye; and musculature. Orthologous to human SLC24A3 (solute carrier family 24 member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bladder adult (RPKM 24.5), subcutaneous fat pad adult (RPKM 18.0) and 18 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 G1; 2 71.08 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (145009695..145484086)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (145167775..145642166)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Potassium-dependent sodium/calcium exchanger 3 (Nckx3) depletion leads to abnormal motor function and social behavior in mice.
Title: Potassium-dependent sodium/calcium exchanger 3 (Nckx3) depletion leads to abnormal motor function and social behavior in mice.
Loss of Nckx3 Exacerbates Experimental DSS-Induced Colitis in Mice through p53/NF-kappaB Pathway.
Title: Loss of Nckx3 Exacerbates Experimental DSS-Induced Colitis in Mice through p53/NF-κB Pathway.
NCKX3 may play a role in regulating calcium homeostasis.
Title: NCKX3 was compensated by calcium transporting genes and bone resorption in a NCKX3 KO mouse model.
Suggest that a high level of renal NCKX3 expression maintain in distal convoluted tubules may play a role in active calcium transport in the kidneys of female mice.
Title: K+-dependent Na+/Ca2+ exchanger 3 is involved in renal active calcium transport and is differentially expressed in the mouse kidney.
The results of the present study indicate that NCKX3 is abundantly expressed in the uterus and that its expression is regulated by the steroid hormones E2 and P4.
Title: Sodium/potassium/calcium exchanger 3 is regulated by the steroid hormones estrogen and progesterone in the uterus of mice during the estrous cycle.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

General gene information

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Markers

RH126144 (e-PCR)
- UniSTS:162856

27.MMHAP59FLA6.seq (e-PCR)
- UniSTS:123789

D2Mit109 (e-PCR), detects polymorphism
- UniSTS:128967

Slc24a3 (e-PCR), detects polymorphism
- UniSTS:547322

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium, potassium:sodium antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium, potassium:sodium antiporter activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium, potassium:sodium antiporter activity	ISO Inferred from Sequence Orthology more info
enables calcium, potassium:sodium antiporter activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone mineralization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular calcium ion homeostasis	TAS Traceable Author Statement more info	PubMed
involved_in monoatomic cation transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in potassium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cell periphery	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed

General protein information

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Preferred Names: sodium/potassium/calcium exchanger 3

Names: Na(+)/K(+)/Ca(2+)-exchange protein 3; solute carrier family 24 member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001356497.1 → NP_001343426.1 sodium/potassium/calcium exchanger 3 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AL772192, AL808117, AL824715, AL831783

Consensus CDS

CCDS89560.1

UniProtKB/Swiss-Prot

B1AWL7, Q99JR2, Q99PD7, Q99PD8

Related

ENSMUSP00000105634.2, ENSMUST00000110007.8

Conserved Domains (1) summary

cl27511
Location:89 → 631

Na_Ca_ex; Sodium/calcium exchanger protein
NM_053195.3 → NP_444425.1 sodium/potassium/calcium exchanger 3 isoform 2

See identical proteins and their annotated locations for NP_444425.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL808117, AL824715, AL831783

Consensus CDS

CCDS38256.1

UniProtKB/TrEMBL

Q8VD29

Related

ENSMUSP00000079897.4, ENSMUST00000081121.4

Conserved Domains (2) summary

TIGR00367
Location:61 → 557

TIGR00367; K+-dependent Na+/Ca+ exchanger related-protein

pfam01699
Location:62 → 204

Na_Ca_ex; Sodium/calcium exchanger protein