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    Nutf2 nuclear transport factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 68051, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nutf2provided by MGI
    Official Full Name
    nuclear transport factor 2provided by MGI
    Primary source
    MGI:MGI:1915301
    See related
    Ensembl:ENSMUSG00000008450 AllianceGenome:MGI:1915301
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ntf2; Ntf3; PP15; 2700067I02Rik
    Summary
    Predicted to enable identical protein binding activity; nuclear import signal receptor activity; and small GTPase binding activity. Acts upstream of or within protein import into nucleus. Predicted to be located in cytosol; nuclear outer membrane; and nucleoplasm. Predicted to be part of nuclear pore central transport channel. Is expressed in several structures, including alimentary system; central nervous system; integumental system; salivary gland primordium; and sensory organ. Human ortholog(s) of this gene implicated in diabetic retinopathy. Orthologous to human NUTF2 (nuclear transport factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 42.8), CNS E14 (RPKM 34.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nutf2 in Genome Data Viewer
    Location:
    8 D3; 8 53.05 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (106587165..106607034)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105860533..105880402)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene translin-associated factor X (Tsnax) interacting protein 1 Neighboring gene centromere protein T Neighboring gene STARR-positive B cell enhancer ABC_E2875 Neighboring gene STARR-positive B cell enhancer ABC_E3799 Neighboring gene THAP domain containing 11 Neighboring gene STARR-seq mESC enhancer starr_22544 Neighboring gene STARR-seq mESC enhancer starr_22545 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:108404648-108404831 Neighboring gene enhancer of mRNA decapping 4 Neighboring gene neuritin 1-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An ATP-dependent activity that releases RanGDP from NTF2. Yamada M, et al. J Biol Chem, 2004 Aug 27. PMID 15155737
    2. Interaction between NTF2 and xFxFG-containing nucleoporins is required to mediate nuclear import of RanGDP. Bayliss R, et al. J Mol Biol, 1999 Oct 29. PMID 10543952
    3. Importin alpha/beta mediates nuclear transport of a mammalian circadian clock component, mCRY2, together with mPER2, through a bipartite nuclear localization signal. Sakakida Y, et al. J Biol Chem, 2005 Apr 8. PMID 15689618
    4. Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Keegan CE, et al. Hum Mol Genet, 2005 Jan 1. PMID 15537664
    5. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102015

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear import signal receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear import signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear import signal receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleocytoplasmic carrier activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to nuclear pore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein localization to nuclear pore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear outer membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear pore central transport channel IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear pore central transport channel ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nuclear transport factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357229.1 → NP_001344158.1  nuclear transport factor 2

      Status: VALIDATED

      Source sequence(s)
      AC116569, AC159265
      Consensus CDS
      CCDS22617.1
      UniProtKB/Swiss-Prot
      P61971, Q3TI35
      UniProtKB/TrEMBL
      Q3U8H8
      Conserved Domains (1) summary
      cd00780
      Location:7 → 122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    2. NM_001357230.1 → NP_001344159.1  nuclear transport factor 2

      Status: VALIDATED

      Source sequence(s)
      AC116569, AC159265
      Consensus CDS
      CCDS22617.1
      UniProtKB/Swiss-Prot
      P61971, Q3TI35
      UniProtKB/TrEMBL
      Q3U8H8
      Related
      ENSMUSP00000148713.2, ENSMUST00000212042.2
      Conserved Domains (1) summary
      cd00780
      Location:7 → 122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    3. NM_026532.4 → NP_080808.1  nuclear transport factor 2

      See identical proteins and their annotated locations for NP_080808.1

      Status: VALIDATED

      Source sequence(s)
      AK002461, BC086773, CJ059612
      Consensus CDS
      CCDS22617.1
      UniProtKB/Swiss-Prot
      P61971, Q3TI35
      UniProtKB/TrEMBL
      Q3U8H8
      Related
      ENSMUSP00000008594.8, ENSMUST00000008594.9
      Conserved Domains (1) summary
      cd00780
      Location:7 → 122
      NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      106587165..106607034
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P61971.1 GenPept UniProtKB/Swiss-Prot:P61971

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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