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    Aldoa aldolase A, fructose-bisphosphate [ Mus musculus (house mouse) ]

    Gene ID: 11674, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Aldoaprovided by MGI
    Official Full Name
    aldolase A, fructose-bisphosphateprovided by MGI
    Primary source
    MGI:MGI:87994
    See related
    Ensembl:ENSMUSG00000030695 AllianceGenome:MGI:87994
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aldo1; Aldo-1
    Summary
    Enables fructose-bisphosphate aldolase activity and protease binding activity. Involved in canonical glycolysis and positive regulation of cell migration. Located in Z disc; plasma membrane; and sperm fibrous sheath. Part of protein-containing complex. Is active in cytosol. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human ALDOA (aldolase, fructose-bisphosphate A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in mammary gland adult (RPKM 794.0), subcutaneous fat pad adult (RPKM 494.9) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Aldoa in Genome Data Viewer
    Location:
    7 F3; 7 69.25 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126394406..126399537, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126795234..126800994, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene T-box 6 Neighboring gene protein phosphatase 4, catalytic subunit Neighboring gene STARR-positive B cell enhancer ABC_E6603 Neighboring gene predicted gene, 57854 Neighboring gene STARR-positive B cell enhancer ABC_E10476 Neighboring gene TLC domain containing 3B Neighboring gene RIKEN cDNA 4930451I11 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Negative regulation of the mouse aldolase A gene. A cell cycle-dependent DNA binding activity functions as a silencer of gene transcription. Lupo A, et al. J Biol Chem, 1997 Dec 12. PMID 9395505
    2. Sequence of a mouse brain aldolase A cDNA. Mestek A, et al. Nucleic Acids Res, 1987 Dec 23. PMID 3697100, Free PMC Article
    3. The proximal promoter of the aldolase A gene remains active during myogenesis in vitro and muscle development in vivo. Colbert MC, et al. Dev Biol, 1992 Jan. PMID 1728594
    4. Nonconservative utilization of aldolase A alternative promoters. Stauffer JK, et al. J Biol Chem, 1990 Jul 15. PMID 2365699
    5. Integrating Proteomics and Enzyme Kinetics Reveals Tissue-Specific Types of the Glycolytic and Gluconeogenic Pathways. Wiśniewski JR, et al. J Proteome Res, 2015 Aug 7. PMID 26080680

    See all (101) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development.
      Title: Beyond Glycolysis: Aldolase A Is a Novel Effector in Reelin-Mediated Dendritic Development.
    2. The results presented here point to ALDA as a factor involved in the regulation of cells proliferation.
      Title: Nuclear localization of aldolase A correlates with cell proliferation.
    3. Aldolase inhibits WASP/Arp2/3-dependent actin polymerization in vitro
      Title: Aldolase sequesters WASP and affects WASP/Arp2/3-stimulated actin dynamics.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107164, AC124505.11

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cytoskeletal protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fructose binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fructose-bisphosphate aldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose-bisphosphate aldolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fructose-bisphosphate aldolase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables fructose-bisphosphate aldolase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables fructose-bisphosphate aldolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables fructose-bisphosphate aldolase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in binding of sperm to zona pellucida ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in canonical glycolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in fructose 1,6-bisphosphate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in fructose metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycolytic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within glycolytic process through fructose-6-phosphate IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in methylglyoxal biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in muscle cell cellular homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell shape ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in striated muscle contraction ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in M band IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Z disc IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space HDA PubMed 
    located_in heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in myelin sheath HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm fibrous sheath IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in sperm head ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    fructose-bisphosphate aldolase A
    Names
    muscle-type aldolase
    NP_001170778.1
    NP_001170779.1
    NP_001398830.1
    NP_001398831.1
    NP_001398832.1
    NP_001398833.1
    NP_031464.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177307.2 → NP_001170778.1  fructose-bisphosphate aldolase A isoform 1 precursor

      See identical proteins and their annotated locations for NP_001170778.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longer protein (isoform 1).
      Source sequence(s)
      AC124505
      Consensus CDS
      CCDS52399.1
      UniProtKB/TrEMBL
      A6ZI44, Q6NY00
      Related
      ENSMUSP00000084846.5, ENSMUST00000087566.11
      Conserved Domains (1) summary
      pfam00274
      Location:69 → 418
      Glycolytic; Fructose-bisphosphate aldolase class-I

    2. NM_001177308.2 → NP_001170779.1  fructose-bisphosphate aldolase A isoform 2

      See identical proteins and their annotated locations for NP_001170779.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in its 5' end and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2 and 3 encode the same protein.
      Source sequence(s)
      AC124505
      Consensus CDS
      CCDS21845.1
      UniProtKB/Swiss-Prot
      P05064
      UniProtKB/TrEMBL
      Q5FWB7, Q6NY00
      Related
      ENSMUSP00000101955.2, ENSMUST00000106348.8
      Conserved Domains (1) summary
      pfam00274
      Location:15 → 364
      Glycolytic; Fructose-bisphosphate aldolase class-I

    3. NM_001411901.1 → NP_001398830.1  fructose-bisphosphate aldolase A isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC124505
      UniProtKB/TrEMBL
      A6ZI44

    4. NM_001411902.1 → NP_001398831.1  fructose-bisphosphate aldolase A isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC124505
      UniProtKB/TrEMBL
      A6ZI44

    5. NM_001411903.1 → NP_001398832.1  fructose-bisphosphate aldolase A isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      AC124505
      UniProtKB/TrEMBL
      A6ZI44

    6. NM_001411904.1 → NP_001398833.1  fructose-bisphosphate aldolase A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124505
      UniProtKB/Swiss-Prot
      P05064
      UniProtKB/TrEMBL
      Q5FWB7

    7. NM_007438.5 → NP_031464.1  fructose-bisphosphate aldolase A isoform 2

      See identical proteins and their annotated locations for NP_031464.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses a downstream start codon, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. Variants 2 and 3 encode the same protein.
      Source sequence(s)
      AC124505
      Consensus CDS
      CCDS21845.1
      UniProtKB/Swiss-Prot
      P05064
      UniProtKB/TrEMBL
      Q5FWB7, Q6NY00
      Related
      ENSMUSP00000032934.6, ENSMUST00000032934.12
      Conserved Domains (1) summary
      pfam00274
      Location:15 → 364
      Glycolytic; Fructose-bisphosphate aldolase class-I

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      126394406..126399537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05064.2 GenPept UniProtKB/Swiss-Prot:P05064

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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