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    Pradc1 protease-associated domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 73327, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pradc1provided by MGI
    Official Full Name
    protease-associated domain containing 1provided by MGI
    Primary source
    MGI:MGI:1920577
    See related
    Ensembl:ENSMUSG00000030008 AllianceGenome:MGI:1920577
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pap21; 1700040I03Rik
    Summary
    Predicted to be located in extracellular region. Is expressed in submandibular gland primordium and thymus primordium. Orthologous to human PRADC1 (protease associated domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 8.3), thymus adult (RPKM 7.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pradc1 in Genome Data Viewer
    Location:
    6 C3; 6 37.46 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (85423767..85428969, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (85446785..85451987, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene notochord homeobox Neighboring gene SET and MYND domain containing 5 Neighboring gene chaperonin containing TCP1 subunit 7 Neighboring gene F-box protein 41 Neighboring gene early growth response 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PRADC1: a novel metabolic-responsive secretory protein that modulates physical activity and adiposity. Rodriguez S, et al. FASEB J, 2019 Dec. PMID 31689374, Free PMC Article
    2. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    3. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PRADC1-deficient mice have reduced adiposity and enhanced locomotor activity uncoupled from metabolic health.
      Title: PRADC1: a novel metabolic-responsive secretory protein that modulates physical activity and adiposity.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    protease-associated domain-containing protein 1
    Names
    protease-associated domain-containing protein of 21 kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163427.1 → NP_001156899.1  protease-associated domain-containing protein 1 isoform b precursor

      See identical proteins and their annotated locations for NP_001156899.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate in-frame exon in the 3' coding region, compared to variant 1. This results in a longer protein (isoform b) compared to isoform a.
      Source sequence(s)
      AC155728, AK006658, CJ208123
      Consensus CDS
      CCDS51828.1
      UniProtKB/Swiss-Prot
      Q9D9N8
      Related
      ENSMUSP00000032080.3, ENSMUST00000032080.9
      Conserved Domains (1) summary
      cd02127
      Location:51 → 168
      PA_hPAP21_like; Protease-associated domain containing proteins like the human secreted glycoprotein hPAP21 (human protease-associated domain-containing protein, 21kDa). This group contains various PA domain-containing proteins similar to hPAP21. Complex N-glycosylation ...

    2. NM_028505.2 → NP_082781.1  protease-associated domain-containing protein 1 isoform a precursor

      See identical proteins and their annotated locations for NP_082781.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shortest transcript and encodes the shorter isoform (a).
      Source sequence(s)
      AC155728, AK006658, CJ208123
      Consensus CDS
      CCDS39538.1
      UniProtKB/TrEMBL
      Q14C45
      Related
      ENSMUSP00000109400.2, ENSMUST00000113770.2
      Conserved Domains (1) summary
      cl28883
      Location:51 → 112
      PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...

    RNA

    1. NR_028081.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains two alternate exons compared to variant 1. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because there is uncertainty about the protein-coding capacity of the transcript.
      Source sequence(s)
      AC155728, AK006658, BG088874, CJ075544, CJ208123
      Related
      ENSMUST00000126805.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      85423767..85428969 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011241486.2 → XP_011239788.1  protease-associated domain-containing protein 1 isoform X1

      See identical proteins and their annotated locations for XP_011239788.1

      UniProtKB/Swiss-Prot
      Q9D9N8
      Conserved Domains (1) summary
      cd02127
      Location:51 → 168
      PA_hPAP21_like; Protease-associated domain containing proteins like the human secreted glycoprotein hPAP21 (human protease-associated domain-containing protein, 21kDa). This group contains various PA domain-containing proteins similar to hPAP21. Complex N-glycosylation ...

    RNA

    1. XR_003956256.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D9N8.1 GenPept UniProtKB/Swiss-Prot:Q9D9N8

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