Clec11a C-type lectin domain family 11, member a [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Clec11aprovided by MGI
Official Full Name: C-type lectin domain family 11, member aprovided by MGI
Primary source: MGI:MGI:1298219
See related: Ensembl:ENSMUSG00000004473 AllianceGenome:MGI:1298219
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Scgf; Clecsf3
Summary: Predicted to enable growth factor activity. Predicted to be involved in ossification and positive regulation of cell population proliferation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; head mesenchyme; renal vasculature; and retina nuclear layer. Orthologous to human CLEC11A (C-type lectin domain containing 11A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in ovary adult (RPKM 13.9), limb E14.5 (RPKM 11.9) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B3; 7 28.83 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (43953190..43956383, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (44303766..44306959, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The effect of parathyroid hormone on osteogenesis is mediated partly by osteolectin.
Title: The effect of parathyroid hormone on osteogenesis is mediated partly by osteolectin.
Recombinant human Clec11a (rClec11a) protein promoted the proliferation of islet cells.
Title: Protective effects of Clec11a in islets against lipotoxicity via modulation of proliferation and lipid metabolism in mice.
In situ hybridization of whole mouse fetuses and their tibias demonstrated expression of SCGF mRNA around skeletal tissues, particularly in bone marrow cells, proliferating chondrocytes, the perichondrium and periosteum.
Title: Stem cell growth factor: in situ hybridization analysis on the gene expression, molecular characterization and in vitro proliferative activity of a recombinant preparation on primitive hematopoietic progenitor cells.
This protein mediates eosinophil recruitment in a mouse model of allergic pleurisy via production of the chemoattractant lipid leukotriene B4.
Title: Stem cell factor-induced leukotriene B4 production cooperates with eotaxin to mediate the recruitment of eosinophils during allergic pleurisy in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation

General gene information

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Markers

AW457320 (e-PCR)
- UniSTS:179562

BF400111 (e-PCR)
- UniSTS:244848

BF398927 (e-PCR)
- UniSTS:247014

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	NAS Non-traceable Author Statement more info	PubMed
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ossification	IBA Inferred from Biological aspect of Ancestor more info
involved_in ossification	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular region	ISO Inferred from Sequence Orthology more info
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: C-type lectin domain family 11 member A

Names: lymphocyte secreted C-type lectin; osteolectin; stem cell growth factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.