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    MTHFR1 methylenetetrahydrofolate reductase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825167, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MTHFR1
    Official Full Name
    methylenetetrahydrofolate reductase 1
    Primary source
    TAIR:AT3G59970
    Locus tag
    AT3G59970
    See related
    Araport:AT3G59970
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    methylenetetrahydrofolate reductase 1
    Summary
    methylenetetrahydrofolate reductase MTHFR1 mRNA, complete
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    Genomic context

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    See MTHFR1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    10
    Sequence:
    Chromosome: 3; NC_003074.8 (22151164..22154483)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Peptidase family C54 protein Neighboring gene ncRNA Neighboring gene histone-lysine N-methyltransferase ASHH4 Neighboring gene ncRNA Neighboring gene Nucleic acid-binding, OB-fold-like protein Neighboring gene methionine aminopeptidase 2B Neighboring gene QWRF motif protein (DUF566)

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
    2. A Pan-plant Protein Complex Map Reveals Deep Conservation and Novel Assemblies. McWhite CD, et al. Cell, 2020 Apr 16. PMID 32191846, Free PMC Article
    3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_115860.4
    NM_180392.1
    NM_180393.1

    Gene Ontology Provided by TAIR

    Process Evidence Code Pubs
    involved_in methionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    methylenetetrahydrofolate reductase 1
    NP_191556.1
    • methylenetetrahydrofolate reductase 1 (MTHFR1); FUNCTIONS IN: methylenetetrahydrofolate reductase (NADPH) activity; INVOLVED IN: oxidation reduction, methionine metabolic process; EXPRESSED IN: fruit, guard cell, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Methylenetetrahydrofolate reductase (InterPro:IPR003171), Eukaryotic-type methylenetetrahydrofolate reductase (InterPro:IPR004621); BEST Arabidopsis thaliana protein match is: methylenetetrahydrofolate reductase 2 (TAIR:AT2G44160.1); Has 4753 Blast hits to 4742 proteins in 1927 species: Archae - 14; Bacteria - 3601; Metazoa - 134; Fungi - 280; Plants - 73; Viruses - 0; Other Eukaryotes - 651 (source: NCBI BLink).
    NP_850723.1
    • methylenetetrahydrofolate reductase 1 (MTHFR1); FUNCTIONS IN: methylenetetrahydrofolate reductase (NADPH) activity; INVOLVED IN: oxidation reduction, methionine metabolic process; EXPRESSED IN: fruit, guard cell, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Methylenetetrahydrofolate reductase (InterPro:IPR003171), Eukaryotic-type methylenetetrahydrofolate reductase (InterPro:IPR004621); BEST Arabidopsis thaliana protein match is: methylenetetrahydrofolate reductase 2 (TAIR:AT2G44160.1); Has 4714 Blast hits to 4712 proteins in 1919 species: Archae - 14; Bacteria - 3588; Metazoa - 129; Fungi - 271; Plants - 66; Viruses - 0; Other Eukaryotes - 646 (source: NCBI BLink).
    NP_850724.1
    • methylenetetrahydrofolate reductase 1 (MTHFR1); FUNCTIONS IN: methylenetetrahydrofolate reductase (NADPH) activity; INVOLVED IN: oxidation reduction, methionine metabolic process; EXPRESSED IN: fruit, guard cell, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Methylenetetrahydrofolate reductase (InterPro:IPR003171), Eukaryotic-type methylenetetrahydrofolate reductase (InterPro:IPR004621); BEST Arabidopsis thaliana protein match is: methylenetetrahydrofolate reductase 2 (TAIR:AT2G44160.1); Has 4714 Blast hits to 4712 proteins in 1919 species: Archae - 14; Bacteria - 3588; Metazoa - 129; Fungi - 271; Plants - 66; Viruses - 0; Other Eukaryotes - 646 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      22151164..22154483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115860.4 → NP_191556.1  methylenetetrahydrofolate reductase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191556.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q3EAG9, Q9SE60
      UniProtKB/TrEMBL
      A0A178VC94, A0A5S9XP49
      Conserved Domains (1) summary
      PLN02540
      Location:18 → 582
      PLN02540; methylenetetrahydrofolate reductase

    2. NM_180392.1 → NP_850723.1  methylenetetrahydrofolate reductase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850723.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SE60
      Conserved Domains (1) summary
      cl00246
      Location:18 → 397
      MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...

    3. NM_180393.1 → NP_850724.1  methylenetetrahydrofolate reductase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850724.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4JAK1
      Conserved Domains (1) summary
      cl00246
      Location:18 → 397
      MTHFR; Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SE60.1

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