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    Syngr4 synaptogyrin 4 [ Mus musculus (house mouse) ]

    Gene ID: 58867, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Syngr4provided by MGI
    Official Full Name
    synaptogyrin 4provided by MGI
    Primary source
    MGI:MGI:1928903
    See related
    Ensembl:ENSMUSG00000040231 AllianceGenome:MGI:1928903
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700016O14Rik
    Summary
    Predicted to be located in membrane. Predicted to be active in neuromuscular junction and synaptic vesicle membrane. Orthologous to human SYNGR4 (synaptogyrin 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward testis adult (RPKM 108.5) See more
    Orthologs
    human all
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    Genomic context

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    See Syngr4 in Genome Data Viewer
    Location:
    7 B3; 7 29.58 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45535502..45546152, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45886078..45896727, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene glutamate receptor, ionotropic, NMDA2D (epsilon 4) Neighboring gene predicted gene 45441 Neighboring gene KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 Neighboring gene STARR-positive B cell enhancer ABC_E1087 Neighboring gene transmembrane protein 143 Neighboring gene STARR-positive B cell enhancer ABC_E8172 Neighboring gene epithelial membrane protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models. Marques RF, et al. Hum Mol Genet, 2020 Sep 29. PMID 32686835, Free PMC Article
    2. Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. Miyata H, et al. Proc Natl Acad Sci U S A, 2016 Jul 12. PMID 27357688, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models.
      Title: Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in synaptic vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    synaptogyrin-4
    Names
    synaptogyrin 4 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291064.1 → NP_001277993.1  synaptogyrin-4 isoform 2

      See identical proteins and their annotated locations for NP_001277993.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate exon compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AA231032, AC149053, AK006050, BX635824
      Consensus CDS
      CCDS71968.1
      UniProtKB/TrEMBL
      D3Z3G3
      Related
      ENSMUSP00000113955.2, ENSMUST00000120299.4
      Conserved Domains (1) summary
      pfam01284
      Location:18 → 109
      MARVEL; Membrane-associating domain

    2. NM_021482.2 → NP_067457.2  synaptogyrin-4 isoform 1

      See identical proteins and their annotated locations for NP_067457.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AK006050, BC048469, BX635824
      Consensus CDS
      CCDS39962.1
      UniProtKB/Swiss-Prot
      Q80ZT0, Q9DA94, Q9Z1L2
      UniProtKB/TrEMBL
      A0A0R4J0K3
      Related
      ENSMUSP00000047035.8, ENSMUST00000039049.16
      Conserved Domains (1) summary
      pfam01284
      Location:18 → 163
      MARVEL; Membrane-associating domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45535502..45546152 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541034.3 → XP_006541097.1  synaptogyrin-4 isoform X1

      See identical proteins and their annotated locations for XP_006541097.1

      UniProtKB/Swiss-Prot
      Q80ZT0, Q9DA94, Q9Z1L2
      UniProtKB/TrEMBL
      A0A0R4J0K3
      Conserved Domains (1) summary
      pfam01284
      Location:18 → 163
      MARVEL; Membrane-associating domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1L2.2 GenPept UniProtKB/Swiss-Prot:Q9Z1L2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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