Fxyd5 FXYD domain-containing ion transport regulator 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fxyd5provided by MGI
Official Full Name: FXYD domain-containing ion transport regulator 5provided by MGI
Primary source: MGI:MGI:1201785
See related: Ensembl:ENSMUSG00000009687 AllianceGenome:MGI:1201785
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RIC; EF-8; Oit2
Summary: This gene encodes a precursor protein that is member of the FXYD family of transmembrane glycoproteins. Like most members of the FXYD family, the encoded protein is a subunit of the sodium-potassium adenosine triphosphatase pump. FXYD family members have tissue-specific expression and differentially regulate the activity of this pump. The protein encoded by this gene also plays a role in cell adhesion and motility. The orthologous human protein inhibits epithelial cadherin, a calcium-dependent adhesion protein and is associated with cancer (promotes metastasis). Alternative splicing of this mouse gene results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Expression: Broad expression in thymus adult (RPKM 35.8), spleen adult (RPKM 33.6) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B1; 7 19.29 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (30732153..30741565, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (31032723..31042331, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The dysadherin/FAK axis promotes individual cell migration in colon cancer.
Title: The dysadherin/FAK axis promotes individual cell migration in colon cancer.
Dysadherin awakens mechanical forces and promotes colorectal cancer progression.
Title: Dysadherin awakens mechanical forces and promotes colorectal cancer progression.
FXYD5 mediates metastatic progression through regulation of the beta Na(+)-K(+)-ATPase subunit in the 4T1 mouse breast cancer model.
Title: FXYD5 (dysadherin) may mediate metastatic progression through regulation of the β-Na(+)-K(+)-ATPase subunit in the 4T1 mouse breast cancer model.
transfection of M1 epithelial cell line with FXYD5 largely increases lipopolysaccharide (LPS) stimulated CCL2 mRNA and secretion of the translated protein
Title: FXYD5 Protein Has a Pro-inflammatory Role in Epithelial Cells.
FXYD5 affects cell polarization through its interaction with Na(+)-K(+)-ATPase.
Title: Modulation of cell polarization by the Na+-K+-ATPase-associated protein FXYD5 (dysadherin).
Expressing FXYD5 in mouse kidney collecting duct cell line M1 led to a large decrease in amiloride-insensitive transepithelial electrical resistance as well as increased permeability to 4-kDa dextran.
Title: FXYD5 (dysadherin) regulates the paracellular permeability in cultured kidney collecting duct cells.
FXYD5 is significantly increased in the lungs and nasal epithelium of cystic fibrosis mice as assessed by RT-PCR.
Title: FXYD5 modulates Na+ absorption and is increased in cystic fibrosis airway epithelia.
data suggest that different FXYD proteins interact similarly with the Na(+)-K(+)-ATPase and their transmembrane domains
Title: Structural and functional interactions between FXYD5 and the Na+-K+-ATPase.
The role of FXYD5 in Na,K-ATPase activity, its cellular and tissue distribution, and its biochemical properties are reported.
Title: Interaction with the Na,K-ATPase and tissue distribution of FXYD5 (related to ion channel).

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation
Gene trapped (1)

General gene information

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Markers

AI849202 (e-PCR)
- UniSTS:179552

U72680 (e-PCR)
- UniSTS:159626

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables ion channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables potassium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium channel regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium channel regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables sodium channel regulator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of sodium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: FXYD domain-containing ion transport regulator 5

Names: dysadherin; ion channel homolog RIC; oncoprotein induced transcript 2; oncoprotein-induced protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111073.3 → NP_001104543.1 FXYD domain-containing ion transport regulator 5 isoform a precursor

See identical proteins and their annotated locations for NP_001104543.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC149055

Consensus CDS

CCDS21121.1

UniProtKB/Swiss-Prot

P97808, Q3TDW1

UniProtKB/TrEMBL

E0CXN1

Related

ENSMUSP00000125398.2, ENSMUST00000161805.8

Conserved Domains (1) summary

pfam02038
Location:130 → 167

ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family
NM_001287213.2 → NP_001274142.1 FXYD domain-containing ion transport regulator 5 isoform a precursor

See identical proteins and their annotated locations for NP_001274142.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC149055

Consensus CDS

CCDS21121.1

UniProtKB/Swiss-Prot

P97808, Q3TDW1

UniProtKB/TrEMBL

E0CXN1

Related

ENSMUSP00000125065.2, ENSMUST00000162087.8

Conserved Domains (1) summary

pfam02038
Location:130 → 167

ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family
NM_001287217.2 → NP_001274146.1 FXYD domain-containing ion transport regulator 5 isoform b precursor

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded protein (isoform b) is longer than isoform a. Variants 4 and 5 both encode the same isoform (b).

Source sequence(s)

AC149055

Consensus CDS

CCDS71935.1

UniProtKB/TrEMBL

E0CXN1, F8WJA1

Related

ENSMUSP00000009831.8, ENSMUST00000009831.14

Conserved Domains (2) summary

PRK14971
Location:7 → 132

PRK14971; DNA polymerase III subunit gamma/tau

cd20323
Location:129 → 176

FXYD_FXYD5; FXYD domain of FXYD domain-containing ion transport regulator 5
NM_001417006.1 → NP_001403935.1 FXYD domain-containing ion transport regulator 5 isoform b precursor

Status: VALIDATED

Source sequence(s)

AC149055

UniProtKB/TrEMBL

E0CXN1, F8WJA1
NM_001417007.1 → NP_001403936.1 FXYD domain-containing ion transport regulator 5 isoform c precursor

Status: VALIDATED

Source sequence(s)

AC149055

UniProtKB/TrEMBL

E0CXN1
NM_001417008.1 → NP_001403937.1 FXYD domain-containing ion transport regulator 5 isoform d precursor

Status: VALIDATED

Source sequence(s)

AC149055

UniProtKB/TrEMBL

E0CXN1
NM_001417009.1 → NP_001403938.1 FXYD domain-containing ion transport regulator 5 isoform e precursor

Status: VALIDATED

Source sequence(s)

AC149055

UniProtKB/TrEMBL

E0CXN1
NM_001417010.1 → NP_001403939.1 FXYD domain-containing ion transport regulator 5 isoform e precursor

Status: VALIDATED

Source sequence(s)

AC149055

UniProtKB/TrEMBL

E0CXN1
NM_008761.5 → NP_032787.1 FXYD domain-containing ion transport regulator 5 isoform a precursor

See identical proteins and their annotated locations for NP_032787.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.

Source sequence(s)

AC149055

Consensus CDS

CCDS21121.1

UniProtKB/Swiss-Prot

P97808, Q3TDW1

UniProtKB/TrEMBL

E0CXN1

Related

ENSMUSP00000125285.2, ENSMUST00000161684.8

Conserved Domains (1) summary

pfam02038
Location:130 → 167

ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family