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    Edf1 endothelial differentiation-related factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 59022, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Edf1provided by MGI
    Official Full Name
    endothelial differentiation-related factor 1provided by MGI
    Primary source
    MGI:MGI:1891227
    See related
    Ensembl:ENSMUSG00000015092 AllianceGenome:MGI:1891227
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MBF1; 0610008L11Rik
    Summary
    Predicted to enable TFIID-class transcription factor complex binding activity and transcription coactivator activity. Predicted to be involved in cell differentiation and positive regulation of DNA-templated transcription. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina; and spleen. Orthologous to human EDF1 (endothelial differentiation related factor 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in small intestine adult (RPKM 103.6), duodenum adult (RPKM 81.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Edf1 in Genome Data Viewer
    Location:
    2 A3; 2 17.39 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25447838..25452096)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25557824..25562084)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene TNF receptor-associated factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E273 Neighboring gene cytochrome c oxidase subunit 7A2, mitochondrial pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:25404685-25404887 Neighboring gene STARR-positive B cell enhancer ABC_E11127 Neighboring gene predicted gene, 35476 Neighboring gene MAM domain containing 4 Neighboring gene STARR-positive B cell enhancer ABC_E1582 Neighboring gene phosphohistidine phosphatase 1 Neighboring gene apical junction component 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. EDF-1 downregulates the CaM/Cn/NFAT signaling pathway during adipogenesis. López-Victorio CJ, et al. Biochem Biophys Res Commun, 2013 Mar 1. PMID 23376715
    2. Transcriptional coactivator EDF-1 is required for PPARgamma-stimulated adipogenesis. Leidi M, et al. Cell Mol Life Sci, 2009 Aug. PMID 19554257, Free PMC Article
    3. Cloning and characterization of murine EDF-1. De Benedictis L, et al. Gene, 2001 Sep 19. PMID 11587857
    4. Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains. Inoue S, et al. Biochem Biophys Res Commun, 2000 Feb 16. PMID 10679242
    5. Genetic loci that control vascular endothelial growth factor-induced angiogenesis. Rogers MS, et al. FASEB J, 2003 Nov. PMID 12958152

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. these results showed that EDF-1 inactivates the calmodulin/calcineurin/NFAT pathway via sequestration of calmodulin, during early adipogenesis.
      Title: EDF-1 downregulates the CaM/Cn/NFAT signaling pathway during adipogenesis.
    2. EDF-1 is required for PPARgamma transcriptional activation during preadipocyte differentiation.
      Title: Transcriptional coactivator EDF-1 is required for PPARgamma-stimulated adipogenesis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables TFIID-class transcription factor complex binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables TFIID-class transcription factor complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    endothelial differentiation-related factor 1
    Names
    hypothetical protein 1-9
    multiprotein-bridging factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021519.2 → NP_067494.1  endothelial differentiation-related factor 1

      See identical proteins and their annotated locations for NP_067494.1

      Status: VALIDATED

      Source sequence(s)
      AB030185, BB856073, CF740336
      Consensus CDS
      CCDS15780.1
      UniProtKB/Swiss-Prot
      Q99NE6, Q9JMG1
      Related
      ENSMUSP00000015236.4, ENSMUST00000015236.4
      Conserved Domains (2) summary
      cl26727
      Location:48 → 142
      aMBF1; Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]
      pfam08523
      Location:5 → 71
      MBF1; Multiprotein bridging factor 1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25447838..25452096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251920.2 → XP_030107780.1  endothelial differentiation-related factor 1 isoform X1

      Conserved Domains (1) summary
      pfam08523
      Location:4 → 72
      MBF1; Multiprotein bridging factor 1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JMG1.1 GenPept UniProtKB/Swiss-Prot:Q9JMG1

    Gene LinkOut

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