Proz protein Z, vitamin K-dependent plasma glycoprotein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Prozprovided by MGI
Official Full Name: protein Z, vitamin K-dependent plasma glycoproteinprovided by MGI
Primary source: MGI:MGI:1860488
See related: Ensembl:ENSMUSG00000031445 AllianceGenome:MGI:1860488
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1300015B06Rik
Summary: Predicted to enable serine-type endopeptidase activity. Acts upstream of or within blood coagulation. Located in extracellular region. Is expressed in liver and plasma. Human ortholog(s) of this gene implicated in Behcet's disease and brain ischemia. Orthologous to human PROZ (protein Z, vitamin K dependent plasma glycoprotein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 113.6), liver E18 (RPKM 53.9) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 A1.1; 8 5.73 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (13110583..13126026)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (13060584..13076026)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PZ contributes to a reduced neointima formation after vascular injury, underlining the modulatory role of the coagulation cascade in vascular homeostasis.
Title: Protein Z-deficiency is associated with enhanced neointima formation and inflammatory response after vascular injury in mice.
Letter: protein Z is not a typical acute phase reactant.
Title: Protein Z, protein Z-dependent protease inhibitor (serpinA10), and the acute-phase response.
PZ and ZPI deficiency would be associated with a modest thrombotic risk with ZPI deficiency producing a more severe phenotype.
Title: Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	TAS Traceable Author Statement more info	PubMed
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in blood coagulation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within blood coagulation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within blood coagulation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: vitamin K-dependent protein Z

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357219.1 → NP_001344148.1 vitamin K-dependent protein Z isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AC127308

Consensus CDS

CCDS90373.1

UniProtKB/TrEMBL

Q8CI01

Related

ENSMUSP00000147733.2, ENSMUST00000211363.2

Conserved Domains (4) summary

smart00069
Location:23 → 85

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:95 → 122

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam14670
Location:136 → 165

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl27237
Location:192 → 239

Trypsin; Trypsin
NM_001357220.1 → NP_001344149.1 vitamin K-dependent protein Z isoform 3

Status: VALIDATED

Source sequence(s)

AC127308

UniProtKB/TrEMBL

Q05CL2

Conserved Domains (3) summary

cd00054
Location:25 → 52

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00089
Location:122 → 270

Trypsin; Trypsin

pfam14670
Location:66 → 95

FXa_inhibition; Coagulation Factor Xa inhibitory site
NM_025834.4 → NP_080110.1 vitamin K-dependent protein Z isoform 1 precursor

See identical proteins and their annotated locations for NP_080110.1

Status: VALIDATED

Source sequence(s)

AC127308, AK005011, AK008819

Consensus CDS

CCDS22105.1

UniProtKB/Swiss-Prot

Q9CQW3

Related

ENSMUSP00000033822.3, ENSMUST00000033822.4

Conserved Domains (5) summary

smart00069
Location:23 → 85

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:95 → 122

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00089
Location:192 → 340

Trypsin; Trypsin

pfam14670
Location:136 → 165

FXa_inhibition; Coagulation Factor Xa inhibitory site

cl21584
Location:192 → 397

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

13110583..13126026

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006508859.5 → XP_006508922.1 vitamin K-dependent protein Z isoform X2

Conserved Domains (3) summary

smart00069
Location:23 → 85

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:95 → 122

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam14670
Location:136 → 165

FXa_inhibition; Coagulation Factor Xa inhibitory site
XM_006508858.4 → XP_006508921.1 vitamin K-dependent protein Z isoform X1

Conserved Domains (3) summary

smart00069
Location:23 → 85

GLA; Domain containing Gla (gamma-carboxyglutamate) residues

cd00054
Location:95 → 122

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam14670
Location:136 → 165

FXa_inhibition; Coagulation Factor Xa inhibitory site