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    Zpbp zona pellucida binding protein [ Mus musculus (house mouse) ]

    Gene ID: 53604, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zpbpprovided by MGI
    Official Full Name
    zona pellucida binding proteinprovided by MGI
    Primary source
    MGI:MGI:1855701
    See related
    Ensembl:ENSMUSG00000020193 AllianceGenome:MGI:1855701
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Sp38; Iam38; 4930486K01Rik
    Summary
    Acts upstream of or within acrosome assembly and binding activity of sperm to zona pellucida. Located in acrosomal vesicle and cell body. Part of zona pellucida receptor complex. Human ortholog(s) of this gene implicated in spermatogenic failure 66. Orthologous to human ZPBP (zona pellucida binding protein). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 21.9) and CNS E11.5 (RPKM 0.5) See more
    Orthologs
    human all
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    Genomic context

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    See Zpbp in Genome Data Viewer
    Location:
    11 A1; 11 6.76 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (11229624..11414222, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (11279624..11464223, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28579 Neighboring gene STARR-seq mESC enhancer starr_28580 Neighboring gene 60S ribosomal protein L36 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28581 Neighboring gene STARR-seq mESC enhancer starr_28583 Neighboring gene STARR-seq mESC enhancer starr_28584 Neighboring gene STARR-seq mESC enhancer starr_28585 Neighboring gene STARR-seq mESC enhancer starr_28586 Neighboring gene STARR-seq mESC enhancer starr_28587 Neighboring gene STARR-seq mESC enhancer starr_28588 Neighboring gene STARR-seq mESC enhancer starr_28589 Neighboring gene STARR-seq mESC enhancer starr_28590 Neighboring gene STARR-seq mESC enhancer starr_28591 Neighboring gene STARR-seq mESC enhancer starr_28592 Neighboring gene STARR-seq mESC enhancer starr_28593 Neighboring gene von Willebrand factor C domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_28594 Neighboring gene predicted gene, 39578 Neighboring gene BRCA1/BRCA2-containing complex, subunit 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_28595 Neighboring gene STARR-positive B cell enhancer mm9_chr11:11361594-11361894 Neighboring gene STARR-positive B cell enhancer ABC_E10664 Neighboring gene STARR-positive B cell enhancer ABC_E8871 Neighboring gene predicted gene, 26458 Neighboring gene TGF beta-inducible nuclear protein 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:11428864-11429017 Neighboring gene STARR-positive B cell enhancer ABC_E2348 Neighboring gene sperm microtubule inner protein 7 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:11464295-11464600 Neighboring gene STARR-seq mESC enhancer starr_28596 Neighboring gene RIKEN cDNA 4930512M02 gene Neighboring gene STARR-seq mESC enhancer starr_28597 Neighboring gene predicted gene, 29945 Neighboring gene predicted gene 11998

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The origin and assembly of a zona pellucida binding protein, IAM38, during spermiogenesis. Yu Y, et al. Microsc Res Tech, 2009 Aug. PMID 19204925
    2. Molecular and immunological approaches to mammalian fertilization. Mori T, et al. J Reprod Immunol, 2000 Jul. PMID 10924747
    3. SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia. Fujihara Y, et al. Development, 2012 Oct. PMID 22949614
    4. Loss of zona pellucida binding proteins in the acrosomal matrix disrupts acrosome biogenesis and sperm morphogenesis. Lin YN, et al. Mol Cell Biol, 2007 Oct. PMID 17664285, Free PMC Article
    5. Differentially expressed genes in adipose tissues of high body weight-selected (obese) and unselected (lean) mouse lines. Aksu S, et al. J Appl Genet, 2007. PMID 17495347

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in acrosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within acrosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in binding of sperm to zona pellucida IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within binding of sperm to zona pellucida IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in acrosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in acrosomal vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in acrosomal vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in acrosomal vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of zona pellucida receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of zona pellucida receptor complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zona pellucida-binding protein 1
    Names
    inner acrosomal membrane IAM38

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001185153.1 → NP_001172082.1  zona pellucida-binding protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001172082.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AL662805, AL663071, BC145628
      UniProtKB/Swiss-Prot
      Q62522, Q9CR97
      UniProtKB/TrEMBL
      B7ZP49
      Conserved Domains (2) summary
      pfam07354
      Location:87 → 350
      Sp38; Zona-pellucida-binding protein (Sp38)
      smart00410
      Location:98 → 151
      IG_like; Immunoglobulin like

    2. NM_015785.2 → NP_056600.1  zona pellucida-binding protein 1 isoform 1

      See identical proteins and their annotated locations for NP_056600.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL662805, AL663071, BC139450
      Consensus CDS
      CCDS24434.1
      UniProtKB/Swiss-Prot
      Q62522, Q9CR97
      UniProtKB/TrEMBL
      Q5NC84
      Related
      ENSMUSP00000020413.4, ENSMUST00000020413.4
      Conserved Domains (2) summary
      pfam07354
      Location:144 → 407
      Sp38; Zona-pellucida-binding protein (Sp38)
      smart00410
      Location:155 → 208
      IG_like; Immunoglobulin like

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      11229624..11414222 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246152.2 → XP_030102012.1  zona pellucida-binding protein 1 isoform X2

      Conserved Domains (1) summary
      pfam07354
      Location:102 → 275
      Sp38; Zona-pellucida-binding protein (Sp38)

    2. XM_006514755.4 → XP_006514818.1  zona pellucida-binding protein 1 isoform X2

      Conserved Domains (1) summary
      pfam07354
      Location:102 → 275
      Sp38; Zona-pellucida-binding protein (Sp38)

    3. XM_011243736.4 → XP_011242038.1  zona pellucida-binding protein 1 isoform X1

      Conserved Domains (2) summary
      smart00409
      Location:155 → 208
      IG; Immunoglobulin
      pfam07354
      Location:234 → 292
      Sp38; Zona-pellucida-binding protein (Sp38)

    RNA

    1. XR_004936990.1 RNA Sequence

    2. XR_380974.5 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62522.2 GenPept UniProtKB/Swiss-Prot:Q62522

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