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    cgt-3 Ceramide glucosyltransferase 3 [ Caenorhabditis elegans ]

    Gene ID: 174001, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cgt-3
    Official Full Name
    Ceramide glucosyltransferase 3
    Primary source
    WormBase:WBGene00019127
    Locus tag
    CELE_F59G1.1
    See related
    AllianceGenome:WB:WBGene00019127
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ceramide glucosyltransferase activity. Involved in several processes, including glucosylceramide biosynthetic process; regulation of mesodermal cell fate specification; and regulation of protein localization to basolateral plasma membrane. Located in plasma membrane. Is expressed in several structures, including germ line; head mesodermal cell; hypodermis; pharynx; and rectum. Orthologous to human UGCG (UDP-glucose ceramide glucosyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cgt-3 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    7
    Sequence:
    Chromosome: II; NC_003280.10 (5911324..5916910)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Vacuolar protein sorting-associated protein 35 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Frataxin, mitochondrial Neighboring gene Tyrosine-protein phosphatase non-receptor type ptp-2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The impact of C. elegans ceramide glucosyltransferase enzymes on the beneficial effects of B. subtilis lifespan. Arvin CL, et al. MicroPubl Biol, 2023. PMID 37090153, Free PMC Article
    2. Glucosylceramide synthase and glycosphingolipid synthesis. Ichikawa S, et al. Trends Cell Biol, 1998 May. PMID 9695839
    3. Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells. Marza E, et al. J Cell Sci, 2009 Mar 15. PMID 19240113, Free PMC Article
    4. Ceramide glucosyltransferase of the nematode Caenorhabditis elegans is involved in oocyte formation and in early embryonic cell division. Nomura KH, et al. Glycobiology, 2011 Jun. PMID 21325339
    5. Targeted lipidomics reveals a novel role for glucosylceramides in glucose response. Xatse MA, et al. J Lipid Res, 2023 Jul. PMID 37245562, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Animals lacking CGT do not synthesize glycosphingolipids, arrest growth at the first larval stage, and display defects in a subset of cells in their digestive tract.
      Title: Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ceramide glucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ceramide glucosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in glucosylceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glucosylceramide biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nematode larval development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of mesodermal cell fate specification IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of mesodermal cell fate specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein localization to basolateral plasma membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ceramide glucosyltransferase 3
    NP_001367789.1
    • Confirmed by transcript evidence
    NP_495181.2
    • Confirmed by transcript evidence
    NP_495182.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5911324..5916910
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062780.6 → NP_495181.2  Ceramide glucosyltransferase 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495181.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q21054
      Conserved Domains (2) summary
      TIGR03472
      Location:119 → 467
      HpnI; hopanoid biosynthesis associated glycosyl transferase protein HpnI
      cd02520
      Location:126 → 357
      Glucosylceramide_synthase; Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis

    2. NM_062781.6 → NP_495182.2  Ceramide glucosyltransferase 3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495182.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      G5EET1, G5EGR9, Q21054, Q8T3D8
      Conserved Domains (2) summary
      TIGR03472
      Location:108 → 456
      HpnI; hopanoid biosynthesis associated glycosyl transferase protein HpnI
      cd02520
      Location:115 → 346
      Glucosylceramide_synthase; Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis

    3. NM_001381440.1 → NP_001367789.1  Ceramide glucosyltransferase 3 [Caenorhabditis elegans]

      Status: REVIEWED

      Conserved Domains (1) summary
      cd02520
      Location:48 → 279
      Glucosylceramide_synthase; Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis

    RNA

    1. NR_151564.1 RNA Sequence

      Status: REVIEWED

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q21054.2

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