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    Spink6 serine peptidase inhibitor, Kazal type 6 [ Mus musculus (house mouse) ]

    Gene ID: 433180, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Spink6provided by MGI
    Official Full Name
    serine peptidase inhibitor, Kazal type 6provided by MGI
    Primary source
    MGI:MGI:3648654
    See related
    Ensembl:ENSMUSG00000055095 AllianceGenome:MGI:3648654
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EG433180
    Summary
    Enables serine-type endopeptidase inhibitor activity. Acts upstream of or within negative regulation of serine-type endopeptidase activity. Located in extracellular region. Orthologous to human SPINK6 (serine peptidase inhibitor Kazal type 6). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human all
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    Genomic context

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    See Spink6 in Genome Data Viewer
    Location:
    18 B3; 18 23.74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (44204460..44216678)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (44071393..44083611)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene serine peptidase inhibitor, Kazal type 14 Neighboring gene high mobility group box 2 pseudogene Neighboring gene serine peptidase inhibitor, Kazal type 12 Neighboring gene MARCO like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of Spink6 in mouse skin: the conserved inhibitor of kallikrein-related peptidases is reduced by barrier injury. Fischer J, et al. J Invest Dermatol, 2014 May. PMID 24352040
    2. A mouse knockout library for secreted and transmembrane proteins. Tang T, et al. Nat Biotechnol, 2010 Jul. PMID 20562862
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our study indicates that Spink6 is a potent inhibitor of kallikrein related peptidases and involved in skin barrier function.
      Title: Characterization of Spink6 in mouse skin: the conserved inhibitor of kallikrein-related peptidases is reduced by barrier injury.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables serine-type endopeptidase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables serine-type endopeptidase inhibitor activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of serine-type endopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine protease inhibitor Kazal-type 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013797.2 → NP_001013819.1  serine protease inhibitor Kazal-type 6 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001013819.1

      Status: VALIDATED

      Source sequence(s)
      AK028032, BB609825
      Consensus CDS
      CCDS29224.1
      UniProtKB/Swiss-Prot
      Q8BT20
      Related
      ENSMUSP00000069247.3, ENSMUST00000068473.4
      Conserved Domains (1) summary
      pfam00050
      Location:61 → 105
      Kazal_1; Kazal-type serine protease inhibitor domain

    2. NM_001357563.1 → NP_001344492.1  serine protease inhibitor Kazal-type 6 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AK028032, BB609825, BC147471
      Consensus CDS
      CCDS89231.1
      UniProtKB/TrEMBL
      B7ZWD4, B9EJQ7
      Related
      ENSMUSP00000157648.2, ENSMUST00000236634.2
      Conserved Domains (1) summary
      pfam00050
      Location:36 → 80
      Kazal_1; Kazal-type serine protease inhibitor domain

    3. NM_001357564.1 → NP_001344493.1  serine protease inhibitor Kazal-type 6 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124181, BB609825
      Consensus CDS
      CCDS89232.1
      UniProtKB/TrEMBL
      A0A494BB62
      Related
      ENSMUSP00000158333.2, ENSMUST00000235436.2
      Conserved Domains (1) summary
      pfam00050
      Location:50 → 94
      Kazal_1; Kazal-type serine protease inhibitor domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      44204460..44216678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BT20.1 GenPept UniProtKB/Swiss-Prot:Q8BT20

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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